Abstract: The invention relates to a drug delivery device comprising: a syringe with a body from which a needle extends and an inner sheath; a piston rod comprising a piston and an actuation head, a support sheath for holding the body. It is envisaged that the support sheath and the actuation head comprise corresponding indicators.

Abstract: A method for the joining of ceramic pieces with a hermetically sealed joint comprising brazing a layer of joining material between the two pieces. The wetting and flow of the joining material is controlled by the selection of the joining material, the joining temperature, the joining atmosphere, and other factors. The ceramic pieces may be on a non-diffusable type, such as aluminum nitride, alumina, beryllium oxide, and zirconia, and the pieces may be brazed with an aluminum alloy under controlled atmosphere. The joint material is adapted to later withstand both the environments within a process chamber during substrate processing, and the oxygenated atmosphere which may be seen within the shaft of a heater or electrostatic chuck.

Abstract: The present invention provides, among other things, methods of treating Argininosuccinate Synthetase Deficiency (ASD), including administering to a subject in need of treatment a composition comprising an mRNA encoding argininosuccinate synthetase (ASS1) at an effective dose and an administration interval such that at least one symptom or feature of ASD is reduced in intensity, severity, or frequency or has delayed in onset.

Abstract: An electronic device with one or more processors, memory and a display obtains information about a first and second sequence of media items. The device plays an initially-displayed media item of the first sequence and while playing the initially-displayed media item in a respective region of the display, detects a media-change input. In response to the input, when the media-change input corresponds to movement in a first direction, the device ceases to play the initially-displayed media item in the respective region and plays a first media item that is adjacent to the initially-displayed media item in the first sequence. When the media-change input corresponds to movement in a second, different, direction, the device ceases to play the initially-displayed media item in the respective region of the display and plays a second media item in the respective region, where the second media item is from the second sequence of media items.

Abstract: The present invention relates to substituted quinazolines of formula (I) wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: A magnetic resonance (MR) system (10) generates an attenuation or density map. The system (10) includes a MR scanner (48) defining an examination volume (16) and at least one processor (54). The at least one processor (54) is programmed to control the MR scanner (48) to apply imaging sequences to the examination volume (16). In response to the imaging sequences, MR data sets of the examination volume (16) are received and analyzed to identify different tissue and/or material types found in pixels or voxels of the attenuation or density map. One or more tissue-specific and/or material-specific attenuation or density values are assigned to each pixel or voxel of the attenuation or density map based on the tissue and/or material type(s) identified as being in each pixel or voxel during the analysis of the MR data sets. In one embodiment, the tissue and/or material types are identified on the basis of a time series of MR phase images.

Abstract: The invention relates to a device for setting at least one operating parameter of ink for a printing process of a rotary printing press, comprising an inking system which has a doctor blade device with a doctor blade chamber containing the ink for the printing process, and an ink reservoir from which ink can be supplied to the doctor blade chamber, and further comprising a supply system which allows ink to be supplied inside the inking system. According to the invention, the supply system is designed such that the supply system can be switched to a setting mode or to a production mode, the operating parameter being automatically set in the setting mode and no ink being supplied to the doctor blade chamber, and the supply system supplying ink to the doctor blade chamber in the production mode.

Abstract: Exemplary systems for processing a corpus of documents, such as legal contracts or agreements, are disclosed. The systems include a phrase discovery engine which derives statistics and phrase equivalence classes, groups of phrase equivalence classes, and uberphrases (clauses) bounded by phrases. These can be used to determine origins of phrases or clauses within given legal contract or to suggest alternative phrases and clauses.

Abstract: A sub-frame assembly for attachment to a unibody of a vehicle and for supporting at least one vehicular component is provided. The sub-frame assembly includes a pair of longitudinal members which are spaced from one another in a lateral direction and extend in a longitudinal direction between first and second ends. The longitudinal members at least partially converge towards one another from the first ends to the second ends such that the second ends are closer to one another than the first ends. A cross-member is coupled with and extends laterally between the longitudinal members. Each of the longitudinal members and the cross-member has a single and no more than one body mount for connection with the unibody of the vehicle such that the sub-frame assembly has exactly three body mounts in total.

Abstract: An ion beam scanner includes a first scanner stage having a first opening to transmit an ion beam, the first scanner stage to generate, responsive to a first oscillating deflection signal, a first oscillating deflecting field within the first opening; a second scanner stage disposed downstream of the first scanner stage and having a second opening to transmit the ion beam, the second scanner stage to generate, responsive to a second oscillating deflection signal, a second oscillating deflecting field within the second opening that is opposite in direction to the first oscillating deflecting field, and a scan controller to synchronize the first oscillating deflection signal and second oscillating deflection signal to generate a plurality of ion trajectories when the scanned ion beam exits the second stage that define a common focal point.

Abstract: Weakly consolidated formations, semi consolidated formations, or unconsolidated formations treated with an aggregating, agglomerating or conglomerating composition, which alters an aggregation or zeta potential of formation surfaces and particulate to increase a maximum sand free production rate of producing formations and increases the injection rate of injection formations.

Abstract: Manufacturing of semiconductor devices often involves performed photolithography to pattern and etch the various features of those devices. Such photolithography involves masking and focusing light onto a surface of the semiconductor device for exposing and etching the features of the semiconductor devices. However, due to design specifications and other causes, the semiconductor devices may not have a perfectly flat light-incident surface. Rather, some areas of the semiconductor device may be raised or lowered relative to other areas of the semiconductor device. Therefore, focusing the light on one area causes another to become unfocused. By carefully designing a photomask to cause phase shifts of the light transmitted therethrough, focus across all areas of the semiconductor device can be achieved during photolithography, which results in sharp and accurate patterns formed on the semiconductor device.

Abstract: A method of co-ordinating communication between a plurality of base stations in a communication system, comprising designating timeslots where said base stations receive and/or transit co-ordination messages to each other. The system may be an autonomous cellular system and the timeslots may be regularly spaced.

Abstract: The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: A market based interleaved wagering system is disclosed. The system includes an interactive controller constructed to: provide an interactive application; receive an identification of one or more application generated stocks; communicate the stock identification and application telemetry; and receive a wager outcome and an application resource based on the identified stocks and application telemetry. The system also includes a wager controller constructed to: receive a wager request and the stock identification; communicate a request for stock information associated with the stock identification; receive stock information associated with the stock identification; generate a wager outcome based on the stock information; and communicate the wager outcome.

Abstract: The present disclosure provides vaccine formulations comprising at least one peptide antigen assembly and at least one adjuvant. The disclosure also provides methods of inducing an immune response in a mammal and methods of treating a disease in a mammal utilizing the vaccine formulations.

Abstract: In order to obtain crack-free, homogeneous welds in nickel-based superalloys, laser parameters in respect of the power, the beam diameter, the mass feed rate, and the speed of advancement, are specifically selected.

Abstract: A doorbell system can include a doorbell and a chime. The chime can emit a notification sound in response to a visitor pressing a button of the doorbell. Electrical switches can be electrically coupled between the doorbell and the chime to control the flow of electricity to the chime. In some embodiments, the switches prevent the chime from emitting notification sounds.

Abstract: The present invention includes compounds that are useful for treating or preventing a HIV-1 infection in a mammal. In certain embodiments, the compounds cause cell-free virolysis of an HIV-1 virus. The presented invention further includes a method of causing virolysis of a virus using the compounds described therein. The presented invention further includes a method of treating or preventing an HIV-1 infection in a mammal in need thereof using the compositions described therein.