Abstract: The present invention relates to solid pharmaceutical compositions comprising N-[1-(5-cyano-pyridin-2?ylmethyl)-1H-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide or pharmaceutically acceptable salt thereof. The invention further relates to methods for manufacturing said compositions and their uses for the treatment or prevention of diseases and disorders linked to T-type calcium channels such as epilepsy.

Abstract: The present invention relates to dispersible tablets comprising the compound (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-I, I-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceuti-cally acceptable salt thereof.

Abstract: In a method for preparing at least partially dried granules, an API, a base powder, and a granulation liquid are fed to a granulator. The API, the base powder and the granulation liquid are mixed within the granulator to produce an API/base powder/granulation liquid mixture. This liquid mixture within the granulator is heated to a heating temperature (TH) that exceeds an evaporation temperature (TE) of the granulation liquid contained in an API/base powder/granulation liquid mixture to allow at least a part of the granulation liquid contained in the API/base powder/granulation liquid mixture to evaporate in order to obtain at least partially dried granules containing at least the API and the base powder. The at least partially dried granules are discharged from the granulator.

Abstract: The present invention relates to dispersible tablets compris-ing the compound (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-l, l-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceuti-cally acceptable salt thereof.

Abstract: The present invention relates to dispersible tablets comprising the compound (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a multilayer pharmaceutical composition that can be dispersed in water, containing one antimalarial agent in combination with at least one other antimalarial agent. The present invention also relates to a method for producing such a pharmaceutical composition.