Abstract: A drug carrier, and methods of making and using the same. The drug carrier includes a scaffold including a plurality of layers and a fiber system interconnecting the plurality of layers, wherein the layers define internal and superficial positions for the scaffold; and a drug releasably engaged with the scaffold according to a controlled release profile, wherein the drug is releasably engaged at at least one of the internal or superficial positions. Optionally, the scaffold is a three-dimensional fiber scaffold including at least three systems of fibers, wherein two of the three fiber systems define the plurality of layers, wherein one of the at least three fiber systems interconnects the plurality of layers, and wherein the three dimensions of the scaffold define internal and superficial positions within the scaffold. The drug carrier design is versatile, such that drug release profiles can be customized for a given application.