Abstract: The present invention relates to a method ex vivo for classifying a patient in need as non-responder or responder to immune checkpoint inhibitor therapy, and the use of a gene set for classifying a patient in need as non-responder or responder to immune checkpoint inhibitor therapy.

Abstract: Systems and methods are provided for generating an accounting document. In one implementation, a computer-implemented method is provided. A message is received that includes operational data. An accounting notification is generated that includes the operational data using a first business object. The accounting notification is processed and the accounting document is generated using a second business object. The accounting document includes a number of posting lines corresponding to the operational data. The accounting document is processed and a set of third business objects is assigned to each posting line. The set of third business objects includes at least one general ledger account business object and a plurality of sub-ledger account business objects. One or more data processing tasks are delegated to the one of the third business objects that are assigned to the given posting line.

Abstract: A superposition gear unit for a steering system of a motor vehicle. The gear unit comprising a drive input shaft (1) and a drive output shaft (2) which each carry gearwheels (3, 4; 3?, 4?) at their ends facing toward one another such that rotational movement of the input shaft (1) can be transmitted by the gearwheel (3; 3?), on the drive input side, to the gearwheel (4; 4?), on the drive output side, via external planetary gears (5a-5c; 5a?-5c?) which are mounted on a planetary gear carrier (6). The rotational movement of the input shaft (1) can be overlaid with additional rotation movement by intentional rotation of the planetary carrier (6) relative to the input shaft (1). The input-side gearwheel (3; 3?) and the output-side gearwheel (4; 4?) are, in each case, made as conical involute gearwheels.

Abstract: Systems and methods are provided for generating an accounting document. In one implementation, a computer-implemented method is provided. A message is received that includes operational data. An accounting notification is generated that includes the operational data using a first business object. The accounting notification is processed and the accounting document is generated using a second business object. The accounting document includes a number of posting lines corresponding to the operational data. The accounting document is processed and a set of third business objects is assigned to each posting line. The set of third business objects includes at least one general ledger account business object and a plurality of sub-ledger account business objects. One or more data processing tasks are delegated to the one of the third business objects that are assigned to the given posting line.

Abstract: An articulated element of a track comprising two parallel faces consisting of two superimposed parts with holes for articulation bolts. The contact sides of the articulation parts have teeth which mesh with one another and move parallel to the pivoting plane. To lengthen the articulation element, the teeth move transversely and are undercut in such a way that under the effect of a tractional force they bring together the parts of the faces of the articulation elements. To facilitate the manufacture of this articulation element and to reduce its cost, the flanks (9,10) of the teeth (5) and the toothspaces (1) are straight over the whole of their length and end freely on their longitudinal side (7 and 8).