Patents by Inventor Frank Sommerhage

Frank Sommerhage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Model and methods for identifying points of action in electrically active cells
    Patent number: 9489474
    Abstract: The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: November 8, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Hickman, Peter Molnar, Frank Sommerhage, Jonathan Ernest Hood, Jerry Jenkins
  • Model and Methods for Identifying Points of Action in Electrically Active Cells
    Publication number: 20130096888
    Abstract: The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
    Type: Application
    Filed: February 7, 2011
    Publication date: April 18, 2013
    Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: James Hickman, Peter Molnar, Frank Sommerhage, Jonathan Hood, Jerry Jenkins