Abstract: A tissue restoration implant adapted for use with a pre-determined tissue, and methods of making and using the same. The tissue restoration implant adapted for use with a pre-determined tissue can include a three-dimensional fiber scaffold, the scaffold comprising at least three systems of fibers; wherein two of the three fiber systems define an upper layer, a lower layer and a medial layer between the upper layer and the lower layer within the three-dimensional fiber scaffold; wherein one of the at least three fiber systems interconnects the upper layer, the lower layer and the medial layer; wherein the at least three fiber systems each comprise a bio-compatible material; and wherein the fiber scaffold, or one or more of the fiber systems, provide a characteristic that functions to restore the pre-determined tissue upon implantation. The tissue restoration implant adapted for use with a pre-determined tissue can include one or more cells that can develop into the pre-determined tissue.