Abstract: In accordance with the invention an immersion bath roll is suggested for an immersion bath with liquid metal with a roll body (2), extending along a longitudinal axis (A), as well as essentially cylindrical bearing journals (3) for the cooperation with bearing sleeves for the mounting of the immersion bath roll (1, 1a, 1b), wherein each bearing journal (3) possesses at least one groove (4), which extends in the circumferential over the total circumference of the bearing journal (3), and which is filled with a protective layer (41) produced by thermal spraying.

Abstract: The present invention relates to unsaturated polyester resin or vinyl ester resin compositions that are essentially free of cobalt; that are curable with a peroxide component; and that, comprise a polymer containing reactive unsaturations, optionally a reactive diluent, and a dioxo component; which dioxo component consists of one or more dioxo-compounds having a calculated reduction energy (CRE), being the energy difference in kcal/mole between the lowest energy conformations of the radical anion and the corresponding neutral molecule as calculated by means of the Turbomole Version 5 program, in the range of from ?5 to ?30 kcal/mole. These resin compositions show a reduced gel-time drift tendency. The present invention further also relates to objects and structural parts prepared from such unsaturated polyester or vinyl ester resin compositions by curing with a peroxide. The present invention finally also relates to methods of peroxide curing of unsaturated polyester resin or vinyl ester resin compositions.

Abstract: A method of producing a titanium-suboxide-based coating material comprises the following steps: providing a titanium-suboxide base material; and treating the titanium-suboxide base material under oxidizing conditions for in-situ development of a finely dispersed titanium-dioxide component in the ceramic titanium-suboxide base material.

Abstract: With the method for manufacturing a thermally sprayed layer (2) on a substrate (1), in particular a ceramic coating is applied to a metallic body. The sprayed layer is applied to a structured surface (3, 10) of the substrate. The surface structure (3) of the substrate is produced by material removal by means of a high pressure liquid jet (4). A removal point (40) is thereby controlledly moved on the substrate while producing a macro-topography, namely by moving the liquid jet and/or the substrate. A groove-like removal track (41) is produced by the material removal which can be in a straight line or curved and which has a micro-topography. A macro-profile (3′) of the macro-topography is manufactured by placing a plurality of removal tracks next to one another and by partial overlapping of these removal tracks.

Abstract: A powder of dicalcium silicate is made by spray drying calcia and silica with incorporation of sodium and phosphorus or stabilized zirconia. The spray dried powder is sintered to form a thermal spray powder. Sprayed coatings have a web of interconnected, randomly oriented microcracks substantially perpendicular to the coating surface. The coatings are stable in thermal cycling and a hot corrosive environment.

Abstract: The invention concerns retrovirus envelope glycoprotein mutants characterized in that they are glycoproteins capable of specifically binding with chemokine receptors and having an inhibiting activity with respect to a retroviral infection.

Abstract: The use of a thermal spray method relates to the production of a layer (20) for a heat insulating coat of a material (10) in powder form. This material consists at least to 80 mol % of zirconium silicate ZrSiO4, in particular of the mineral zircon, and the majority of its powder particles (1) have diameters in the region between 10 and 100 &mgr;m. During the spraying on the particles are at least partially melted through in a gas flow (42) under reducing conditions and at a temperature greater than 20000° C. Method parameters, among others the dwell time of the particles in a heat imparting medium, in particular a plasma (41) or a flame, the temperature of the heat imparting medium and the momentum transferred to the particles, are chosen in such a manner that the layer (20) which is formed of the particles has a structure with lamellar elements (21).

Abstract: The method for the production of a ceramic layer on a metallic base material combines the following measures: The base material is preheated. Ceramic coating material is applied to a locally melted surface region of the base material. The coating material is therein likewise melted. A metallurgical bonding zone is provided using an additive material which reacts with the coating material and which is additionally applied to the base material as an adhesion producing layer or is added to the base material as a component of the alloy.

Abstract: A powder of dicalcium silicate is made by spray drying calcia and silica with incorporation of sodium and phosphorus or stabilized zirconia. The spray dried powder is sintered to form a thermal spray powder. Sprayed coatings have a web of interconnected, randomly oriented microcracks substantially perpendicular to the coating surface. The coatings are stable in thermal cycling and a hot corrosive environment.

Abstract: A process is provided for preparing a fatty acyl isethionate salt of the formula R1C(O)OR2SO3M which comprises reacting at least one fatty acid of the formula R1C(O)OH with at least one hydroxyalkanesulfonic acid salt of the formula HOR2SO3M in the presence of a catalyst, and distilling off water, wherein R1 is a linear or branched, saturated or unsaturated hydrocarbon having 5 to 31 carbon atoms, R2 is a linear, saturated or unsaturated hydrocarbon having 2 to 4 carbon atoms, and M is lithium, sodium, potassium, or ammonium and is characterised in that a foam control agent comprising a silicone oil is added. The foam control agent is added preferably once the reaction mixture is homogeneous. The process is suitably carried out with substantially equimolar amounts of fatty acid and hydroxyalkanesulfonic acid salt, preferably without distilling off any fatty acid.

Abstract: Prolonged-action immunotoxin consisting of a conjugate in which an antibody or antibody fragment is coupled, by means of a covalent structure containing a disulfide group or a thioether group, with a glycoprotein which inactivates ribosomes and has a prolonged action obtained by the oxidation of its saccharide units which periodate ions.

Abstract: The present invention relates to conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule chosen from antibodies, fragments of antibodies, proteins such as peptide hormones or human proteins, and peptide ligands. It also relates to the activated inophores.These conjugates are suitable as immunotoxin potentiators.

Abstract: Immunotoxins formed by the covalent coupling of, on the one hand, the A chain of ricin, as such or correctly modified, with, on the other hand, an antibody or a fragment of an antibody, used in its natural form or correctly modified, which possesses the capacity to selectively recognize an antigen carried by the intended target cells. The coupling is effected either via a disulfide bond or via a thioether bond, with the limitation that, when the coupling is effected via a disulfide and one of the sulfur atoms is that belonging to the A chain of ricin, the other sulfur is bonded to the antibody by a spacing structure which is itself bonded to a group of the protein other than an amine group.

Abstract: The present invention relates to conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule chosen from antibodies, fragments of antibodies, proteins such as peptide hormones or human proteins, and peptide ligands. It also relates to the activated ionophores.These conjugates are suitable as immunotoxin potentiators.

Abstract: The present invention relates to a process for potentiating the activity of a conjugate consisting of the A chain of ricin coupled with an antibody directed against human T cells, the said process consisting in adding an effective quality of ammonium chloride to the said conjugate.

Abstract: The present invention relates to conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule chosen from antibodies, fragments of antibodies, and peptide ligands. It also relates to the activated ionophores.These conjugates are suitable as immunotoxin potentiators.

Abstract: The invention relates to a cytotoxic pharmaceutical combination comprising:at least a first antibody possessing the capacity of selective recognition of a target antigen or antigens carried by cells to be destroyed, the said antibody being characteristic of an animal species different from that of the target cells,at least one cytotoxic conjugate obtained by covalent bond coupling of the A chain of ricin with a second antibody specific for immunoglobins of the animal species to which the said first antibody or antibodies belong.

Abstract: The present invention relates to drugs characterized in that they comprise, in association, at least one immunotoxin and at least one monovalent carboxylic ionophore.

Abstract: The present invention relates to new immunoenzymic conjugates resulting from a chemical coupling, by covalent bond, of an antibody or a fragment of antibody, which has retained the capacity of recognizing the selected antigen, with an enzyme capable of producing ammonium ions from natural substrates which are well tolerated in higher animal organisms.The invention also relates to a process for the preparation of these conjugates and the medicinal associations of said conjugates with an immunotoxin.

Abstract: Imidazolides of the formula: ##STR1## in which: E represents an inert spacing structure; andG represents a group: ##STR2## or a group --S--S--X, in which X is an activating group. Application: synthesis of cytotoxic conjugates.