Abstract: Pyrimido[5,4-d]pyrimidines of the general formula ##STR1## which have an inhibitory effect on signal transduction mediated by tyrosine kinases, their use for the treatment of oncoses, and their preparation. Exemplary compounds are:(a) 4-(5-indolylamino)-6-morpholinopyrimido[5,4-d]pyrimidine;(b) 4-(5-indolylamino)-6-[trans-(4-hydroxycyclohexyl)amino]pyrimido[5,4-d]pyri midine;(c) 4-[(3-chloro-4-fluorophenyl)amino]-6-[4-(morpholinocarbonylmethyl)-1-piper azinyl]pyrimido[5,4-d]pyrimidine;(d) 4-[(3-chloro-4-fluorophenyl)amino]-6-[(4-morpholinyl)amino]pyrimido[5,4-d] pyrimidine;(e) 4-[(3-chloro-4-fluorophenyl)amino]-6-(4-picolylamino)pyrimido[5,4-d]pyrimi dine;(f) 4-[(3-chloro-4-fluorophenyl)amino]-6-[1-trifluoroacetyl-4-piperidinylamino ]pyrimido[5,4-d]pyrimidine;(g) 4-[(3-chloro-4-fluorophenyl)amino]-6-(endo-tropinylamino)pyrimido[5,4-d]py rimidine; and,(h) 4-[(3-chloro-4-fluorophenyl)amino]-6-(exo-tropinylamino)pyrimido[5,4-d]pyr imidine.

Abstract: Apparatus and methods for supplying a portion of a fluid stream and, alternately, a fluid of known composition and concentration to an analyzer are provided. The fluid stream is directed through a series of connected chambers formed in an integral housing. A sampling needle has an inlet in one of the chambers and an outlet in fluid communication with the analyzer. When desired, a tube or vial containing a known fluid may be inserted into a chamber containing the sampling needle, so that the known fluid will be supplied to the analyzer. A second needle provides ventilation to the vial to prevent the formation of a vacuum as the known fluid is drained from the vial.

Abstract: A sound engine in a processor-based system utilizing real-time synthesis optimizes synthesis time, maximizes the number of fully-synthesized sound requests and preserves currently excessive sound requests. During synthesis, the sound engine attempts to full-synthesize all requests. If the sound engine determines that remaining sound requests are excessive and cannot be fully-synthesized, it preserves each excessive request by synthesizing a substitute waveform segment. If the sound engine determines that limiting the number of preserved requests is required, it synthesizes a concluding waveform segment for and then discards selected requests during selected synthesis intervals. Both substitute-synthesis and discarding of sound requests are achieved with minimized detrimental impact on ongoing sound performances.

Abstract: The bypass clutch in the fluid-containing housing of the hydrokinetic torque converter in the power train of a motor vehicle is provided with a first friction surface carried by a radially extending or conical section of the housing, and with a complementary friction surface carried by an axially movable piston or by an intermediate clutch plate of the bypass clutch. At least one of the friction surfaces is provided with an array of pockets and/or channels for a fluid (such as oil) which withdraws friction heat developing when the bypass clutch is partially engaged so that the friction surfaces contact but slip relative to each other. The depth and/or the width of the channels is at least substantially constant, and such channels can include bends between straight channel sections. The inlets of the channels can be located at the radially inner or radially outer marginal portion and their outlets can be located at the radially outer or inner marginal portion of the respective friction surface.

Abstract: The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, and/or antibodies as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

Abstract: Methods and apparatus for converting a relatively low frequency signal, e.g., a 1.5 MHz signal, to a high frequency signal, e.g., a 30-100 MHz signal, in the digital domain without the need for a digital mixer operating at the high frequency are described. The high frequency represents, e.g., the ultimate digital to analog conversion frequency. In accordance with the present invention an interpolation technique is used to convert the low rate digital signal to a high rate signal and to shift the carrier to a desired frequency. This is accomplished, by first positioning the information signal, e.g., the digital waveform to be modulated on a carrier at a relatively low rate using a digital mixer operating at a fraction of the ultimate digital to analog conversion frequency. The relatively low rate signal generated by the mixing operation is then converted to a high rate signal by one or more interpolator stages. An adjustable passband filter circuit is included in each interpolation stage.

Abstract: The turnable connections for pipes and hoses mainly consist of connection nipples which can be linked to the end of these connections and which are partly amable as well as equipped with at least one sealing ring and a connection nipple with a union nut, with the amable tap-type connection nipple showing two ball-shaped bulged sections with different radii but the same center as well as a union not corresponding with the ball-shaped section and the overall sleeve-type connection nipple having a thread on the outer surface, which as well has a corresponding ball-shaped section with the same center M.

Abstract: An ultrasonic angle-beam probe and a method for operating the angle-beam probe include an approach wedge to be driven into a gap. The overall height of the probe sets limits which preclude testing starting from a specific gap width. At least two approach wedges are provided in order to give the angle-beam probe a testing sensitivity that is maintained even in the case of a reduced overall height. A device is provided which can be assigned to a pulse generator, a sound evaluator or a connecting element to a sound transducer, in order to influence a sound echo time.

Abstract: In accordance with the teachings of the present invention, a subterranean water and air collection and delivery device for facilitating the collection and delivery of air, natural ground water, manually supplied water, and/or pressurized water from an irrigation system to the roots of plants is provided. The device includes a plastic enclosure member including a plurality of apertures and having an interior volume within which water and air is collected and redirected. A porous insert member is located within the interior volume of the plastic enclosure member and substantially occupies the entire volume for facilitating collection and delivery of water and air while substantially preventing surrounding ground material from entering the interior volume of the enclosure member.

Abstract: A filter standpipe is mounted within a relief conduit of a cryopump. The relief conduit is joined to an exhaust conduit, and the exhaust conduit is joined to a housing which defines a vacuum chamber. The relief conduit and exhaust conduit define passages which are in fluid communication with one another and also with the vacuum chamber. The filter standpipe extends, from where it is mounted in the relief passage into the exhaust passage. A method for installing the filter standpipe includes the steps of removing a relief valve from a mount on the end of the relief conduit, inserting the filter standpipe through the mount, and remounting the relief valve.

Abstract: A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R.sup.1 NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.2 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.

Abstract: A note acceptor security system includes a currency validator secured to a housing and a note stacker removably received thereby. The currency validator has an identification chip maintained in association therewith and having a fixed serial number. The currency validator also includes a microprocessor which controls the operation of the currency validator and maintains operational data respecting the same. The stacker has a memory chip which is urged into a grounded position which is removed when the stacker is placed into the note acceptor. A fixed probe within the note acceptor lifts the memory chip from ground and allows communication from the microprocessor and identification chip to the memory chip. When the stacker is full, it is removed from the note acceptor and, with the memory chip grounded, it is transported to a docking station where the memory chip is again probed and the data maintained therein is transferred to a personal computer for later use.

Abstract: To provide controlled amounts of resistance to movement in exercise equipment or in orthotic devices, a control module has cooperating resistance elements. The force between the elements is varied in accordance with the position of the elements with respect to each other. For example the control module can connect two splints of a knee brace so that the resistance to flexion and extension are programmed in accordance with the position of the leg and thigh with respect to each other.

Abstract: In accordance with the present invention an interpolation technique is used to convert a low rate digital signal to a high rate signal and to shift the carrier to a desired frequency. This is accomplished, by first positioning the information signal, e.g., the digital waveform to be modulated on a carrier at a relatively low rate using a digital mixer operating at a fraction of the ultimate digital to analog conversion frequency. The relatively low rate signal generated by the mixing operation is then converted to a high rate signal by one or more interpolator stages. An adjustable passband filter circuit is included in each interpolation stage. One feature of the present invention is directed to a control circuit which is response to an H bit frequency control word representing a desired output carrier frequency. The control circuit generates individual filter control signals for each adjustable filter circuit from the single H bit frequency control word.

Abstract: A firearm safety mechanism having a self-contained locking mechanism incorporated into the magazine of a semi-automatic pistol which inhibits use of the firearm when a locking mechanism disarms the firing mechanism as well as locking the magazine in position so as to prevent unauthorized replacement. The firearm can be locked against unauthorized use and unlocked by an authorized user without resort to external accessories.

Abstract: Liquid antacid compositions containing a tri- or di-ester buffer have a reduced final product pH providing for a more efficacious preservative system and better tasting product without compromising to acid neutralization capacity of the antacid.

Abstract: An apparatus and method are implemented to track and manage system cycles stolen from a data processor by other processors in a multiprocessor data processor system. The apparatus and method maximize data throughput and minimize unused cycle resources within the multiprocessor data processing system.

Abstract: An industrial robot has a mounting bracket and a servo motor secured to the mounting bracket for rotation relative thereto about a first axis offset from the vertical by 60.degree.. A sensor plate is mounted on one end of the motor, a position sensor is mounted on the bracket and interacts with the sensor plate to sense the rotational home and overtravel positions of the motor. A tool changer is coaxially mounted on the other end of the motor and has means for mounting a turret for coaxial rotation by the motor. A turret having a plurality of circumferentially-spaced tools is mounted on the tool changer for operation on a second axis offset 60.degree. from the first axis, such that each tool is rotatable about the first axis to a vertical working position.

Abstract: A system that provides secure transmission of data between a subscriber's PC and an online service provider (OLS) over an Ethernet WAN. The system includes a remote transceiver unit located at a subscriber site and connected to the subscriber's PC; a central transceiver unit located at a telephone central office and connected to the remote transceiver unit over a twisted pair network and also connected to a WAN; an authorization server that is connected to the WAN; and one or more OLSs, which may include Internet service providers, connected to the WAN. Security of transmission is provided through a method in which only subscriber transmissions directed to a session-specific OLS are allowed to pass through the central transceiver unit onto the WAN, and only unicast transmissions from authorized OLSs are allowed to pass through the central transceiver unit to the subscriber port of the remote transceiver unit. Broadcast transmissions are minimized in favor of unicast messages.

Abstract: A detergent composition suitable for washing colored fabrics. The composition comprises:a) a N-vinylimidazole N-vinylpyrrolidone copolymer (PVP/PVI) in an amount effective to inhibit dye transfer between fabrics during the wash; andb) an organic surfactant system comprising(i) alkylbenzene sulphonate,(ii) a nonionic surfactantin which the ratio of (i) to (ii) is from 7:3 to 99:1.