Patents by Inventor Frank Villani

Frank Villani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRALIN AND SUBSTITUTED INDANE DERIVATIVES
    Publication number: 20090326258
    Abstract: The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.
    Type: Application
    Filed: July 13, 2009
    Publication date: December 31, 2009
    Inventors: Fan Zhan-Plasket, Hua Zhong, Frank Villani
  • Process for the preparation of benzotriazepine derivatives
    Patent number: 7582753
    Abstract: The present invention is directed to a novel process for the preparation of benzo[e][1,2,4]triazepin-2-one derivatives, useful in the preparation of gastrin and cholecystokinin receptor ligands.
    Type: Grant
    Filed: September 14, 2006
    Date of Patent: September 1, 2009
    Assignee: JanssenPharmaceutica, NV
    Inventors: Ahmed F. Abdel-Magid, Luigi Anzalone, Judith Cohen, Steven Mehrman, Frank Villani
  • Process for the preparation of substituted tetralin and substituted indane derivatives
    Patent number: 7576238
    Abstract: The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: August 18, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Fan Zhang-Plasket, Hua Zhong, Frank Villani
  • Salt forms of substituted benzothienyl compounds
    Publication number: 20080097110
    Abstract: The present invention relates to novel salt forms of a compound of Formula (I): and processes for their preparation.
    Type: Application
    Filed: October 19, 2007
    Publication date: April 24, 2008
    Inventors: Luigi Anzalone, Frank Villani, Penina Feibush
  • Process for the Preparation of Substituted Tetralin and Substituted Indane Derivatives
    Publication number: 20080096962
    Abstract: The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.
    Type: Application
    Filed: December 18, 2007
    Publication date: April 24, 2008
    Inventors: Fan Zhang-Plasket, Hua Zhong, Frank Villani
  • Process for preparing peptidyl heterocyclic ketone derivatives
    Patent number: 7205384
    Abstract: The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I) wherein all variables are as herein defined. The present invention further relates to novel pharmaceutical salts and processes for their preparation. The peptidyl heterocyclic ketones of formula (I) are potent and selective inhibitors of tryptase, useful for the treatment and prevention of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: April 17, 2007
    Assignee: Ortho-McNeil Pharmaceutical Inc.
    Inventors: Michael Breslav, Bruce Harris, Birdella Kenney, Thomas Maier, Armin Roessler, Frank Villani, Ulrich Weigl, Fan Zhang-Plasket, Hua Zhong
  • PROCESS FOR THE PREPARATION OF BENZOTRIAZEPINE DERIVATIVES
    Publication number: 20070066819
    Abstract: The present invention is directed to a novel process for the preparation of benzo[e][1,2,4]triazepin-2-one derivatives, useful in the preparation of gastrin and cholecystokinin receptor ligands.
    Type: Application
    Filed: September 14, 2006
    Publication date: March 22, 2007
    Inventors: Ahmed Abdel-Magid, Luigi Anzalone, Judith Cohen, Steven Mehrman, Frank Villani
  • Substituted sulfamate anticonvulsant derivatives
    Patent number: 7060725
    Abstract: The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy. The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: June 13, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff, Steven Mehrman, Kirk Sorgi, Frank Villani, Cheryl Kordik, Allen B. Reitz, Bruce Maryanoff
  • Liquid phase peptide synthesis of KL-4 pulmonary surfactant
    Publication number: 20060014929
    Abstract: The invention realtes to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the ?-carbon.
    Type: Application
    Filed: May 29, 2002
    Publication date: January 19, 2006
    Inventors: Ahmed Abdel-Magid, Urs Eggmann, Cynthia Maryanoff, Adrian Thaler, Frank Villani
  • Process for the preparation of substituted tetralin and substituted indane derivatives
    Publication number: 20050240049
    Abstract: The present invention relates to novel processes for the preparation of substituted tetralin. and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.
    Type: Application
    Filed: April 20, 2005
    Publication date: October 27, 2005
    Inventors: Fan Zhang-Plasket, Hua Zhong, Frank Villani
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Patent number: 6890921
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the ?-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: May 10, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Allen Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani
  • Process for preparing peptidyl heterocyclic ketone derivatives
    Publication number: 20050059607
    Abstract: The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I) wherein all variables are as herein defined. The present invention further relates to novel pharmaceutical salts and processes for their preparation. The peptidyl heterocyclic ketones of formula (I) are potent and selective inhibitors of tryptase, useful for the treatment and prevention of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.
    Type: Application
    Filed: July 29, 2004
    Publication date: March 17, 2005
    Inventors: Michael Breslav, Bruce Harris, Birdella Kenney, Thomas Maier, Armin Roessler, Frank Villani, Ulrich Weigl, Fan Zhang-Plasket, Hua Zhong
  • Heterocycles useful in the treatment of benign prostatic hyperplasia
    Patent number: 6841682
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the ?-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: January 11, 2005
    Assignee: Janseen Pharmaceutica N.V.
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C. F. Yim, Cynthia Maryanoff
  • Novel substituted sulfamate anticonvulsant derivatives
    Publication number: 20040038911
    Abstract: The present invention is directed to novel compounds of the formula (I) 1
    Type: Application
    Filed: May 8, 2003
    Publication date: February 26, 2004
    Inventors: Ahmed Abdel-Magid, Cynthia Maryanoff, Steven Mehrman, Kirk Sorgi, Frank Villani, Cheryl Kordik, Allen B. Reitz, Bruce Maryanoff
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Publication number: 20030220493
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I 1
    Type: Application
    Filed: June 2, 2003
    Publication date: November 27, 2003
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Allen Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Patent number: 6593474
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: July 15, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Linda Mulcahy, Xiaobing Li, Allen Reitz, Cynthia Maryanoff, Frank Villani
  • Novel heterocycles useful in the treatment of benign prostatic hyperplasia
    Publication number: 20020165219
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I 1
    Type: Application
    Filed: November 26, 2001
    Publication date: November 7, 2002
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C.F. Yim, Cynthia Maryanoff
  • Heterocycles useful in the treatment of benign prostatic hyperplasia
    Patent number: 6384035
    Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: May 7, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C. F. Yim, Cynthia Maryanoff
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Patent number: 6303594
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: October 16, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Allan Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani
  • Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
    Patent number: 6071915
    Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: June 6, 2000
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Linda Jolliffe, William Murray, Virginia Pulito, Allen Reitz, Xiaobing Li, Linda Mulcahy, Cynthia Maryanoff, Frank Villani