Patents by Inventor Frank U. Axe

Frank U. Axe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted benzimidazoles and imidazo-[4,5]-pyridines
    Patent number: 7687639
    Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: March 30, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael K. Ameriks, Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher
  • MONOCYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
    Publication number: 20090118274
    Abstract: Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
    Type: Application
    Filed: February 14, 2008
    Publication date: May 7, 2009
    Inventors: Darin Allen, Michael K. Ameriks, Frank U. Axe, Matthew Burdett, Hui Cai, Ingrid Choong, James P. Edwards, Willard Lew, Steven P. Meduna
  • Substituted benzimidazoles and imidazo-[4,5]-pyridines
    Patent number: 7504414
    Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: March 17, 2009
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher, Liming Huang, Alice Lee, Kelly J. McClure
  • BICYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
    Publication number: 20080269241
    Abstract: Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
    Type: Application
    Filed: February 14, 2008
    Publication date: October 30, 2008
    Inventors: Darin Allen, Michael K. Ameriks, Frank U. Axe, Matthew Burdett, Hui Cai, Ingrid Choong, James P. Edwards, Willard Lew, Steven P. Meduna
  • CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
    Publication number: 20080200454
    Abstract: Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
    Type: Application
    Filed: February 14, 2008
    Publication date: August 21, 2008
    Inventors: Michael K. Ameriks, Frank U. Axe, James P. Edwards, Cheryl A. Grice, Hui Cai, Elizabeth Ann Gleason, Steven P. Meduna, Kevin L. Tays, John J. M. Wiener, Alvah T. Wickboldt
  • Substituted benzimidazoles and imidazo-[4,5]-pyridines
    Patent number: 7271261
    Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: September 18, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher, Liming Huang, Alice Lee, Kelly J. McClure
  • Substituted benzimidazoles and imidazo-[4,5]-pyridines
    Patent number: 7132440
    Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: November 7, 2006
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Michael K. Ameriks, Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher
  • Substituted benzimidazoles and imidazo-[4,5]-pyridines
    Publication number: 20040214857
    Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
    Type: Application
    Filed: April 16, 2004
    Publication date: October 28, 2004
    Inventors: Michael K. Ameriks, Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher
  • Substituted benzimidazoles and imidazo-[4,5]-pyridines
    Publication number: 20030176438
    Abstract: 2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
    Type: Application
    Filed: October 18, 2002
    Publication date: September 18, 2003
    Inventors: Kristen L. Arienti, Frank U. Axe, J. Guy Breitenbucher, Liming Huang, Alice Lee, Kelly J. McClure