Abstract: A pharmaceutical composition for use in treating hepatitis B virus (HBV) infection includes an effective amount of an antibody against CD11b or a binding fragment thereof. A method for treating hepatitis B virus infection includes administering to a subject in need thereof an antibody against CD11b. Anti-CD11b antibody binding to CD11b may trigger immunostimulatory responses, as evidenced by the following observations: increased surface expression of MHC II and CD86 in CD11b+ peripheral blood mononuclear cells (PBMCs); suppressed level of hepatitis B surface antigen (HBsAg) and HBV DNA in the blood; and accelerated clearance of HBV from liver.

Abstract: A method of the invention comprises obtaining training dental CT scans, identifying individual teeth and jaw bone in each of these CT scans, and training a deep neural network with training input data obtained from these CT scans and training target data. A further method of the invention comprises obtaining a patient dental CT scan, identifying individual teeth and jaw bone in this CT scan and using the trained deep learning network to determine a desired final position from input data obtained from this CT scan. The (training) input data represents all teeth and the entire alveolar process and identifies the individual teeth and the jaw bone. The determined desired final positions are used to determine a sequence of desired intermediate positions per tooth and the intermediate and final positions and attachment types are used to create three-dimensional representations of teeth and/or aligners.

Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.

Abstract: A silicon chip carrier includes at least two of a photosensitive P-I-N diode, a non-photosensitive P-I-N diode, a photosensitive P-(metal)-N diode, a non-photosensitive P-(metal)-N diode, and a Schottky diode all integrally formed in the same layers of the chip carrier. In some embodiments, diodes formed in the chip carrier provide photovoltaic power and power regulation to a circuit mounted on the chip carrier.

Abstract: An equipment inspection system receives data captured by a sensor of an autonomous vehicle (AV). The captured data describes a current state of equipment for servicing the AV. The equipment inspection system compares the captured data to a model describing an expected state of the equipment. The equipment inspection system determines, based on the comparison, that the equipment differs from the expected state. The equipment inspection system may transmit data describing the current state of the equipment to an equipment manager. The equipment manager may schedule maintenance for the equipment based on the current state of the equipment.

Abstract: A computer-implemented method for obtaining an adversarial input signal to a classifier for classifying input signals obtained from a sensor. The adversarial input signal is obtained from an original input signal. The adversarial input signal and the original input signal cause the classifier to classify the original input signal as belonging to a first class and the adversarial input signal as belonging to a second class different from said first class. The method includes: modifying said original input signal to yield a modified input signal; projecting said modified input signal onto a metric ball around said original input signal to yield a projected input signal; and obtaining said adversarial input signal depending on the projected input signal, characterized in that the metric is an at least approximate Wasserstein distance.

Abstract: The inventive disclosures described herein pertains to an improved clasp-type device for connecting two ends of a wrap-around personal-adornment/jewelry item, such as a necklace, bracelet, or anklet. The improved jewelry clasp provides for both easy and secure coupling of two ends of a wrap-around jewelry item, while providing a decorative “hiding” of the clasp. In variations, the improved jewelry clasp can appear as just one of several ingots/charms that the wrap-around jewelry item may contain. Various other practical applications of the improved jewelry clasp are also disclosed.

Abstract: Various examples are directed to systems and methods for authorizing a human user to execute transaction at a physical location. A location computing system may receive payment receipt data comprising an indication of a payment made from an account associated with a transaction party to an account associated with the location, and token data associated with the transaction. Based at least in part on the payment receipt data, the location computing system may determine to authorize execution of the transaction with a human user physically present at the location and generate an authorization output indicating that execution of the transaction with the human user is authorized.

Abstract: A method for producing a surroundings map of a transportation vehicle textured with image information, including detecting at least first and second image information from vehicle surroundings using at least one transportation vehicle-mounted camera device; producing a surroundings map of the transportation vehicle; determining at least one area of the surroundings map in which both the first and second sets of image information are present; and selecting either the first or the second set of image information for texturing the area of the surroundings map according to at least one of the following criteria: selecting the image information with the highest resolution and selecting the latest image information. Also disclosed is an arrangement for producing a surroundings map of a transportation vehicle textured with image information and a transportation vehicle having the arrangement.

Abstract: In one embodiment, a method includes receiving sensor data from a sensor array of a vehicle while traveling on a road. The method includes determining a confidence score for a classification of an object based on the sensor data. The method includes generating an object graphic corresponding to the object based on the confidence score for the classification of the object. The method includes retrieving, from one or more third-party systems, third-party data associated with an environment in proximity to the object and associated with the road based on the classification. The method includes generating an overlay graphic corresponding to the environment in proximity to the object based on the third-party data. The method includes providing for display the object graphic rendered in association with the overlay graphic corresponding to the environment.

Abstract: The invention relates to a sandwich composite component (1) for the interior of a passenger aircraft. One problem to be solved by the invention is that of proposing a cost-effectively produced sandwich composite component which is suitable for the interior of a passenger aircraft and fulfils current fire protection requirements. The layer structure of the sandwich composite component (1) according to the invention comprises: a core layer (10) made of polymer foam; a reinforcing layer (20) comprising fiber composite material; and in addition at least one functional layer (50); wherein said layers of the layer structure are integrally bonded to each other, in particular by an adhesive bond. The fiber composite material of the reinforcing layer (20) comprises a woven or laid fabric made of reinforcing fibers and a polymer matrix, which has a higher density than the polymer foam of the core layer (10).

Abstract: A haptic keyboard of an information handling system comprising a coversheet to identify keys of the haptic keyboard, a contact foil and a piezoelectric element to receive an applied mechanical stress at a first key of the coversheet and generate an electric actuation signal. A processor executing instructions of a haptic smart typing assistance system to detect and anticipate a next letter of a word being typed and a controller to receive an instruction of the anticipated next letter and increasing force required actuate at least one key for a letter adjacent to the anticipated next letter, and to send a response haptic feedback control signal to the piezoelectric element to cause the piezoelectric element to generate a first haptic feedback at the first key if the anticipated next letter is selected and to generate a second haptic feedback if a typographical error is detected.

Abstract: Systems and methods for establishing communication connections using speech, such as establishing calls between speech-controlled devices, are described. A first speech-controlled device receives a communication request in the form of audio and sends audio data corresponding to the captured audio to a server. The server performs speech processing on the audio data to determine a recipient, a subject for the call, and a device associated with the recipient. The server then sends a message indicating the communication request and audio data corresponding to the communication topic to the recipient's speech-controlled device. The recipient device outputs audio to the recipient requesting whether the recipient accepts the communication request. The recipient audibly refuses or accepts the communication request, and the recipient's speech-controlled device sends an indication of the recipient's audible decision to the server.

Abstract: The invention provides an optical system and method for outputting a modulated signal comprising a single multimode interference (MMI) device having at least two inputs configured with a fixed phase and an output, wherein the output modulated signal is controlled by modulating the input power of at 5 least one of the inputs. The invention only requires a single MMI device to operate as the relative phase between the two inputs are fixed relative each other and one of the inputs can be used to modulate the output by modulating the power at a single input. In further embodiments, the invention shows how correct phases can be set by a single MMI device. Thus, no more than two 10 MMIs are required in conjunction with phase or amplitude modulating elements to fully generate a BPSK or QPSK signal.

Abstract: A fiber scanning projector includes a piezoelectric element and a scanning fiber passing through and mechanically coupled to the piezoelectric element. The scanning fiber emits light propagating along an optical path. The fiber scanning projector also includes a first polarization sensitive reflector disposed along and perpendicular to the optical path, a quarter wave plate disposed adjacent the first polarization sensitive reflector, and a second polarization sensitive reflector disposed along and perpendicular to the optical path.

Abstract: Tuning information associated with a storage device of a plurality of storage devices is received. One or more characteristics associated with the storage device are determined. The tuning information and the one or more characteristics are provided to the plurality of storage devices, wherein providing the tuning information causes a set of the plurality of storage devices to apply the tuning information based on the one or more characteristics.

Abstract: Compounds of formula (I): wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a —COOH, a —OH or a —OPO(OH)2 group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or a —OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a —COOH, —OH or —OPO(OH)2 group, then R5 represents a hydrogen atom; when R5 represents a —OH group, then R3 and R4 represent hydrogen atoms; and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl and heterocycloalkyl group; and the preparation and the therapeutic uses of the compounds of formula (I) as inhibitors and degraders of estrogen receptors, useful especially in the treatment of cancer.

Abstract: The invention relates to a method for ascertaining a rough trajectory from a specified contour for controlling a machine tool which has at least two mutually redundant drive devices for carrying out superimposed movements, wherein the contour is determined by a contour function (Pj, pj) which is defined in portions by contour nodal points P0?Pn+1 and respective contour portion functions p0?pn, wherein a respective contour portion function pj connects two adjacent contour nodal points Pj, Pj+1, wherein the rough trajectory is determined by a rough trajectory function (Qj, qj) which is defined in portions by rough trajectory nodal points Q0?Qn+1 and respective rough trajectory portion functions q0?qn, wherein a respective rough trajectory portion function q connects two adjacent rough trajectory nodal points Qj, Qj+1, wherein, for each contour nodal point Pj, a respective assigned rough trajectory nodal point Qj is ascertained in such a manner that a difference in the gradients of the two adjacent rough traject

Abstract: A substance delivery device is disclosed. The substance delivery device includes a lever that includes a drive arm that is rotatable about a pivot. The substance delivery device also includes a pump that has a deformable chamber. The deformable chamber is configured to rotate the drive arm about the pivot towards a container so as to deform the container to drive a fluid substance from the container.

Abstract: The invention relates to a plasma torch, in particular plasma cutting torch, in which at least one secondary medium is guided by at least one feeder through a housing of the plasma torch to a nozzle protection cap opening and/or to further openings that are provided in a nozzle protection cap. In the at least one feeder, at least one valve for opening and closing the feeder is provided directly within the housing of the plasma torch.