Patents by Inventor Frantisek Rypacek
Frantisek Rypacek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090305406Abstract: The invention relates to a novel method of cultivation of mesenchymal stem cells, wherein after aseptic separation of mononuclear cells from the marrow blood, said cells are seeded in low density into sterile plastic cultivation vessels and cultivated for approximately one to three weeks in CellGro™ Hematopoietic Stem Cell Medium, certified for the clinical use, with an addition of 10% human serum and supplements, wherein the supplements are added at least once in the course of the cultivation, without removal of hematopoietic cells and without medium exchange during the cultivation procedure, without any interference with the closed cultivation system, under the standard conditions for the cultivation of tissue cultures. For the cultivation of the mesenchymal stem cells in the closed cultivation system for the clinical use in the field of orthopaedic surgery, a simple bioreactor is proposed.Type: ApplicationFiled: January 23, 2007Publication date: December 10, 2009Inventors: Robert Pytlik, Petr Hofman, Tomas Trc, David Stehlik, Tomas Soukup, Petr Kobylka, Pavel Klener, Frantisek Rypacek, Katarina Mulinkova
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Patent number: 7419709Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.Type: GrantFiled: November 28, 2006Date of Patent: September 2, 2008Assignee: CV Therapeutics, Inc.Inventors: Frantisek Rypacek, Monika Lapcikova, Ludka Machova
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Publication number: 20080160166Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.Type: ApplicationFiled: March 17, 2008Publication date: July 3, 2008Inventors: Frantisek Rypacek, Monika Lapcikova, Ludka Machova
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Patent number: 7364768Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.Type: GrantFiled: November 28, 2006Date of Patent: April 29, 2008Assignee: CV Therapeutics, Inc.Inventors: Frantisek Rypacek, Monika Lapcikova, Ludka Machova
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Publication number: 20070071879Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.Type: ApplicationFiled: November 28, 2006Publication date: March 29, 2007Inventors: Frantisek Rypacek, Monika Lapcikova, Ludka Machova
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Publication number: 20070071926Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.Type: ApplicationFiled: November 28, 2006Publication date: March 29, 2007Inventors: Frantisek Rypacek, Monika Lapcikova, Ludka Machova
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Patent number: 7160592Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.Type: GrantFiled: February 14, 2003Date of Patent: January 9, 2007Assignee: CV Therapeutics, Inc.Inventors: Frantisek Rypacek, Monika Lapcikova, Ludka Machova
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Publication number: 20060093771Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of poly(lactide-co-caprolactone) copolymer on the bonded lactone. Biologically active agents may be disposed with the poly(lactide-co-caprolactone) copolymer layers. Such coated surfaces may be useful in medical devices, in particular stents.Type: ApplicationFiled: October 14, 2005Publication date: May 4, 2006Inventors: Frantisek Rypacek, Monika Lapcikova, Ludka Machova
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Publication number: 20030219562Abstract: Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.Type: ApplicationFiled: February 14, 2003Publication date: November 27, 2003Inventors: Frantisek Rypacek, Monika Lapcikova, Ludka Machova
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Patent number: 6590061Abstract: Functionalized homopolymers and copolymers of &agr;-amino acids of the general formula 1, wherein X is oxygen or sulphur; R1 could be alkyl, alkenyl, substituted alkyl, aryl or substituted aryl; structure [A]n represents a poly(amino acid) chain based on &agr;-amino acids or their derivatives with protected functional groups, wherein n could be in the range of 1-500; Y is either OH, or a structure of the formula 2, wherein R2 is H or an amino-acid residue, or a structure of the formula 3, wherein Z and Z′ are either NH or O; R3 is a chemical structure selected from alkyls, substituted alkyls, aryls, substituted aryls, or a polymer selected from a group comprising poly(ethylene oxide), poly(propylene oxide) and polybutadiene; P is hydrogen or an acyl group derived from a carboxylic acid selected from the group including alkanoic acids, succinic acid, maleic acid, acrylic acid, phthalic acids and cyclohexane dicarboxylic acids, or it is an acyl selected from a group consisting of compounds accorType: GrantFiled: January 29, 2001Date of Patent: July 8, 2003Assignee: Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech RepublicInventors: Frantisek Rypacek, Milan Dvorak, Dana Kubies, Ludka Machova
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Patent number: 5160745Abstract: A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.Type: GrantFiled: January 9, 1990Date of Patent: November 3, 1992Assignee: The University of Kentucky Research FoundationInventors: Patrick P. DeLuca, Frantisek Rypacek
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Patent number: 4808399Abstract: The present invention pertains to a preparation for diagnosing the transport function of the fallopian tube and to a method for making such a preparation.The diagnostic preparation for investigation of the transport function of female fallopian tube, comprises a suspension of a biocompatible, biodegradable, and, if desired, labelled particles, in a vehicle commonly used for parenteral applications wherein the particles have a spherical shape with diameters in the region 10 to 600 um, which are formed from a soft hydrophilic gel based on a polymer selected from the group comprising additionally crosslinked water-soluble nontoxic and biodegradable inert polysaccharides and physiologically inert water-soluble and biodegradable poly(amino acids), polypeptides, and their derivatives, which may contain physiologically active substances.Type: GrantFiled: December 11, 1986Date of Patent: February 28, 1989Assignee: Ceskoslovenska akademie vedInventors: Frantisek Rypacek, Jan Uher, Jaroslav Drobnik
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Patent number: 4745161Abstract: The invention pertains to copolymers activated for bonding of biologically active compounds and to a method for preparation thereof.Soluble and biodegradable copolymers activated for bonding of biologically active compounds which have their main chain formed from units of aspartic acid or glutamic acid, or both, or also from units of other amino acids, according to the general formula I ##STR1## where n is 1 or 2, m is 1 or 2, a+b+c is 100, a is 0.5 to 100, b is 0 to 99.5, c is 0 to 80; the substituent R.sup.1 is --NH--NH.sub.2, --N.tbd.N or ##STR2## where x is 2 to 6, R.sup.2 is --NH(CH.sub.2).sub.x OH where x=2 to 6; and R.sup.3 is methyl, 2-propyl, 2-methylpropyl, butyl, 2-butyl, benzyl or 4-hydroxybenzyl, and the molecular weight is 5,000 to 1,000,000.Type: GrantFiled: April 1, 1986Date of Patent: May 17, 1988Assignee: Ceskoslovenska akademie vedInventors: Vladimir Saudek, Frantisek Rypacek, Jaroslav Drobnik
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Patent number: 4741872Abstract: A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.Type: GrantFiled: May 16, 1986Date of Patent: May 3, 1988Assignee: The University of Kentucky Research FoundationInventors: Patrick P. De Luca, Frantisek Rypacek
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Patent number: 4659849Abstract: A macromolecular compound with antitumor activity in which hydroxy groups in side chains of a polymer have the character of primary, secondary or tertiary alcohols and are completely or in part esterified with carboxyl in the position C4 of 1,2,4-tricarboxybenzene, whereas the carboxyls in positions C1 and C2 bind an atom of platinum with coordination bonded amino ligands.A method for producing the macromolecular compound consists in acylation of the polymer carrying alcohol groups with chloride anhydride of trimellitic acid of the formula II, ##STR1## hydrolyzing the anhydride in the subsequent step, and bonding an atom of bivalent platinum carrying an amino ligand to the formed vicinal carboxylic groups.Type: GrantFiled: November 8, 1985Date of Patent: April 21, 1987Assignee: Ceskoslovenska akademie vedInventors: Jaroslav Drobnik, Dagmar Noskova, Frantisek Rypacek, Marie Metalova, Vladimir Saudek