Patents by Inventor Frank Zhishi Xia

Frank Zhishi Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7219816
    Abstract: A pre-filled disposable pipette (10) consisting of a hollow bulb (12) dimensioned to enclose a medicinal product. From a lower end (16) of the bulb (12) is attached sequentially a medicinal transfer tube (24) and a medication fill tube (32), from where the medicinal product is applied. Between a lower end (28) of the tube (24) and an upper end (34) of the tube (32) is formed a break-away notch (40). When the tube (24) or the tube (32) is rotated, the notch (40) is twisted and breaks-off, thus allowing the medicinal product to flow from the bulb (12) and be released from the tube (24). The pipette (10) includes a primary grasping tab (46) attached to an upper end (14) of the bulb (12); a secondary grasping tab (54) attached to each side of the tube (24); and a support tab (70) attached to each side of the tube (32). The invention also discloses several methods for sealing the lower tip (36) of the medication fill tube (32).
    Type: Grant
    Filed: October 20, 2003
    Date of Patent: May 22, 2007
    Assignee: Amphastar Pharmaceuticals, Inc.
    Inventors: Frank Zhishi Xia, Jack Yongfeng Zhang, Mary Zi-Ping Luo
  • Patent number: 6827479
    Abstract: A uniform small particle homogenizer for liquid product comprising a pair of intensifier cylinder pumps (20) driven by a hydraulic system (22). The pumps have a power stroke side and a suction stroke side, and a pair of proximity sensors (24) that interface with each pump to detect forward and rearward movement. A microprocessor (26) with timing capabilities controls the sequential operation of each pump with the power stroke of each pump timed to alternately produce a flow of the liquid product with a precisely timed flow overlap period from the alternating pumps. Since the power stroke takes a longer time than the suction stroke, the instant each power stroke is started the opposite pump is timed to hesitate and slightly overlap until a constant product flow-rate is produced from the alternating pumps, which eliminates large variances in pressure and therefore achieves uniformity in product particle size.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: December 7, 2004
    Assignee: Amphastar Pharmaceuticals Inc.
    Inventors: Frank Zhishi Xia, Mary Ziping Luo, Jack Yongfeng Zhang
  • Patent number: 6551298
    Abstract: A controlled medicament security enclosure system that houses liquid filled reservoirs which consists of a portable enclosure (20) formed with a top half (22) and a bottom half (24) that permanently snap together to form a secure inseparable repository for the reservoirs. Inside the enclosure is at least one glass vial (36) for storing the liquid medicament with each vial having a sliding piston stopper (42) within that seals the inside of the vial and slides to maintain the liquid air free regardless of the volume. An adapter socket (48) is removably attached to the stopper and includes a hollow needle that pierces the stopper and permits a flowpath for the liquid. A flexible outlet tube (62) along with connectors on each end transmit the medicament to a mechanical drug delivery system that has a peristaltic pump and a control module.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: April 22, 2003
    Inventors: Jack Y. Zhang, Frank Zhishi Xia, Mary Ziping Luo
  • Patent number: 6457612
    Abstract: An improved pre-filled disposable pipette (10) consisting of a hollow tube (12) dimensioned to enclose a medicinal product and having attached a medication transfer tube (22) from where the pipette is filled and the medicinal product released. The improvement consists in having a primary grasping tab (32) attached to an upper end (14) of the bulb (12); a secondary grasping tab (38) attached to each side of the tube (22); and a support tab (52) also attached to each side of the tube (22) near the lower end (26) of the tube (22). The primary and secondary grasping tabs (32, 38) allow the pipette (10) to be conveniently and easily handled without having to grasp the sensitive bulb (12) or to directly grasp the tube (22). The support tab (52) functions to allow the pipette (10) to be placed on a conveyor rack apparatus (88) from where the pipette (10) can be automatically filled and sealed by a cap (72) or heat applied foil (82).
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: October 1, 2002
    Assignee: Amphastar Pharmaceuticals Inc.
    Inventors: Jack Yongfeng Zhang, Mary Zi-Ping Luo, Frank Zhishi Xia
  • Patent number: 6343717
    Abstract: A pre-filled disposable pipette for pharmaceutical and cosmetic products which has a hollow, round pipette body (40). The body consists of a hollow, rigid bulb section (44) forming a reservoir for storage and dispersion of the liquid pharmaceutical or cosmetic product which is pre-filled within the body. The body (40) further includes a hollow tubular section (46) that is smaller in diameter and contiguous with the bulb section, for ease of handling the pipette. The preferred embodiment has a hollow, frangible upper tube (42) with a distal end that is sealed for introducing air into the body (40) when the seal is broken, thus releasing the liquid from the tubular section. The liquid is dispensed from the body by breaking the upper tube allowing air to enter the pipette with the liquid flowing by gravity. The second embodiment has a resilient bulb section and omits the upper tube. A tapered section (90) is added to the tubular section, with a hollow tip (86) on the end.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: February 5, 2002
    Inventors: Jack Yongfeng Zhang, Frank Zhishi Xia, Mary Ziping Luo
  • Patent number: 6139533
    Abstract: A hypodermic needle capping device (10) that attaches to a hypodermic syringe (100). The device (10) consists of two separate elements: the first consists of a collar (12) having integrally attached a snap-lock structure (24) that includes a locking barb (40) and slide member retaining structure (42). The second consists of a slide member (54) which includes a barb receiving and locking slot (58) and a needle point barrier (76). The collar (12) is frictionally inserted over the upper edge (108) of the syringe (100). The slide member (54) is slidably attached to the slide member retaining structure (42) and is designed to be placed in two positions. When the syringe (100) is to be used, the slide member (54) is positioned along the side of the syringe (100).
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: October 31, 2000
    Inventors: Frank Zhishi Xia, Gunther Maier, Jack Yongfeng Zhang, Mary Ziping Luo