Patents by Inventor Franz Dietrich Klingler

Franz Dietrich Klingler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for manufacturing of chiral lobelin
    Patent number: 7511147
    Abstract: The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: March 31, 2009
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Franz-Dietrich Klingler, Rainer Sobotta
  • Process for preparing (R)-salbutamol
    Patent number: 7247750
    Abstract: Disclosed are processes for preparing levosalbutamol or the pharmacologically acceptable salts thereof on an industrial scale, using asymmetric hydrogenation as the key step and optionally a special sequence of subsequent steps, using rhodium as catalyst and a chiral bidentate phosphine ligand such as (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as catalyst system.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: July 24, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Paul Kreye, Alfons Lenhart, Franz Dietrich Klingler
  • Process for preparing (R)-salbutamol
    Patent number: 7049469
    Abstract: The present invention relates to an improved process for preparing levosalbutamol or the pharmacologically acceptable salts thereof on an industrial scale, using asymmetric hydrogenation as the key step and optionally a special sequence of subsequent steps, using rhodium as catalyst and a chiral bidentate phosphine ligand such as (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as catalyst system.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: May 23, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Paul Kreye, Alfons Lenhart, Franz Dietrich Klingler
  • Enantioselective hydrogenation of intermediates in the synthesis of tipranavir
    Patent number: 7002017
    Abstract: The invention relates to a process for preparing the compounds of general formula I by enantioselective hydrogenation of the compounds of formula II in the presence of special hydrogenation catalysts. The invention is characterised by high enantioselectivity, providing easy access to a category of important pharmaceutical compositions, i.e. intermediates for the synthesis of tipranavir.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: February 21, 2006
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Franz Dietrich Klingler, Michael Steigerwald, Richard Ehlenz
  • Process for manufacturing of chiral lobelin
    Publication number: 20060014791
    Abstract: The present invention relates to a shortened process for preparing L-lobeline by rhodium-catalysed asymmetric hydrogenation on an industrial scale.
    Type: Application
    Filed: July 8, 2005
    Publication date: January 19, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Franz-Dietrich Klingler, Rainer Sobotta
  • Enantioselective hydrogenation of intermediates in the synthesis of tipranavir
    Publication number: 20040224990
    Abstract: The invention relates to a process for preparing the compounds of general formula I 1
    Type: Application
    Filed: March 10, 2004
    Publication date: November 11, 2004
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Franz Dietrich Klingler, Michael Steigerwald, Richard Ehlenz
  • Process for preparing beta-L-2'deoxy-thymidine
    Publication number: 20030236397
    Abstract: The present invention relates to a new, essentially four-step process for preparing beta-L-2′-deoxy-thymidine starting from L-arabinose. The process according to the invention is particularly important for mass production of beta-L-2′-deoxy-thymidine.
    Type: Application
    Filed: April 14, 2003
    Publication date: December 25, 2003
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Franz Dietrich Klingler, Paul Kreye, Wolfgang Baumgarten
  • Process for preparing adrenaline
    Patent number: 6218575
    Abstract: An improved process for preparing adrenaline, or an addition salt thereof, on an industrial scale, with asymmetric hydrogenation as a key step and a special sequence of successive steps, using [Rh(COD)Cl]2 as catalyst and a chiral, bidentate phosphine ligand such as (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphinomethyl)-N-methylaminocarbonylpyrrolidine as the catalyst system.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: April 17, 2001
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Franz Dietrich Klingler, Lienhard Wolter