Abstract: An applicator that has an elastic band to snap a microneedle array against the skin with a predetermined force and velocity. The microneedle array, which may be pre-loaded with drug(s), is attached to the elastic band such that the band can be secured in place (e.g., wrapped around a person's arm), pulled away from the arm, and released from a suitable distance so that the microneedle array snaps back against the arm with sufficient force to cause the intended amount of penetration of the microneedles. Also, a microneedle application device that has an elastic band, a microneedle device, and means for attaching the band to the microneedle device.

Abstract: A method of manufacturing a moldable microneedle array (54) is described comprising providing a negative mold insert (44) characterized by a negative image of microneedle topography wherein at least one negative image of a microneedle is characterized by an aspect ratio of between about 2 to 1 and about 5 to 1. The negative mold insert (44) is used to define a structured surface of a negative mold cavity (42). Molten plastic material is injected into the heated negative mold cavity. The molten plastic material is subsequently cooled and detached from the mold insert to provide a molded microneedle array (54). One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue through the skin.

Abstract: Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.

Abstract: The present invention provides a liquid spray gun with several improved features, including (1) non-cylindrical air passageways on air horns included in an air cap portion of a body assembly that provide improved shape and uniformity for the wide elongate stream of liquid formed by the spray gun; (2) the air cap portion of the body assembly being mounted for manual rotation on a nozzle portion of the body assembly between positions defined by stops and retained at those positions by friction; and (3) the body assembly through which passes liquid sprayed by the spray gun being molded of polymeric material and being manually releasable from a metal platform portion of the spray gun through which air is fed to passageways through the body assembly to spray the liquid.

Abstract: The present invention provides a liquid spray gun with several improved features, including (1) an air cap portion of a body assembly mounted for manual rotation on a nozzle portion of the body assembly between positions defined by stops and retained at those positions by friction; (2) non-cylindrical air passageways on air horns included in the air cap portion of the body assembly that provide improved shape and uniformity for the wide elongate stream of liquid formed by the spray gun; and (3) the body assembly through which passes liquid sprayed by the spray gun being molded of polymeric material and being manually releasable from a metal platform portion of the spray gun through which air is fed to passageways through the body assembly to spray the liquid.

Abstract: The present invention provides a liquid spray gun with several improved features, including (1) a molded polymeric possibly disposable body assembly through which passes liquid sprayed by the spray gun that is manually releasable from a metal platform portion of the spray gun through which air is fed to passageways through the body assembly to spray the liquid; (2) non-cylindrical air passageways on air horns that provide improved shape and uniformity for the wide elongate stream of liquid formed by the spray gun, and (3) an air cap portion of the body assembly mounted for manual rotation on a nozzle portion of the body assembly between positions defined by stops and retained at those positions by friction.