Patents by Inventor Frans Ejner Ravn
Frans Ejner Ravn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10921234Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field and optionally one or more sources of excitation light.Type: GrantFiled: July 3, 2019Date of Patent: February 16, 2021Assignee: CHEMOMETEC A/SInventors: Martin Glensbjerg, Johan Holm, Søren Kjærulff, Frans Ejner Ravn Hansen
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Patent number: 10697884Abstract: The present invention relates to methods and systems for image cytometry analysis, in particular using light sources to be cooled. Thereby is provided optimal light conditions for image cytometry.Type: GrantFiled: December 3, 2015Date of Patent: June 30, 2020Assignee: ChemoMetec A/SInventors: Martin Glensbjerg, Johan Holm, Søren Kjaerulff, Frans Ejner Ravn Hansen
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Patent number: 10458896Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field, dark field or one or more sources of excitation light. The system comprises illumination means (11, 112), a sample holder (100), a sample compartment (101), imaging means (120), collection means (121), light modulation means (122, 123), and detection means (130) with active detection elements (131).Type: GrantFiled: May 28, 2014Date of Patent: October 29, 2019Assignee: ChemoMetec A/SInventors: Martin Glensbjerg, Johan Holm, Søren Kjaerulff, Frans Ejner Ravn Hansen
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Publication number: 20190323944Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field and optionally one or more sources of excitation light.Type: ApplicationFiled: July 3, 2019Publication date: October 24, 2019Inventors: Martin Glensbjerg, Johan Holm, Søren Kjærulff, Frans Ejner Ravn Hansen
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Patent number: 10254223Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.Type: GrantFiled: January 25, 2018Date of Patent: April 9, 2019Assignee: ChemoMetec A/SInventors: Søren Kjaerulff, Mette Elena Skinderso, Helle Frobose Sorensen, Frans Ejner Ravn, Martin Glensbjerg
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Publication number: 20180195958Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.Type: ApplicationFiled: January 25, 2018Publication date: July 12, 2018Inventors: Søren Kjaerulff, Mette Elena Skinderso, Helle Frobose Sorensen, Frans Ejner Ravn, Martin Glensbjerg
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Patent number: 9903819Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.Type: GrantFiled: August 29, 2014Date of Patent: February 27, 2018Assignee: ChemoMetec A/SInventors: Søren Kjaerulff, Mette Elena Skinderso, Helle Frobose Sorensen, Frans Ejner Ravn, Martin Glensbjerg
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Publication number: 20170261419Abstract: The present invention relates to methods and systems for image cytometry analysis, in particular using light sources to be cooled. Thereby is provided optimal light conditions for image cytometry.Type: ApplicationFiled: December 3, 2015Publication date: September 14, 2017Inventors: Martin Glensbjerg, Johan Holm, Søren Kjaerulff, Frans Ejner Ravn Hansen
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Publication number: 20160103058Abstract: The present invention relates to methods and systems for image cytometry analysis, typically at low optical magnification, where analysis is based on detection of biological particles using UV bright field, dark field or one or more sources of excitation light. The system comprises illumination means (11, 112), a sample holder (100), a sample compartment (101), imaging means (120), collection means (121), light modulation means (122, 123), and detection means (130) with active detection elements (131).Type: ApplicationFiled: May 28, 2014Publication date: April 14, 2016Inventors: Martin Glensbjerg, Johan Holm, Søren Kjaerulff, Frans Ejner Ravn Hansen
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Patent number: 9224031Abstract: The invention relates to image analysis of dark field images obtained at low magnification below 10:1. Image analysis of dark field images obtained at low magnification can be combined with analyzes of images obtained in respect of the same section of a sample and same magnification but with other techniques such as fluorescent microscopy. The system and method can be used e.g. for particle counting, particle size measurement, particle size distribution, morphology measurement, where the particles can be cells and/or cell parts. The invention also relates to a compact dark field light source unit, a system or apparatus including a microscope which by itself is compact and comprises the mentioned dark field light source unit.Type: GrantFiled: May 18, 2011Date of Patent: December 29, 2015Assignee: ChemoMetec A/SInventors: Martin Glensbjerg, Johan Christer Holm, Frans Ejner Ravn, Søren Kjaerulff
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Publication number: 20150053872Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.Type: ApplicationFiled: August 29, 2014Publication date: February 26, 2015Inventors: Søren Kjaerulff, Mette Elena Skinderso, Helle Frobose Sorensen, Frans Ejner Ravn, Martin Glensbjerg
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Patent number: 8860938Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.Type: GrantFiled: October 21, 2009Date of Patent: October 14, 2014Assignee: ChemoMetec A/SInventors: Søren Kjærulff, Mette Elena Skindersø, Helle Frobøse Sørensen, Frans Ejner Ravn, Martin Glensbjerg
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Publication number: 20130129181Abstract: The invention relates to image analysis of dark field images obtained at low magnification below 10:1. Image analysis of dark field images obtained at low magnification can be combined with analyses of images obtained in respect of the same section of a sample and same magnification but with other techniques such as fluorescent microscopy. The system and method can be used e.g. for particle counting, particle size measurement, particle size distribution, morphology measurement, where the particles can be cells and/or cell parts. The invention also relates to a compact dark field light source unit, a system or apparatus including a microscope which by itself is compact and comprises the mentioned dark field light source unit.Type: ApplicationFiled: May 18, 2011Publication date: May 23, 2013Applicant: CHEMOMETEC A/SInventors: Martin Glensbjerg, Johan Christer Holm, Frans Ejner Ravn, Søren Kjaerulff
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Patent number: 8432550Abstract: A method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals.Type: GrantFiled: March 28, 2012Date of Patent: April 30, 2013Assignee: ChemoMetec A/SInventors: Frans Ejner Ravn Hansen, Martin Glensbjerg, Börkur Arnvidarson, Jesper Myron Jeppesen
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Patent number: 8363221Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals.Type: GrantFiled: April 3, 2008Date of Patent: January 29, 2013Assignee: Chemometec A/SInventors: Frans Ejner Ravn Hansen, Martin Glensbjerg, Borkur Arnvidarson, Jesper Myron Jeppesen
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Patent number: 8125643Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals.Type: GrantFiled: May 1, 2006Date of Patent: February 28, 2012Assignee: Chemometec A/SInventors: Frans Ejner Ravn Hansen, Martin Glensbjerg, Borkur Arnvidarson, Jesper Myron Jeppesen
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Publication number: 20120045757Abstract: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample.Type: ApplicationFiled: October 21, 2009Publication date: February 23, 2012Inventors: Søren Kjaerulff, Mette Elena Skindersø, Helle Frobøse Sørensen, Frans Ejner Ravn, Martin Glensbjerg
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Patent number: 8081312Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals.Type: GrantFiled: April 3, 2008Date of Patent: December 20, 2011Assignee: Chemometec A/SInventors: Frans Ejner Ravn Hansen, Martin Glensbjerg, Borkur Arnvidarson, Jesper Myron Jeppesen
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Patent number: 6970246Abstract: The present invention relates to an apparatus and a method for detecting the fluorescence of a sample, wherein the apparatus comprises excitation light source located on the same side of the sample as the detecting means. The apparatus may be constructed as a single-sided as well as a double-sided system, wherein the double-sided system comprises double-sided excitation system and/or double-sided detecting system. The double-sided system may also be a combination of fluorescence system and conventional microscopy. The apparatus may be used for analysis of various types of biological material, liquid as well as solid material, and various other types of material suitable being analysed through fluorescence studies.Type: GrantFiled: April 11, 2001Date of Patent: November 29, 2005Assignee: ChemoMetec A/SInventor: Frans Ejner Ravn Hansen
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Publication number: 20040061070Abstract: The present invention relates to an apparatus and a method for detecting the fluorescence of a sample, wherein the apparatus comprises excitation light source located on the same side of the sample as the detecting means. The apparatus may be constructed as a single-sided as well as a double-sided system, wherein the double-sided system comprises double-sided excitation system and/or double-sided detecting system. The double-sided system may also be a combination of fluorescence system and conventional microscopy. The apparatus may be used for analysis of various types of biological material, liquid as well as solid material, and various other types of material suitable being analysed through fluorescence studies.Type: ApplicationFiled: October 10, 2002Publication date: April 1, 2004Inventor: Frans Ejner Ravn Hansen