Patents by Inventor Frans Alfons Maria Van Den Keybus

Frans Alfons Maria Van Den Keybus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS
    Publication number: 20100076187
    Abstract: The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
    Type: Application
    Filed: December 5, 2007
    Publication date: March 25, 2010
    Inventors: Gregor James MacDonald, José Ignacio Andrés-Gil, Frans Alfons Maria Van Den Keybus, José Manuel Bartolomé-Nebreda, Michiel Luc Maria Van Gool
  • TRISUBSTITUTED 1,2,4-TRIAZOLES
    Publication number: 20090253691
    Abstract: The present invention relates to 3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
    Type: Application
    Filed: April 19, 2007
    Publication date: October 8, 2009
    Applicants: JANSSEN PHARMACEUTICA N.V., BIOFOCUS DPI LIMITED
    Inventors: Johannes Wilhelmus John F. Thuring, Gregor James MacDonald, Anne Simone Josephine Lesage, Wei Zhuang, Marcel Frans Leopold De Bruyn, Frans Alfons Maria Van Den Keybus, Yves Emiel Maria Van Roosbroeck, Theodorus Dinklo
  • Piperidin-4-Yl-Pyridazin-3-Ylamine Derivatives as Fast Dissociating Dopamine 2 Receptor Antagonists
    Publication number: 20080227791
    Abstract: The present invention relates to compounds that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
    Type: Application
    Filed: October 24, 2006
    Publication date: September 18, 2008
    Applicant: Janssen Pharmaceutica N.V.
    Inventors: Marcel Frans Leopold De Bruyn, Gregor James Macdonald, Ludo Edmond Josephine Kennis, Xavier Jean Michel Langlois, Frans Alfons Maria Van Den Keybus, Yves Emiel Maria Van Roosbroeck