Abstract: A shifting arrangement for a dual clutch transmission as a change-speed transmission for motor vehicles, with two coaxially arranged input shafts, each of which can be activated via a respective clutch, an axially parallel output shaft and gear sets arranged on the shafts and shiftable by means of synchronous clutches to form a plurality of forward gears and one reverse gear, wherein the gear sets are subdivided into a first subtransmission with one of the input shafts and a second subtransmission with the other input shaft. A pre-shifting unit and/or post-shifting unit shiftable into at least two transmission ratio stages is associated with the first subtransmission and/or the second subtransmission.

Abstract: A sensor device (100), which is adapted for detecting target molecules having a target nucleic acid sequence, comprises an optical whispering gallery mode (WGM) resonator (10) having a resonance frequency, wherein the WGM resonator is functionalized with a double-strand DNA precursor compound and the 10 resonance frequency depends on a mass load provided by the double-strand precursor compound, the double-strand precursor compound is capable of a target-specific strand displacement reaction with the target molecules, and in response to the strand displacement reaction, the double-strand precursor 15 compound is capable to be partially decoupled from the WGM resonator (10), wherein the mass load can be decreased and the resonance frequency of the WGM resonator can be increased. Furthermore, a sensing method for detecting target molecules including nucleic acid sequences is described.

Abstract: Periodic high-index-contrast photonic crystal (PhC) structures such as two-dimensional arrays of air holes in dielectric slabs inhibit light propagation in bands of frequencies and confine light in dislocations where the lattice periodicity is broken. The present invention is a conceptually different approach to photon localization in PhC structures. The disclosed design concept introduces structural perturbations uniformly throughout the fabricated crystal by deliberately changing the shape or orientations of elements that form the lattice. Optimized introduction of such random structural perturbations produces optical nanocavities with ultra-small modal volumes and high quality (Q) factors of over 250,000. Applications of such disordered photonic crystal structures are disclosed for optical sensing systems and random nano-lasers.

Abstract: A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or electro-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid.

Abstract: A miniature optical biosensor and biosensor array where high sensitivity for detection of biomolecular interaction does not require a fluorescent label. Non-linear frequency-shifts of optical resonators (‘nanobeams’) provide a digital all-or-nothing response to equilibrium binding of a biomarker to surface-immobilized bio-recognition elements, a signal suitable to identify active components in genetic and proteomic circuits, as well as toxic substances. The threshold level for the digital response is adjustable to accommodate for varying receptor affinities. A bistable cavity sensing (BCS) method can be used to track the shift of the resonance induced by the analyte more precisely than the conventional cavity sensing method, where the resolution is limited by the cavity linewidth. BCS method can be used to quantitate the concentration of the analyte, and their binding kinetics, affinities and etc.

Abstract: The use of optical microcavities, high-Q resonators and slow-light structures as tools for detecting molecules and probing conformations and measuring polarizability and anisotropy of molecules and molecular assemblies using a pump-probe approach is described. Resonances are excited simultaneously or sequentially with pump and probe beams coupled to the same microcavity, so that a pump beam wavelength can be chosen to interact with molecules adsorbed to the microcavity surface, whereas a probe beam wavelength can be chosen to non-invasively measure pump-induced perturbations. The induced perturbations are manifest due to changes of resonance conditions and measured from changes in transfer characteristics or from changes of the scattering spectra of a microcavity-waveguide system. The perturbations induced by the pump beam may be due to polarizability changes, changes in molecular conformation, breakage or formation of chemical bonds, triggering of excited states, and formation of new chemical species.

Abstract: A clutch system has a clutch device, an actuating device for the hydraulic actuation of the clutch device, and a hydraulic system. The hydraulic system includes a master cylinder that is actuated by the actuating device, a slave cylinder for actuating the clutch device fluidically connected with the master cylinder through a pressure line. A first branch line is connected to the pressure space of the master cylinder or between the pressure spaces of the master cylinder and slave cylinder. The first branch line is also connected to a compensating tank volume. A second branch line is connected to the pressure space of the slave cylinder or arranged between the pressure spaces of the master and slave cylinders. The second branch line is also connected to the compensating tank volume. A device is disposed to blocking the second branch line during an actuation of the clutch device by way of the actuating device. This provides for an inherently safe, self-ventilating hydraulic system.

Abstract: An optical device that comprises an input waveguide, an output waveguide, a high-Q resonant or photonic structure that generate slow light connected to the input waveguide and the output waveguide, and an interface, surface or mode volume modified with at least one material formed from a single molecule, an ordered aggregate of molecules or nanostructures. The optical device may include more than one input waveguide, output waveguide, high-Q resonant or photonic structure and interface, surface or mode volume. The high-Q resonant or photonic structure may comprise at least one selected from the group of: microspherical cavities, microtoroidal cavities, microring-cavities, photonic crystal defect cavities, fabry-perot cavities, photonic crystal waveguides.

Abstract: Periodic high-index-contrast photonic crystal (PhC) structures such as two-dimensional arrays of air holes in dielectric slabs inhibit light propagation in bands of frequencies and confine light in dislocations where the lattice periodicity is broken. The present invention is a conceptually different approach to photon localization in PhC structures. The disclosed design concept introduces structural perturbations uniformly throughout the fabricated crystal by deliberately changing the shape or orientations of elements that form the lattice. Optimized introduction of such random structural perturbations produces optical nanocavities with ultra-small modal volumes and high quality (Q) factors of over 250,000. Applications of such disordered photonic crystal structures are disclosed for optical sensing systems and random nano-lasers.

Abstract: The use of optical microcavities, high-Q resonators and slow-light structures as tools for detecting molecules and probing conformations and measuring polarizability and anisotropy of molecules and molecular assemblies using a pump-probe approach is described. Resonances are excited simultaneously or sequentially with pump and probe beams coupled to the same microcavity, so that a pump beam wavelength can be chosen to interact with molecules adsorbed to the microcavity surface, whereas a probe beam wavelength can be chosen to non-invasively measure pump-induced perturbations. The induced perturbations are manifest due to changes of resonance conditions and measured from changes in transfer characteristics or from changes of the scattering spectra of a microcavity-waveguide system. The perturbations induced by the pump beam may be due to polarizability changes, changes in molecular conformation, breakage or formation of chemical bonds, triggering of excited states, and formation of new chemical species.

Abstract: An optical device that comprises an input waveguide, an output waveguide, a high-Q resonant or photonic structure that generate slow light connected to the input waveguide and the output waveguide, and an interface, surface or mode volume modified with at least one material formed from a single molecule, an ordered aggregate of molecules or nanostructures. The optical device may include more than one input waveguide, output waveguide, high-Q resonant or photonic structure and interface, surface or mode volume. The high-Q resonant or photonic structure may comprise at least one selected from the group of: microspherical cavities, microtoroidal cavities, microring-cavities, photonic crystal defect cavities, fabry-perot cavities, photonic crystal waveguides.

Abstract: A spectroscopic technique for high-sensitivity, label free DNA quantification uses a shift in an optical resonance (whispering gallery mode, WGM) excited in a micron-sized optical cavity (e.g., a silica sphere) to detect and measure nucleic acids. The surface of the silica sphere is chemically modified with oligonucleotides. Hybridization to the target DNA leads to a red-shift of the optical resonance wavelength. The sensitivity of this resonance technique is higher than most optical single-pass devices such as surface plasmon resonance biosensors. Each microsphere can be identified by its unique resonance wavelength. Specific, multiplexed DNA detection may be provided by using two or more microspheres. The multiplexed signal from two or more microspheres illustrates that a single nucleotide mismatch in an 11-mer oligonucleotide can be discriminated with a high signal-to-noise of 54.

Abstract: A clutch system has a clutch device, an actuating device for the hydraulic actuation of the clutch device, and a hydraulic system. The hydraulic system includes a master cylinder that is actuated by the actuating device, a slave cylinder for actuating the clutch device fluidically connected with the master cylinder through a pressure line. A first branch line is connected to the pressure space of the master cylinder or between the pressure spaces of the master cylinder and slave cylinder. The first branch line is also connected to a compensating tank volume. A second branch line is connected to the pressure space of the slave cylinder or arranged between the pressure spaces of the master and slave cylinders. The second branch line is also connected to the compensating tank volume. A device is disposed to blocking the second branch line during an actuation of the clutch device by way of the actuating device. This provides for an inherently safe, self-ventilating hydraulic system.

Abstract: A method and apparatus for performing refractive index, birefringence and optical activity measurements of a material such as a solid, liquid, gas or thin film. The apparatus has an optical ring-resonator with a closed optical path that constitutes a cavity. A sample is introduced into the optical path of the resonator such that the light in the resonator is transmitted through the sample and relative and/or absolute shifts of the resonance frequencies or changes of the characteristics of the transmission spectrum are observed. A change in the transfer characteristics of the resonant ring, such as a shift of the resonance frequency, is related to a sample's refractive index (refractive indices) and/or change thereof. A reflecting surface may be introduced in a ring resonator. The reflecting surface can be raster-scanned for the purpose of height-profiling surface features.

Abstract: A method and apparatus for performing refractive index, birefringence and optical activity measurements of a material such as a solid, liquid, gas or thin film is disclosed. The method and apparatus can also be used to measure the properties of a reflecting surface. The disclosed apparatus has an optical ring-resonator in the form of a fiber-loop resonator, or a race-track resonator, or any waveguide-ring or other structure with a closed optical path that constitutes a cavity. A sample is introduced into the optical path of the resonator such that the light in the resonator is transmitted through the sample and relative and/or absolute shifts of the resonance frequencies or changes of the characteristics of the transmission spectrum are observed. A change in the transfer characteristics of the resonant ring, such as a shift of the resonance frequency, is related to a sample's refractive index (refractive indices) and/or change thereof.

Abstract: A first-order perturbation theory similar to the one widely used in quantum mechanics is developed for transverse-electric and transverse-magnetic photonic resonance modes in a dielectric microsphere. General formulas for the resonance frequency shifts in response to a small change in the exterior refractive index and its radial profile are derived. The formulas are applied to two sensor applications of the microsphere to probe the medium in which the sphere is immersed: a refractive index detector; and a refractive index profile sensor.

Abstract: Detecting and/or measuring a chemical substance, such as explosives or poison gases, using a change in a property of light passing through a microsphere of a sensor. Since the microsphere has a large quality factor, the sensor is extremely sensitive. The sensor includes the microsphere coupled with at least one optical fiber. The surface of the microsphere includes receptors complementary to the chemical substance.

Abstract: Microsphere sensors (i) having receptors selectively substantially provided at only an equator region, (ii) formed of a relative high IR material, and/or (iii) having a relatively small radius are provided with improved sensitivity. Such a microsphere sensor may be made by selectively treating an equator region of the microsphere forming a small concentrated receptor band on the high sensitivity portion of the microsphere surface. Changing the selected laser frequency applied to the microsphere sensor to a shorter wavelength also improves sensitivity. Physical properties of the microsphere sensor system: index of refraction, laser frequency, and microsphere radius may be adjusted in concert to match the target entity molecule size. These improvements in sensitivity may allow detection and/or identification of unknown target entities based on detectable step shifts observable in light modes due to the adsorption of even a single molecule as small as about 200,000 Da.