Abstract: A tissue dispensing device for vehicles includes a body having a circumferential outer wall, a base wall, a top opening, an upper portion, a lower portion and a transition portion extending between and connecting the upper and lower portions, the body being generally hollow and a lid having a tissue release opening formed therein, the lid adapted to fit on and cover the top opening. The upper portion has a minimum circumference at least ten percent (10%) greater than the maximum circumference of the lower portion and the lower portion has a generally truncated cone shape such that as the lower portion is slid into a cup-holder, the sides of the cup-holder frictionally engage the lower portion to releasably secure the device within the cup-holder. Finally, a plurality of tissues is housed within the body in an interconnected manner for dispensing through the tissue dispensing opening of the lid.