Abstract: A cover for a knob or handle is disclosed herein that carries a disinfectant in its porous material adapted to be slidably engaged over the knob or handle in order to substantially act as a barrier between the fingers of a person and the possible contaminated surface of the knob or handle. The cover includes a cup-like portion defining a pocket for insertably receiving the knob or handle in close frictional engagement. A neck portion extends or projects from the pocket to cover the mounting shaft of the knob or handle, and, if desired, a band retainer may be employed for holding the cover in place. A plurality of slits or openings are provided through the material, permitting the user's fingers to grab limited surface areas of the knob or handle allowing knob turning.