Abstract: A process is disclosed for optimizing process flows in a facility, for example, a refinery, having stores, for example an oil tank, with a minimum and maximum fill level. Different raw materials, such as different types/grades of crude oil, are supplied sequentially in a predetermined quantity of batches at predetermined time periods and transported to the stores. The batches are then processed in at least one processing facility, such as a crude oil distillation plant, into primary products which are stored in additional stores and are optionally available for processing in another production stage or for delivery. The optimal sequence for supplying and processing the batches in the predetermined time period is determined by sequentially optimizing the rank order of each batch so as to minimize or eliminate the sum of infeasibilities, such as overfill and underfill time intervals, for the stores and the additional stores.