Abstract: A system for heat-treating a coil of metal can include a furnace, an unwinding system, and a quenching system. The furnace may receive the coil of metal and elevate a temperature of the metal to be within a pre-heated temperature range, such as a homogenizing temperature range or an annealing temperature range. The unwinding system may unwind at least a portion of the coil in a heated state in which the metal is within the pre-heated temperature range or before the metal has cooled past a threshold amount below the pre-heated temperature range. The quenching system may receive the unwound portion of the coil from the unwinding device and reduce a temperature of the unwound portion to a within a quenched temperature range within a predetermined amount of time.

Abstract: A rapid quenching line can be suitable for use with hot coil at, or above the metal strip's recrystallization point. Hot coil can be uncoiled by a low tension uncoiler using a non-contacting hold-down device. The metal strip coming off the hot coil is rapidly quenched (e.g., at rates of at or above 100° C./s or 200° C./s) through multiple quenching zones. Coolant can be removed, such as with an air knife and/or a wiper (e.g., an ultra-compliant wiper). Steam can be collected from earlier quenching zones and be repurposed to provide humid air to the metal strip, such as at regions where the temperature of the metal strip is at or below the Leidenfrost point. The cooled metal strip can pass through a bridle to increase the tension in the metal strip before the metal strip is optionally lubricated and then recoiled or otherwise further processed.

Abstract: Provided herein are systems and methods for containing a viscous material, such as coolant, applied to cool a roll or a roll processed engineering material such as a metal strip. In particular, a viscous material containment system can include a housing, a viscous material delivery system, a plurality of movable seals and a plurality of gas delivery devices. A method for cooling a roll can include applying a vicious material, such as coolant, to the roll and containing the viscous material on the roll using the viscous material containment system. In some cases, the viscous material containment system can be used to facilitate removal of the viscous material from the roll.

Abstract: Provided herein are systems and methods for containing a viscous material, such as coolant, applied to cool a roll or a roll processed engineering material such as a metal strip. In particular, a viscous material containment system can include a housing, a viscous material delivery system, a plurality of movable seals and a plurality of gas delivery devices. A method for cooling a roll can include applying a vicious material, such as coolant, to the roll and containing the viscous material on the roll using the viscous material containment system. In some cases, the viscous material containment system can be used to facilitate removal of the viscous material from the roll.

Abstract: In embodiments of the invention, a tamper-evident bag includes multiple side walls, a closed bottom, and an opening defined by a top edge of the multiple side walls. A handle feature is disposed on two side walls. A pressure-sensitive adhesive strip is disposed proximate to the top edge of a first side wall. A perforation line of uniform height is disposed in the multiple side walls above the handle feature and below the pressure-sensitive adhesive strip. Methods for using and manufacturing a reusable tamper-evident bag are also disclosed.

Abstract: The present application relates to novel thieno[2,3-d]pyrimidine-2,4-dione (“thienouracil”) derivatives bearing a particular type of (azaheterocyclyl)methyl substituent, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of pulmonary and cardiovascular disorders and of cancer.

Abstract: In variations of embodiments, a tamper-evident bag includes multiple side walls, a closed bottom, and an opening defined by a top edge of the multiple side walls; a handle feature is disposed on two side walls; a pressure-sensitive adhesive strip is disposed proximate to the top edge of a first side wall; and/or a perforation line of uniform height is disposed in the multiple side walls above the handle feature and below the pressure-sensitive adhesive strip. In variations of embodiments, methods for using and manufacturing a reusable tamper-evident bag are also disclosed.

Abstract: A personnel management system and method is disclosed. The personnel management system comprises beacons distributed around an employer facility to assist in tracking employee movement, automating punch-in and punch-out events, automating timecard record keeping, and providing navigation services within the employer facility. Detection of an employee in proximity to a particular beacon triggers a server system to log the time of the detection and update of the employee's timecard with a punch-in event, if confirmed by the employee. Similarly, detection of the employee later triggers the server system to log the time of the detection and update of the employee's timecard with a punch-out event. In some embodiments, the beacons interact with employee mobile phones via a BLUETOOTH protocol. Automation of these operations improves the accuracy and convenience of employee timekeeping while preventing some types of fraudulent behavior, thereby saving employers money.

Abstract: The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.

Abstract: The present application relates to novel 2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives (“thienouracil”-carboxamides), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for the preparation of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiovascular disorders.

Abstract: The present application relates to novel 1-phenyl-1H-imidazo[1,2-b]pyrazole derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular angiogenic disorders and hyperproliferative disorders, where neovascularization plays a role, such as, for example, neoplastic disorders and tumor disorders. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.

Abstract: This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.

Abstract: The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present application relates to novel substituted 4-amino-3,5-dicyano-2-thiopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.

Abstract: The present application relates to novel substituted fused cyanopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present application relates to novel substituted pyrrolopyridine, pyrazolopyridine and isoxazolopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.

Abstract: The present application relates to novel heteroaryl-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.

Abstract: The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.