Abstract: Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.

Abstract: The present invention relates to novel block copolymers of general formula (I). The invention further relates to a method for producing such block copolymers and to the use of such block copolymers, particularly as additives in liquid coating-agent compositions. A{X—[O—C(O)NH—Y—NH—C(O)—O-M-B]k}n (I).

Abstract: A location of a target associated with a first system is determined at the first system at a first time. A signal is constructed at the first system where the data of the signal includes an identifier indicative of a collision avoidance nature of the signal. The signal is broadcast from the first system. the broadcasting causes a second system to receive the signal; compute a likelihood of a collision between the first system and the second system using the location from the signal, a velocity of the first system, a location of the second system at the first time, and a velocity of the second system at the first time; and send a notification from the second system about the likelihood of collision when the likelihood of collision exceeding a threshold likelihood.

Abstract: Disclosed is a compound of Formula (I) or a pharmaceutically acceptable salt, ester, or solvate thereof, or their stereoisomers, which can be used as tyrosine kinase inhibitor. Also disclosed is a method for preparing the compound, a pharmaceutical composition and a kit comprising the compound, and uses of the compound. The compound can be used as tyrosine kinase inhibitor, or can be used to reduce or inhibit activity of EGFR or mutant thereof, such as EGFR mutant comprising T790M mutation, in a cell, or to treat and/or prevent a disease associated with overactivity of EGFR, such as cancer.

Abstract: The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.

Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

Abstract: A suspension system for the attachment of a multiple embodiments, including flat screen televisions and other embodiments connected beneath the roof of a canopy-styled tent or other overhead structure. The system's bracket is comprised of a single or multiple arms that universally grip the frame of the said canopy-styled tent or overhead structure. Suspension is not limited to a television, but also other embodiments, either powered by a plug or battery, or not powered. The bracket is manufactured in steel, aluminum, polymer, or like material. The system's fan blades are comprised of foam, rubber, or other soft matter. The suspension system allows the television's or other attached embodiment's height to be manipulated by a process further shown in this application.

Abstract: A complexly formed steel component may have a tensile strength Rm of greater than 1200 MPa and an elongation at break A50 of greater than 6%. Example methods for producing such components comprise providing a flat steel product, which in addition to iron and unavoidable impurities, contains in percent by weight 0.10-0.60% C, 0.4-2.5% Si, up to 3.0% Al, 0.4-3.0% Mn, up to 1% Ni, up to 2.0% Cu, up to 0.4% Mo, up to 2% Cr, up to 1.5% Co, up to 0.2% Ti, up to 0.2% Nb, and up to 0.5% V. At least 10% by volume of a microstructure of the flat steel product may consist of residual austenite comprising globular residual austenite islands with a grain size of at least 1 ?m. Before being cooled, the flat steel product may be heated to a forming temperature of 150-400° C. and formed into a component with a degree of forming that is at most equal to uniform elongation Ag.

Abstract: Managing storage volumes in a point-in-time copy cascade. The cascade includes a first source volume, a first target volume and a second target volume. The method detects a corruption of the first source volume and, if a first restoration of the first source volume from the first target volume is in progress, creates a third target volume from the second target volume and directs I/O operations for the first source volume to the third target volume. The first source volume is then restored from the third target volume.

Abstract: Techniques are described for controlling data and resource access. For example, methods and systems can facilitate controlled token distribution across systems and token processing in a manner so as to limit access to and to protect data that includes access codes.

Abstract: A cosmetology tool storage assembly for storing and supplying electrical power for a plurality of cosmetology tools includes a gate that is pivotally coupled to a vertical support surface in a salon or the like. Thus, the gate is accessible to a cosmetologist working in the salon. A power strip is coupled to the gate and the power strip has a plurality of female electrical outlets positioned thereon. A plurality of hooks is included and each of the hooks is coupled to the gate. Each of the hooks engages and thusly suspends a respective one of a plurality of cosmetology tools for storage and each of the cosmetology tools can be plugged into a respective female electrical outlet.

Abstract: A method for evaluating a transmission device using various characteristic values, wherein said characteristic values can be determined by means of variable or constant parameters.

Abstract: A method is disclosed for establishing and operating a wireless network with a first communication unit, a second communication unit and a mobile communication unit. The first and second communication units are configured in each case as a server and the mobile communication unit is configured as a client. The mobile communication unit acquires connection set-up data of the first and second communication units. A wireless connection is established from the mobile communication unit to the first communication unit. The latter receives an instruction from the mobile communication unit via the wireless connection for configuration as a client of the second communication unit and the mobile communication unit transfers the connection set-up data of the second communication unit to the first communication unit. A wireless connection is then established from the mobile communication unit to the second communication unit.

Abstract: An adhesive tape (1), in particular a double-sided adhesive tape has a substrate made of plastic with a self-adhesive, pressure-sensitive layer (3) consisting of a pressure-sensitive adhesive containing a UV-crosslinkable acrylate as primary constituent. In order to achieve an at least moderate, preferably increased adhesive force on nonpolar surfaces (4a) as well as preferably an increased shear strength, while preserving the advantages of the use of UV-crosslinkable acrylates in the adhesive coating and ensuring an at least moderate, preferably increased adhesive force on steel, the pressure-sensitive adhesive contains powdered silicon dioxide, wherein the substrate (2) made of plastic is configured as a film.

Abstract: The invention provides a chain-extended polydiorganosiloxane vinylic crosslinker which comprises (1) a polymer chain comprising at least two polydiorganosiloxane segments and one hydrophilized linker between each pair of polydiorganosiloxane segements, wherein each polydiorganosiloxane comprises at least 5 dimethylsiloxane units in a consecutive sequence, wherein the hydrophilized linker is a divalent radical having at least two (meth)acrylamide moieties; (2) two terminal (meth)acryloyl groups, wherein the chain-extended polydiorganosiloxane vinylic crosslinker has an average molecular weight of at least about 1500 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a chain-extended polydiorganosiloxane vinylic crosslinker of the invention.

Abstract: Compositions comprising wood veneer coated by a substrate contacting layer, a middle layer, and a top layer, methods of making such compositions and articles comprising such compositions.

Abstract: Active ingredient capsules are proposed which are obtainable by, with the input of mechanical and thermal energy, (a) dissolving and/or dispersing proteins, polysaccharides and cellulose derivatives in water, (b) adding the active ingredients to be encapsulated, (c) hardening the resulting coacervates with the addition of tannins and optionally (d) then subjecting them to a spray drying.

Abstract: Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems.

Abstract: A filter insert for a filter device, having a filter element arranged on a longitudinal axis extending there through and a front-side flow opening arranged on the front side of the filter element with the longitudinal axis extending through the flow opening. The filter element has, with respect to the longitudinal axis, at least one flattened portion with a reduced radial extension or a through hole along the periphery of the flow opening the shortest interior distance in the filter element immediately adjacent to the front-side flow opening is shorter than the inside diameter of the front-side flow opening.

Abstract: An axle carrier for a motor vehicle is disclosed having at least two attachment points, a metallic upper shell and a lower shell of fiber composite material coupled to the metallic upper shell. A first load path extending through the metallic upper shell between the at least two attachment points in an edge region, and a second load path shorter that the first load path extending through the lower shell.