Abstract: A safety system for a power miter saw comprises a support member, at least one multidirectional manipulator including a workpiece holder member moveably mounted to the support member for securing a workpiece in place, and a control box. The workpiece holder member includes a presence indicator operatively connected to the control box and configured to detect the physical presence of a saw operator's hand on the at least one multidirectional manipulator when the saw operator's hand engages the presence indicator. The control box is operatively connectable to a trigger switch of the power miter saw so that an electric motor of the power miter saw is activated only when both the presence indicator of the safety system and the trigger switch of the power miter saw are engaged by both hands of an operator of the power miter saw.

Abstract: The present invention relates to a method for inspecting a component, in particular a component of a turbomachine (1), including the steps of: capturing (S2) at least one X-ray or CT image of the component (10) using an image-capturing device (20); providing (S21) metadata about the component (10), the metadata including, in particular, a component type, a running time of the component (10), a number of remaining life cycles, and/or a repair history; classifying, by a machine learning system (30), the component (10) into a “serviceable” category or a “non-serviceable” category based on the image captured by the image-capturing device (20) and the provided metadata.

Abstract: Disclosed herein are methods for selecting tumor-specific neoantigens from a tumor of a subject that are suitable for subject-specific immunogenic compositions.

Abstract: Disclosed herein are methods for selecting one or more tumor-specific neoantigens from a tumor of a subject for a personalized immunogenic composition. Also disclosed herein are methods for treating cancer in a subject in need thereof by administering an immunogenic composition comprising tumor-specific neoantigens selected using the methods disclosed herein.

Abstract: Provided herein are immunogenic compositions comprising tumor-specific neoantigen long peptides, tumor-specific neoantigen short peptides, and adjuvant, optionally a helper peptide, and optionally a tumor-specific peptide. The disclosure also provides methods of using these immunogenic compositions for treating cancer.

Abstract: Disclosed herein are methods for ranking tumor-specific neoantigens from a tumor of a subject that are suitable for subject-specific immunogenic compositions. Suitable tumor-specific neoantigens are tumor-specific neoantigens that are likely presented on the cell surface of the tumor, are likely to be immunogenic, are predicted to be expressed in sufficient amounts to elicit an immune response in the subject, optionally represent sufficient diversity across the tumor, and have relatively high manufacture feasibility. The present methods take a set of neoantigens (peptide vaccine candidates) and ranks the neoantigens in a way such that a group of top-ranked neoantigens simultaneously promotes cell-surface presentation of important neoantigens for Class I and Class II MHC molecules. The top-ranked neoantigens can then be further narrowed according manufacturability and/or other criteria.

Abstract: A thermoplastic polyurethane resin composition comprising: a thermoplastic polyurethane resin; an ultraviolet absorber package comprising a benzotriazole compound (UVA1), and a triazine compound (UVA2) wherein the mass ratio of UVA1 to UVA2 is from 1:1 to 3:1; optionally, a hindered amine light stabilizer and/or an antioxidant compound; and wherein the thermoplastic polyurethane resin composition has a maximum ultraviolet transmittance of ?3% in the wavelengths between 280 nm and 365 nm and an ultraviolet transmittance of ?6% in the wavelengths between 365 nm and 370 nm when the thermoplastic polyurethane resin is formed into a film having a thickness of 6 mils and wherein the cumulative weight % of UVA1 and UVA2 in the polyurethane resin composition ranges from 0.5 wt % to 0.85 wt % based on the total weight of the polyurethane resin composition.

Abstract: The invention relates to a disc brake, comprising a brake carrier, a brake caliper, brake shoes, and an actuating piston. The brake carrier has at least one mounting point for mounting on a vehicle. The actuating piston is displaceably accommodated on the brake caliper and is actuatable for carrying out a service brake function of the disc brake. At least one further actuating piston is provided, which in the direction of its longitudinal axis is displaceably accommodated on the brake caliper. For carrying out the service brake function, the at least two actuating pistons are actuatable, and for carrying out a parking brake function, one of the actuating pistons is actuatable. The invention further relates to a disc brake system and a parking brake system.

Abstract: Techniques are described and relate to assigning peptides to peptide groups for vaccine development. In an example, a peptide property of a peptide is determined, where this peptide is from different peptides that are to be assigned to different groups of vaccine. A determination is also made that the peptide is to be assigned to a first group from the different groups based at least in part on the peptide property. The first group has a first group property that is based at least in part on peptide properties of first peptides to be assigned to the first group. The first group property is within a similarity range relative to a second group property of a second group from the different groups. Information is generated and indicates that the peptide is assigned to the first group.

Abstract: A safety system for a power miter saw comprises a support member, at least one multidirectional manipulator including a workpiece holder member moveably mounted to the support member for securing a workpiece in place, and a control box. The workpiece holder member includes a presence indicator operatively connected to the control box and configured to detect the physical presence of a saw operator's hand on the at least one multidirectional manipulator when the saw operator's hand engages the presence indicator. The control box is operatively connectable to a trigger switch of the power miter saw so that an electric motor of the power miter saw is activated only when both the presence indicator of the safety system and the trigger switch of the power miter saw are engaged by both hands of an operator of the power miter saw.

Abstract: A brake caliper arrangement includes a housing, a restoring device, a first brake lining arrangement and a second brake lining arrangement. The first brake lining arrangement and the second brake lining arrangement can be moved relative to one another from a respective starting position with a reduction of an initial spacing which exists between them. The restoring device includes first and second restoring elements. The first restoring element may prestress the first brake lining arrangement into its starting position, while the second restoring element may prestress the second brake lining arrangement into its starting position. The first and/or second restoring elements may be supported, on both sides of a central region of the brake lining arrangement, on the associated brake lining arrangement. The first and/or second restoring elements may be twisted elastically at least in sections in order to generate the prestress.

Abstract: A riveted joint comprising: an upper workpiece and a lower workpiece, and a self-piercing rivet. The rivet in an undeformed state, before the creation of the riveted joint, included: a head defining a head diameter (DH); a shank defining a shank diameter (DS); and a foot end opposite the head. Radially outward at the foot end is a flat surface facing away from the head; and an axial recess located radially inward of the flat surface, partly defined in the foot end, open axially away from the head, and frustoconical in longitudinal cross section. The axial recess defining an axial depth (LB). The ratio of recess axial depth (LB) to shank diameter (DS) is less than 0.3. And in a deformed state, after the creation of the riveted joint, the rivet extends through the first workpiece and penetrates the second workpiece; and the head bears against the upper surface.

Abstract: A punch rivet for joining two workpieces, has a head and a shank. The shank is hollow with a shank internal diameter (D3), a shank external diameter (D1) and a shank end face. On the shank end face is a ring cutting edge with diameter (D4) that is smaller than the external diameter (D1) but greater than the internal diameter (D3). The ring cutting edge is radially spaced both from the shank external diameter (D1) and from the shank internal diameter (D3) by at least 20% of the radial shank wall thickness (M5). And the ratio D3/D1 of shank internal diameter D3 to shank external diameter D1 is smaller than 0.6. And the external diameter (D1) merges into an external circumference of the head by a second profile, which defines an underhead radius (R1), and the ratio of R1 to D1 (R1/D1) is smaller than 0.13.

Abstract: A brake caliper arrangement includes a housing, a restoring device, a first brake lining arrangement and a second brake lining arrangement. The first brake lining arrangement and the second brake lining arrangement can be moved relative to one another from a respective starting position with a reduction of an initial spacing which exists between them. The restoring device includes first and second restoring elements. The first restoring element may prestress the first brake lining arrangement into its starting position, while the second restoring element may prestress the second brake lining arrangement into its starting position. The first and/or second restoring elements may be supported, on both sides of a central region of the brake lining arrangement, on the associated brake lining arrangement. The first and/or second restoring elements may be twisted elastically at least in sections in order to generate the prestress.

Abstract: The invention relates to a disc brake, comprising a brake carrier, a brake caliper, brake shoes, and an actuating piston. The brake carrier has at least one mounting point for mounting on a vehicle. The actuating piston is displaceably accommodated on the brake caliper and is actuatable for carrying out a service brake function of the disc brake. At least one further actuating piston is provided, which in the direction of its longitudinal axis is displaceably accommodated on the brake caliper. For carrying out the service brake function, the at least two actuating pistons are actuatable, and for carrying out a parking brake function, one of the actuating pistons is actuatable. The invention further relates to a disc brake system and a parking brake system.

Abstract: A riveted joint comprising: an upper workpiece and a lower workpiece, and a self-piercing rivet. The rivet in an undeformed state, before the creation of the riveted joint, included: a head defining a head diameter (DH); a shank defining a shank diameter (DS); and a foot end opposite the head. Radially outward at the foot end is a flat surface facing away from the head; and an axial recess located radially inward of the flat surface, partly defined in the foot end, open axially away from the head, and frustoconical in longitudinal cross section. The axial recess defining an axial depth (LB). The ratio of recess axial depth (LB) to shank diameter (DS) is less than 0.3. And in a deformed state, after the creation of the riveted joint, the rivet extends through the first workpiece and penetrates the second workpiece; and the head bears against the upper surface.

Abstract: A riveted joint comprising: an upper workpiece and a lower workpiece, and a self-piercing rivet. The rivet in an undeformed state, before the creation of the riveted joint, included: a head defining a head diameter (DH); a shank defining a shank diameter (DS); and a foot end opposite the head. Radially outward at the foot end is a flat surface facing away from the head; and an axial recess located radially inward of the flat surface, partly defined in the foot end, open axially away from the head, and frustoconical in longitudinal cross section. The axial recess defining an axial depth (LB). The ratio of recess axial depth (LB) to shank diameter (DS) is less than 0.3. And in a deformed state, after the creation of the riveted joint, the rivet extends through the first workpiece and penetrates the second workpiece; and the head bears against the upper surface.

Abstract: A punch rivet for joining two workpieces, has a head and a shank. The shank is hollow with a shank internal diameter (D3), a shank external diameter (D1) and a shank end face. On the shank end face is a ring cutting edge with diameter (D4) that is smaller than the external diameter (D1) but greater than the internal diameter (D3). The ring cutting edge is radially spaced both from the shank external diameter (D1) and from the shank internal diameter (D3) by at least 20% of the radial shank wall thickness (M5). And the ratio D3/D1 of shank internal diameter D3 to shank external diameter D1 is smaller than 0.6. And the external diameter (D1) merges into an external circumference of the head by a second profile, which defines an underhead radius (R1), and the ratio of R1 to D1 (R1/D1) is smaller than 0.13.

Abstract: A riveted joint comprising: an upper workpiece and a lower workpiece, and a self-piercing rivet. The rivet in an undeformed state, before the creation of the riveted joint, included: a head defining a head diameter (DH); a shank defining a shank diameter (DS); and a foot end opposite the head. Radially outward at the foot end is a flat surface facing away from the head; and an axial recess located radially inward of the flat surface, partly defined in the foot end, open axially away from the head, and frustoconical in longitudinal cross section. The axial recess defining an axial depth (LB). The ratio of recess axial depth (LB) to shank diameter (DS) is less than 0.3. And in a deformed state, after the creation of the riveted joint, the rivet extends through the first workpiece and penetrates the second workpiece; and the head bears against the upper surface.

Abstract: A riveted joint comprising: an upper workpiece and a lower workpiece, and a self-piercing rivet. The rivet in an undeformed state, before the creation of the riveted joint, included: a head defining a head diameter (DH); a shank defining a shank diameter (DS); and a foot end opposite the head. Radially outward at the foot end is a flat surface facing away from the head; and an axial recess located radially inward of the flat surface, partly defined in the foot end, open axially away from the head, and frustoconical in longitudinal cross section. The axial recess defining an axial depth (LB). The ratio of recess axial depth (LB) to shank diameter (DS) is less than 0.3. And in a deformed state, after the creation of the riveted joint, the rivet extends through the first workpiece and penetrates the second workpiece; and the head bears against the upper surface.