Abstract: A surgical tissue ligation clip and an applicator device for delivery of multiple ligation clips is provided. The surgical ligation clips have first and second leg members joined by a resilient hinge at one end and a deflectable hook member and a locking element on the opposite end. The surgical tissue ligation clip has a proximal tissue shield that prevents tissue from being pinched at the hinge, and/or a distal tissue shield that prevents tissue from being pinched between the hook member and locking element and interfering with securely closing the ligation clip for implantation. A minimally invasive applicator for the surgical ligation clip is provided for delivering individually arranged ligation clips in line, incising target tissue and delivering a plurality of surgical ligation clips at the tissue site.