Patents by Inventor Frantisek Svec

Frantisek Svec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4923610
    Abstract: An object of the invention are macroporous polymeric membranes, suitable above all for the separation of polymers, which consists of the copolymer of a monovinyl monomer, selected from the group comprising acrylates, methacrylates, vinylpyridine, N-vinylpyrrolidone, vinyl acetate, and hydroxystyrene, with a divinyl monomer, selected from the group comprising alkylene and hydroxyalkylene diacrylates and dimethacrylates, divinylbenzene, and divinylpyridine, at the ratio of monomers of both types ranging from 5:95 to 95:5 wt. %. The membranes are formed from polymeric globular entities which have the size 0.05 to 0.5 .mu.m and are interconnected by covalent bonds, whereas communicating voids--pores occur between the globuli.The total thickness of membranes is 0.2 to 15 mm. and their specific surface area, which is measurable also in the dry state, may attain 400 m.sup.2 /g. Glycidyl methacrylate is advantageously used as the monovinyl monomer in the amount 5-80 vol. % related to the total volume of monomers.
    Type: Grant
    Filed: September 25, 1989
    Date of Patent: May 8, 1990
    Assignee: Ceskoslovenska akademive ved and Akademia Nauk SSSR
    Inventors: Frantisek Svec, Boris G. Belenkii
  • Patent number: 4889632
    Abstract: An object of the invention are macroporous polymeric membranes, suitable above all for the separation of polymers, which consist of the copolymer of a monovinyl monomer, selected from the group comprising acrylates, methacrylates, vinylpyridine, N-vinylpyrrolidone, vinyl acetate, and hydroxystyrene, with a divinyl monomer, selected from the group comprising alkylene and hydroxyalkylene diacrylates and dimethacrylates, divinylbenzene, and divinylpyridine, at the ratio of monomers of both types ranging from 5:95 to 95:5 wt.%. The membranes are formed from polymeric globular entities which have the size 0.05 to 0.05 .mu.m and are interconnected by covalent bonds, whereas communicating voids - pores occur between the globuli. The total thickness of membranes is 0.2 to 15 mm and their specific surface area, which is measurable also in the dry state, may attain 400 m.sup.2 /g. Glycidyl methacrylate is advantageously used as the monovinyl monomer in the amount 5-80 vol.% related to the total volume of monomers.
    Type: Grant
    Filed: December 7, 1988
    Date of Patent: December 26, 1989
    Assignee: Ceskoslovenska Akademie ved
    Inventors: Frantisek Svec, Miroslav Bleha, Tatiana B. Tennikova, Boris G. Belenkii
  • Patent number: 4794177
    Abstract: The invention pertains to a method for the production of bead dextran materials for gel chromatography.The subject of the invention is a method for the production of bead dextran materials for gel chromatography, wherein dextran is, before or during the suspension process or in both stages, subjected to reduction in an alkaline solution, advantageously by the action of sodium borohydride, whereas the density of crosslinking is controlled above all by variation of the concentration of the initial dextran solution and the resulting gel may be optionally subjected to the additional crosslinking in a separate subsequent operation.The procedure according to the invention provides the product of higher quality with a lower content of carboxylic groups and substantially facilitates the preparation of gels with a very high and a very low crosslink density.
    Type: Grant
    Filed: December 16, 1985
    Date of Patent: December 27, 1988
    Assignee: Ceskoslovenska akademie ved
    Inventors: Jan Peska, Jiri Lenfeld, Zedenek Plichta, Milan Benes, Frantisek Svec, Jiri Coupek
  • Patent number: 4622367
    Abstract: The invention pertains to X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates and to a method of their preparation.The subject of this invention are X-ray contrast spherical hydrogel particles based on polymers and copolymers of acrylates and methacrylates characterized by the particles of spherical form with diameter 0.2 to 2 mm, which strongly swell in water and contain a derivative of amino-triiodobenzoic acid of general formula I, ##STR1## where R.sup.1,R.sup.2 is hydrogen, acyl group with 1 to 3 carbon atoms or alkyl with 1 to 10 carbon atoms and X is halogen, --OH or --NH(CH.sub.2).sub.n NH.sub.2, where n=1-6, covalently bonded to the polymer skeleton.
    Type: Grant
    Filed: December 10, 1985
    Date of Patent: November 11, 1986
    Assignee: Ceskoslovenska akademie ved
    Inventors: Daniel Horak, Marie Metalova, Frantisek Svec, Jaroslav Drobnik, Jaroslav Kalal, Michail I. Kuzin, Arnold A. Adamian, Jurij V. Moiseiev, Klara Z. Gumargalieva
  • Patent number: 4415700
    Abstract: Hydrophilic latex particles consisting of a homo- or co-polymer of monomers which are sparingly soluble in water, which hydrophilic latex particles can be prepared by emulsion polymerization in the presence of a water-soluble, radical-forming initiator but without an addition of an emulsifier, stabilizer or wetting agent. A process for the preparation of these hydrophilic latex particles, wherein a monomer which is sparingly soluble in water or several monomers which are sparingly soluble in water are dispersed in water and, with the exclusion of oxygen, for example in an inert atmosphere, are homo- or co-polymerized by emulsion polymerization in the presence of a water-soluble, radical-forming initiator but without any addition of an emulsifier, stabilizer or wetting agent.A diagnostic agent containing these hydrophilic latex particles as carrier and biologically and/or immunologically active substances covalently bound to this carrier either directly or via a coupling agent as a bridge.
    Type: Grant
    Filed: December 16, 1981
    Date of Patent: November 15, 1983
    Assignees: Boehringer Mannheim GmbH, Tschechoslowakische Academie der Wissenschaften
    Inventors: Hans-Georg Batz, Paul Tanswell, Manfred Baier, Karel Bouchal, Jaroslav Kalal, Frantisek Svec, Eva Zurkova
  • Patent number: 4340483
    Abstract: The invention relates to the polar polymeric sorbent applicable in gas and liquid chromatography, which is based on glycidyl esters. The sorbent is formed by the macroporous copolymer containing 3-70% of polymerized monomeric units with epoxy groups, e.g. glycidyl methacrylate or glycidyl acrylate units, and 97-30% of a crosslinking agent, e.g. alkylene dimethacrylate, alkylene diacrylate, hydroxyalkylene dimethacrylate, hydroxyalkylene diacrylate (alkylene containing 1-6 C atoms), or divinylbenzene. The sorbent may further contain up to 30% of polymerized monomeric units containing nitrile groups, e.g. acrylonitrile and methacrylonitrile units. The polarity of sorbent can be further modified, according to the invention, by the reaction with various nucleophilic agents, e.g. water, alcohols, carboxylic acids and their derivatives, ammonia, amines, thioalcohols, acrylonitrile.
    Type: Grant
    Filed: December 23, 1977
    Date of Patent: July 20, 1982
    Assignee: Ceskoslovenska akademie ved
    Inventors: Jaromir Lukas, Jaroslav Kalal, Frantisek Svec
  • Patent number: 4269962
    Abstract: The invention relates to a negative electron resist for application in electron lithography. It consists of an organic copolymer formed by copolymerization of butadiene or isoprene with glycidyl acrylate or glycidyl methacrylate. The resist exhibits the high sensitivity to irradiation by electrons and, at the same time, a good adhesion to the base and a resistance towards common etching agents. The copolymer is advantageously prepared by radical polymerization and a high purity of the product does not require further purification. The electron resist manufactured in this way has the long-term workability.
    Type: Grant
    Filed: October 27, 1978
    Date of Patent: May 26, 1981
    Assignee: Ceskoslovenska akademie ved
    Inventors: Jaroslav Kalal, Bohumil Bednar, Jaromir Zachoval, Jiri Petr, Zdenek Pelcbauer, Frantisek Svec
  • Patent number: 4245064
    Abstract: The invention relates to a solid insoluble carrier which is activated for bonding of nucleophilic groups and to a method of its preparation. The carrier contains active groups --O.CO.O.R, where R is the residue selected from the group comprising nitrophenyl, dinitrophenyl, trichlorophenyl, pentachlorophenyl, N-succinimidyl, N-phthalimidyl, and 8-quinolinyl. Active groups are bonded to polysaccharides, phenol-formaldehyde resins, polyacrylates, or polyacrylamides. The invention further relates to a method for preparation of the polymeric carrier, which consists in treatment of polymers carrying hydroxyl functions and selected from the group comprising polysaccharides, phenol-formaldehyde resins, polyacrylates, and polyacrylamides, with esters of chloroformic acid which contain the above mentioned active groups.
    Type: Grant
    Filed: February 12, 1979
    Date of Patent: January 13, 1981
    Assignee: Ceskoslovenska akademie ved
    Inventors: Jaroslav Drobnik, Jaroslav Kalal, Jiri Labsky, Vladimir Saudek, Frantisek Svec
  • Patent number: 4093602
    Abstract: Three-dimensional polymeric material in the form of spherical particles of diameter .ltoreq.3 mm and containing up to 40% of free aldehyde groups which exhibits a measurable specific surface area is prepared by copolymerization of an aldehyde monomer R.sub.1 CH.dbd.C(CH.dbd.O)R.sub.2, where R.sub.1 is H, C.sub.1-5 alkyl, aryl or furyl and R.sub.2 is H, C.sub.1-5 alkyl, halogen, CN, phenyl or furyl, with a crosslinking agent in the aqueous dispersion phase. The dispersion contains 1 - 25% of a component reducing the monomer solubility in water, which is either an inorganic salt of alkali metal or alkaline earth metal or a water-soluble alcohol. The crosslinking agent used as comonomer is divinylbenzene, diester CH.sub.2 .dbd.C(R.sub.1)COOR.sub.2 OCOC(R.sub.1).dbd.CH.sub.2 (R.sub.1 .dbd. H, C.sub.1-10 alkyl or halogen; R.sub.2 .dbd. C.sub.1-10 alkylene or hydroxyalkylene), or diamide CH.sub.2 .dbd.C(R.sub.1)CONHR.sub.2 NHCOC(R.sub.1).dbd.CH.sub.2 (R.sub.1 .dbd. H, C.sub.1-10 alkyl or halogen; R.sub.2 .dbd. C.
    Type: Grant
    Filed: October 20, 1975
    Date of Patent: June 6, 1978
    Assignee: Ceskoslovanska akademie ved
    Inventors: Jaroslav Kalal, Eva Zurkova, Frantisek Svec
  • Patent number: 4089823
    Abstract: The invention relates to polymeric materials containing variable amounts of aldehyde groups and comprising the chain units ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are H, C.sub.1 - C.sub.5 alkyl, aryl, furyl, halogen, nitrile group or hydroxyl and R.sup.4 is C.sub.1 - C.sub.20 alkylene, arylene, --COO(CH.sub.2).sub.n --, --O--(CH.sub.2).sub.n --, --COO(CH.sub.2).sub.n CH(OH)CH.sub.2 OCO(CH.sub.2).sub.m -- or --(CH.sub.2).sub.n OCOR.sup.5 COO(CH.sub.2).sub.m -- (n and m are integers 0 - 20 and R.sup.5 is the single bond, C.sub.1 - C.sub.20 alkylene or hydroxyalkylene or arylene). The material may be in the form of globules with a measurable specific surface area and is suitable for bonding of biologically active compounds containing primary amino groups or other amines to produce polymeric chelating agents. The invention further relates to the method for preparation the above materials which consists in treatment of the polymeric materials comprising units of the general formula ##STR2## where R.sup.1, R.
    Type: Grant
    Filed: April 21, 1976
    Date of Patent: May 16, 1978
    Assignee: Ceskoslovenska akademie ved
    Inventors: Jaroslav Kalal, Frantisek Svec
  • Patent number: 4031037
    Abstract: Organic three-dimensional polymeric gel-like materials containing covalently bonded phosphoric acid or a derivative thereof and a method for their manufacture. The bonding is accomplished by the reaction of the free hydroxy or epoxide groups in the homogeneous or macroporous gel-like matrix with the H.sub.3 PO.sub.4, P.sub.2 O.sub.5, phosphorus pentahalide and oxyhalide. The halide containing groups may then be hydrolyzed to form acid groups which then may be modified to form complex compounds by reaction with Lewis acids. The gel material may serve as a strongly acidic cation exchanger, catalyst or polymer reagent.
    Type: Grant
    Filed: February 20, 1975
    Date of Patent: June 21, 1977
    Inventors: Jaroslav Kalal, Jiri Coupek, Svatopluk Pokorny, Frantisek Svec, Karel Bouchal