Patents by Inventor Franklin Grosveld

Franklin Grosveld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intracellular antibodies for a retrovirus protein
    Publication number: 20060150261
    Abstract: A transgenic organism is provided comprising a polynucleotide construct encoding an intracellular antibody which disrupts the catalysis of the production of the xenoantigen galactose ? 1,3 galactose and/or a polynucleotide construct which encodes an intracellular antibody which binds specifically to a retrovirus protein, such as a PERV particle protein. Also described are methods for the production of such organisms. Cells, tissues and organs of the transgenic organism may be used in xenotransplantation.
    Type: Application
    Filed: March 9, 2006
    Publication date: July 6, 2006
    Inventors: Dubravka Drabek, Sylvia Dekker, Franklin Grosveld
  • Intracellular antibodies for a retrovirus protein
    Publication number: 20050108780
    Abstract: A transgenic organism is provided comprising a polynucleotide construct encoding an intracellular antibody which disrupts the catalysis of the production of the xenoantigen galactose ? 1,3 galactose and/or a polynucleotide construct which encodes an intracellular antibody which binds specifically to a retrovirus protein, such as a PERV particle protein. Also described are methods for the production of such organisms. Cells, tissues and organs of the transgenic organism may be used in xenotransplantation.
    Type: Application
    Filed: July 19, 2004
    Publication date: May 19, 2005
    Inventors: Dubravka Drabek, Sylvia Dekker, Franklin Grosveld
  • Vector for integration site independent gene expression in mammalian host cells
    Patent number: 5849997
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 15, 1998
    Assignee: Medical Research Council Ltd.
    Inventors: Franklin Grosveld, Dimitris Kioussis
  • Targeting complexes and use thereof
    Patent number: 5849718
    Abstract: The invention relates to a composition including a targeting complex containing a component of an effector system and a ligand capable of targeting a cell surface marker in association with at least one further targeting complex containiing a further component of the effector system and a ligand capable of targeting a cell surface marker which is a different cell surface marker to that targeted by at least one of the other targeting complexes, wherein the desired activity of the effector system is dependent on the selective internalization and functional cooperation of the components thereof.
    Type: Grant
    Filed: December 19, 1995
    Date of Patent: December 15, 1998
    Assignee: Medical Research Council
    Inventor: Franklin Grosveld
  • Vector for integration site independent gene expression in mammalian host cells
    Patent number: 5770398
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 23, 1998
    Assignee: Medical Research Council
    Inventors: Franklin Grosveld, Dimitris Kioussis
  • Methods for obtaining production of a gene product in a host cell in vivo or in vitro using a DNA molecule for integration site independent gene expression
    Patent number: 5744456
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 28, 1998
    Assignee: Medical Research Council
    Inventors: Franklin Grosveld, Dimitris Kioussis
  • Isolated DNA molecules for integration site independent gene expression in mammalian host cells
    Patent number: 5736359
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 7, 1998
    Assignee: Medical Research Council
    Inventors: Franklin Grosveld, Dimitris Kioussis
  • Methods of obtaining a DNA sequence for integration site independent gene expression
    Patent number: 5635355
    Abstract: Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 3, 1997
    Assignee: The Medical Research Council
    Inventors: Franklin Grosveld, Dimitris Kioussis