Abstract: A method produces a radioactively marked carboxylate, at least one precursor molecule of the carboxylate being prepared in a solvent including a conductive salt. Radioactively marked carbon dioxide is fed into the solvent. The precursor molecule is electrochemically reacted with the radioactively marked carbon dioxide to form the radioactively marked carboxylate. The radioactively marked carbon dioxide is completely dissolved in the solvent when the precursor molecule is reacted. The radioactively marked carbon dioxide is used for electrochemically synthesizing a radioactively marked carboxylate, the carbon dioxide being completely dissolved in a solvent during synthesis. A microstructure is used for electrochemically synthesizing the radioactively marked carboxylate, radioactively marked carbon dioxide being reacted.

Abstract: A method produces a radiopharmaceutical. In the method, an H—Li exchange is made by adding an alkyllithium to an isocyanide, wherein the ?-H atom of the isocyanide is replaced with an Li atom. 11CO2 is added and bonded to the ?-C atom of the isocyanide. By a two-stage hydrolysis, the Li atom is replaced with an H atom and an amino group is formed from the isocyanide group, for example, by adding NH4Cl and HI. The reaction is continuously performed in particular in a microfluidic structure so that reaction times of less than 300 seconds can be achieved for the partial steps. Because the produced radiopharmaceutical has only a low half-life, the short production time has a positive effect on the yield of radioactive pharmaceutical.