Abstract: The present disclosure provides compositions and methods for controlling insect pests with bioactive agents. Also, the present disclosure provides insecticidal compositions and methods of using the formulations containing minicells and bioactive agents for targeted delivery and controlled release to enhance insect control in an environment-friendly, stable and scalable manner.

Abstract: The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body (1) which has an interior (2) for receiving a liquid (20), wherein the valve body (1) has a liquid inlet (3) and an opposite liquid outlet (4) which both open into the interior (2), wherein the interior (2) accommodates a large number of micro channels (5) which extend in connection direction (x) between the liquid inlet (3) and the liquid outlet (4). A corresponding device for administering a liquid medicament is also described.

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: Implants, devices, systems, and methods for achieving ligament fixation are disclosed. An implant comprises a cap member comprising an internally threaded opening extending from a first end thereof, an anchor portion comprising a first end that defines a tip of the implant and external threads, and a coupling portion extending between the cap member and the anchor portion. The coupling portion of the implant includes an externally threaded portion threadably coupled within the internally threaded opening of the cap member. The cap member of the implant is longitudinally moveable along the coupling portion. Insertion instruments for inserting an implant for ligament fixation are also disclosed. Methods of using an implant for achieving ligament fixation are also disclosed.

Abstract: Methods, systems, devices and apparatuses for a sound enhancement system. The sound enhancement system includes a trailer brake control unit placed on the vehicle and an electronic control unit coupled to the trailer brake control unit. The electronic control unit is configured to determine the vehicle is operating in a tow mode based on the trailer brake status, determine a magnitude of an audio signal that mimics or enhances engine sound based on the tow mode, and generate the audio signal. The sound enhancement system further includes an audio device configured to output the audio signal based at the determined magnitude.

Abstract: Disclosed are methods of treating an ocular disease associated with retinal ischemic injury in a subject comprising administering to the subject a p75NTR modulator, a MSC comprising decreased p75NTR expression or activity or a MSC secretome collected from a MSC comprising decreased p75NTR expression or activity. Disclosed are methods of treating late stage diabetes in a subject comprising administering to the subject in need thereof a p75NTR modulator, a MSC comprising decreased p75NTR expression or activity or a MSC secretome collected from a MSC comprising decreased p75NTR expression or activity.

Abstract: An assembly contains a disconnecting device for a surge-arresting device. A first contact and a second contact of the disconnecting device are connected by a first path having a switching element which can be thermally tripped. A second path is disposed electrically in parallel with the first path. An impedance element is disposed in the second path. A spark gap is disposed in the first path.

Abstract: Methods and devices for evaluating viability and/or degree of contamination of cells cultured in a reactor, which includes providing luminescent dye in the reactor whose luminescence anisotropy is influenced by the viability or the degree of contamination of the cells, exciting the luminescent dye to luminesce by irradiating polarized light into the medium. polarizing light emitted by the luminescent dye that leaves the medium, and detecting the polarized emitted light with a light sensor, where the polarized emitted light is detected as at least two luminescence values in at least two different polarization angles, and determining at least one anisotropy value from the at least two luminescence values by means of mathematical methods, which correlates with the viability or the degree of contamination of the cells.

Abstract: A number of systems and methods described here are directed to controlling, activating, and otherwise interacting with the phrenic nerve of a patient while the patient is undergoing mechanical ventilation, thus interacting with the diaphragm. Some embodiments of the systems and methods described herein are configured to achieve phrenic nerve stimulation in a controlled manner so as to sufficiently adapt the breathing therapy to a variety of patients.

Abstract: The present disclosure relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to the combined use of a PD-1 inhibitor, a TGF-beta inhibitor, and a MCT4 inhibitor to treat cancer.

Abstract: A method for producing a screw connection having a screw that is set in rotational motion with a screwdriving head of a screwdriving tool. The screwdriving head has a motor drive for creating the rotational motion of a screw receptacle of the screwdriving head. The screw is driven into at least one mating part of the screw connection in a rapid speed. A torque is detected with which the screw is driven. The rapid speed with a higher rotational speed is changed to a creep speed with a lower rotational speed at a changeover time. The changeover time is determined as a function of the detected torque during screwdriving at rapid speed. The screw is further driven at the creep speed until a head contact time when a head of the screw makes contact on the mating part.

Abstract: A transparent resistive pressure sensor and method of making the same are disclosed. The transparent resistive pressure sensor may include a flexible pressure substrate, a pressure electrode layer, an elastic dielectric spacer with microstructure, a transparent pressure-sensitive composite layer composed of a transparent polymer dielectric matrix and a conductive one-dimensional nanomaterial oriented substantially in a thickness direction of the transparent pressure-sensitive composite layer, a support electrode layer, and a support substrate.

Abstract: A method for evaluating the effectiveness of a skin treatment on a skin feature includes correcting the color of a first image before the skin treatment, correcting the color of a second image after the skin treatment, determining the sizes of the skin feature in the first and second images, and comparing the corrected colors and sizes of the skin feature in the first and second images. In some embodiments, the first and second images include the skin feature and an indicator adjacent to the skin feature, where the indicator has a standard color and a known size.

Abstract: A method of attaching at least two pieces of fabric in a waterproof fabric product. The at least two pieces of fabric are attached at a seam. The seam subsequently is sealed by application of a sealing tape. The method includes attaching the at least two pieces of fabric to each other by a welding process to form a welded seam, and performing the sealing by applying the sealing tape to cover the welded seam at one side of the fabric. A waterproof fabric product that has been produced using the method of attaching at least two pieces of fabric. A footwear includes a membrane including at least two pieces of fabric that are attached at a seam.

Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: A downhole tool for use in a well comprising a mandrel and an outer sleeve slidably disposed about the mandrel. An inner sleeve is slidably disposed in the mandrel. A drive pin comprising a drive pin bushing connected to the outer sleeve and a shear pin connected to the inner sleeve connects the inner sleeve to the outer sleeve.

Abstract: A method for operating a motor vehicle includes the steps of registering a maximum dynamics requirement and adapting the idling operating mode of a fuel cell system of the motor vehicle on the basis of the maximum dynamics requirement. In the first maximum dynamics requirement, lower dynamics are required than in the second maximum dynamics requirement. In the first maximum dynamics requirement, the fuel cell system is operated in a first idling operating mode. In the second maximum dynamics requirement the fuel cell system is operated in a second idling operating mode. The fuel cell system is operated more efficiently in the first idling operating mode than in the second idling operating mode.

Abstract: The invention relates to a method for checking a time-discrete signal value of a sensor for freedom from errors, wherein the signal value of the sensor is converted into a first measured value and a second measured value by two different evaluating devices of an electronic system, wherein the first and second measured values are transmitted to a control system by the electronic system, and the control system calculates a first control signal from the first measured value and, in parallel thereto, a second control signal from the second measured value, wherein the control system comprises a comparator which compares the first control signal and second control signal to verify the identity thereof.

Abstract: A cable hanger for the solar, mining, and electrical industry for use in supporting a plurality of conductive cables from a messenger wire.

Abstract: Systems and methods for access control systems includes first and second access facilities, and first and second readers. The first reader is configured to control access through the first access facility, receive a credential using a first communication protocol from a device that stores the credential, and establish a secret with the device using the credential. The second reader is configured to control access through the second access facility. The first reader is configured to provide the secret to the second reader, and the second device is further configured to perform ranging using the secret and a second communication protocol different than the first communication protocol to identify intent information. Access through one of the first facility or the second facility is coordinated using the intent information.