Patents by Inventor Frank Zenke

Frank Zenke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methylene urea derivatives
    Patent number: 7589112
    Abstract: The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: September 15, 2009
    Assignee: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Oliver Schadt, Christiane Amendt, Frank Zenke, Christian Sirrenberg, Matthias Grell, Dirk Finsinger
  • GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS
    Publication number: 20090163556
    Abstract: The present invention relates to glycinamide derivatives of formula I, A-D-B??(I), wherein A, D, and B are as herein defined, as well as the use of the compounds of formula I as inhibitors of raf-kinase, the use of the compounds of formula I for the manufacture of a pharmaceutical composition, and a method of treatment comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: November 18, 2008
    Publication date: June 25, 2009
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Oliver Schadt, Christiane Amendt, Frank Zenke, Christian Sirrenberg, Matthias Grell
  • Oxindoles as Kinase Inhibitors
    Publication number: 20090131506
    Abstract: The present invention relates to oxindoles of the formula I, their use as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases and their use for the manufacture of a pharmaceutical composition.
    Type: Application
    Filed: May 11, 2006
    Publication date: May 21, 2009
    Inventors: Lars Thore Burgdorf, David Bruge, Hartmut Greiner, Maria Kordowicz, Christian Sirrenberg, Frank Zenke
  • INDANES
    Publication number: 20090118267
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, and q have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: February 13, 2006
    Publication date: May 7, 2009
    Inventors: Dirk Finsinger, David Bruge, Hans-Peter Buchstaller, Ulrich Emde, Kai Schiemann, Wolfgang Staehle, Christiane Amendt, Nina Heiss, Frank Zenke
  • Tetrahydroquinolines
    Publication number: 20090030028
    Abstract: Disclosed are compounds of formula (I), wherein W, R, R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, among other things.
    Type: Application
    Filed: June 3, 2005
    Publication date: January 29, 2009
    Inventors: Kai Schiemann, David Bruge, Hans-Peter Buchstaller, Dirk Finsinger, Wolfgang Staehle, Christiane Amendt, Ulrich Emde, Frank Zenke
  • Glycinamide derivatives as raf-kinase inhibitors
    Patent number: 7476683
    Abstract: The present invention relates to glycinamide derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: January 13, 2009
    Assignee: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Oliver Schadt, Christiane Amendt, Frank Zenke, Christian Sirrenberg, Matthias Grell
  • Squaric Acid Derivatives as Protein Kinase Inhibitors
    Publication number: 20080312244
    Abstract: Compounds of the formula I, in which R, X, R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be employed, inter alia, for the treatment of cancer.
    Type: Application
    Filed: June 30, 2006
    Publication date: December 18, 2008
    Inventors: Werner Mederski, Ulrich Emde, Gerhard Barnickel, Frank Zenke, Hartmut Greiner, Frank Stieber
  • Squaric Acid Derivatives II
    Publication number: 20080234266
    Abstract: Compounds of the formula (I), in which R, X, X? and R2, R2?, R2?, R3?, R2?? and R7 have the meanings indicated in claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be employed, inter alia, for the treatment of cancer.
    Type: Application
    Filed: June 30, 2006
    Publication date: September 25, 2008
    Inventors: Werner Mederski, Ulrich Emde, Gerhard Barnickel, Frank Zenke, Hartmut Greiner, Frank Stieber
  • Tetrahydroquinoline Derivatives
    Publication number: 20080221118
    Abstract: Compounds of the formula I, in which s, k, I, W, R1, R2, R3, and U have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: May 31, 2006
    Publication date: September 11, 2008
    Inventors: Wolfgang Staehle, David Bruge, Kai Schiemann, Dirk Finsinger, Hans-Peter Buchstaller, Frank Zenke, Christiane Amendt
  • Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5
    Publication number: 20080200451
    Abstract: Compounds of the formula (I), in which W, R, R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: June 2, 2006
    Publication date: August 21, 2008
    Inventors: Kai Schiemann, David Bruge, Hans-Peter Buchstaller, Ulrich Emde, Dirk Finsinger, Christiane Amendt, Frank Zenke
  • Substituted Tetrahydroquinolines
    Publication number: 20080194615
    Abstract: Disclosed are compounds of formula (I), wherein W, R, R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, among other things.
    Type: Application
    Filed: May 17, 2006
    Publication date: August 14, 2008
    Applicant: Merck Patent GmbH
    Inventors: Kai Schiemann, Ulrich Emde, Dirk Finsinger, Christiane Amendt, Nina Heiss, Frank Zenke
  • Phthalazinones
    Publication number: 20080194569
    Abstract: Compounds of the formula I, in which R, R1, R2, R3, R4, R5, R6, R7, R8, Z1, Z2, Z3 and Y1 have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours
    Type: Application
    Filed: February 21, 2006
    Publication date: August 14, 2008
    Inventors: Hans-Peter Buchstaller, Dirk Finsinger, Kai Schiemann, Ulrich Emde, Frank Zenke, Christiane Amendt
  • Dihydrobenzothiophenes
    Publication number: 20070219246
    Abstract: Compounds of the formula (I) in which W, R1, R2, R3, R4, and q have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: April 28, 2005
    Publication date: September 20, 2007
    Inventors: Dirk Finsinger, Soheila Anzali, Matthias Frech, Johannes Gleitz, Nina Heiss, Bjoern Hock, Kai Schiemann, Frank Zenke
  • Malonamide Derivatives
    Publication number: 20070213374
    Abstract: The present invention relates to malonamide derivatives of formula A-D-B-1, as inhibitors of raf-kinase and the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition.
    Type: Application
    Filed: June 18, 2004
    Publication date: September 13, 2007
    Applicant: Merck Patent GmbH
    Inventors: David Bruge, Hans-Peter Buchstaller, Matthias Wiesner, Dirk Finsinger, Manfred Baumgarth, Christian Sirrenberg, Frank Zenke, Christian Amendt, Matthias Grell
  • Use of thiadiazoleurea derivatives
    Publication number: 20070191353
    Abstract: Use of compounds of the formula (I), in which Ar1, Ar2 and Z have the meanings indicated in Patent Claim 1, for the prophylaxis and/or treatment of diseases in which the inhibition, regulation and/or modulation of signal transduction by kinases, in particular RAF kinases, plays a role.
    Type: Application
    Filed: January 31, 2005
    Publication date: August 16, 2007
    Inventors: Lars Burgdorf, Frank Stieber, Hans-Peter Buchstaller, Soheila Anzali, Christiane Amendt, Hartmut Greiner, Matthias Grell, Christian Sirrenberg, Frank Zenke
  • Benzimidazolyl derivatives
    Publication number: 20070191444
    Abstract: The present invention relates to benzimidazolyl derivatives of formula (I), with the definition of R8, p, Ar1, E, D, R9, q and R10 according to claim 1, the use of the compounds of formula (I) as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: February 14, 2005
    Publication date: August 16, 2007
    Inventors: Hans-Peter Buchstaller, Lars Burgdorf, Frank Stieber, Christiane Amendt, Matthias Grell, Christian Sirrenberg, Frank Zenke
  • Isoquinoline derivatives
    Publication number: 20070191423
    Abstract: The present invention relates to isoquinoline derivatives of formula (I), the use of the compounds of formula (I), as inhibitors of one or more kinases, the use of the compounds of formula (I), for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: February 1, 2005
    Publication date: August 16, 2007
    Applicant: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Lars Burgdorf, Dirk Finsinger, Christiana Amendt, Matthias Grell, Christian Sirrenberg, Frank Zenke
  • Pyrrole derivatives
    Publication number: 20070149594
    Abstract: Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours
    Type: Application
    Filed: October 26, 2004
    Publication date: June 28, 2007
    Inventors: Dirk Finsinger, Hans-Peter Buchstaller, Lars Burgdorf, Matthias Wiesner, Christiane Amendt, Matthias Grell, Christian Sirrenberg, Frank Zenke
  • Pyridinamide derivatives as kinase inhibitors
    Publication number: 20070142440
    Abstract: The invention relates to substituted arylamide derivatives of the formula I, the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases that are caused, mediated and/or propagated by angiogenesis. Compounds of the formula I are effective inhibitors of tyrosine kinases, in particular TIE-2 and VEGFR, and of Raf kinases.
    Type: Application
    Filed: January 13, 2005
    Publication date: June 21, 2007
    Inventors: Lars Burgdorf, Hans-Peter Buchstaller, Frank Stieber, Christiane Amendt, Hartmut Greiner, Matthias Grell, Christ8an Sirrenberg, Frank Zenke
  • Benzimidazole carboxamides as raf kinase inhibitors
    Publication number: 20070093532
    Abstract: The present invention relates to benzimidazole carboxamides of formula (I), the use of the compounds of formula (I) as inhibitors of as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. Accordingly, the compound of Formula (I) or a pharmaceutically acceptable salt thereof is administered for the treatment of diseases mediated by one or more kinase phathways, preferably by the raf kinase pathway, especially cancers.
    Type: Application
    Filed: June 11, 2004
    Publication date: April 26, 2007
    Applicant: MERCK PATENT GmbH
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Frank Zenke, Christiane Amendt, Matthias Grell, Christian Sirrenberg