Patents by Inventor Franz-Josef Mais

Franz-Josef Mais has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230203013
    Abstract: The present invention relates to a method for preparing 2-chloro-N-(1-cyanocyclopropyl)-5-[2?-methyl-5?-(pentafluoroethyl)-4?-(trifluoromethyl)-2?H-1,3?-bipyrazol-4-yl]benzamide, i.e. the compound of the formula (I) and to a method for purifying the compound of the formula I. The present invention additionally relates to new crystal forms of the compound of the formula I.
    Type: Application
    Filed: May 26, 2021
    Publication date: June 29, 2023
    Inventors: Franz-Josef MAIS, Werner LINDNER, Britta OLENIK, Birgit KEIL, Hildegard SCHEITHAUER
  • Publication number: 20220073515
    Abstract: This present invention relates to forms of methyl {4.6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3.4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I. Modification II. mono-DMSO solvate. sesqui-DMSO solvate and ¼-ethyl acetate solvate.
    Type: Application
    Filed: November 15, 2021
    Publication date: March 10, 2022
    Applicant: Adverio Pharma GmbH
    Inventors: Birgit KEIL, Franz-Josef MAIS, Winfried JOENTGEN, Alfons GRUNENBERG
  • Patent number: 11203593
    Abstract: This present invention relates to forms of methyl {4.6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3.4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I. Modification II. mono-DMSO solvate. sesqui-DMSO solvate and ¼-ethyl acetate solvate.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: December 21, 2021
    Assignee: Adverio Pharma GmbH
    Inventors: Birgit Keil, Franz-Josef Mais, Winfried Joentgen, Alfons Grunenberg
  • Publication number: 20200239469
    Abstract: This present invention relates to forms of methyl {4.6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3.4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I. Modification II. mono-DMSO solvate. sesqui-DMSO solvate and ¼-ethyl acetate solvate.
    Type: Application
    Filed: April 14, 2020
    Publication date: July 30, 2020
    Applicant: Adverio Pharma GmbH
    Inventors: Birgit KEIL, Franz-Josef MAIS, Winfried JOENTGEN, Alfons GRUNENBERG
  • Patent number: 10662188
    Abstract: This present invention relates to forms of methyl {4.6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3.4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I. Modification II. mono-DMSO solvate. sesqui-DMSO solvate and ¼-ethyl acetate solvate.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: May 26, 2020
    Assignee: ADVERIO PHARMA GmbH
    Inventors: Birgit Keil, Franz-Josef Mais, Winfried Joentgen, Alfons Grunenberg
  • Patent number: 10570130
    Abstract: The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: February 25, 2020
    Assignee: Adverio Pharma GmbH
    Inventors: Franz-Josef Mais, Joachim Rehse, Winfried Joentgen, Konrad Siegel
  • Patent number: 10494372
    Abstract: The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride. The present invention also relates to copanlisib dihydrochloride hydrates as compounds.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: December 3, 2019
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Jan-Georg Peters, Philipp Rubenbauer, Daniel Götz, Danja Großbach, Franz-Josef Mais, Heiko Schirmer, Juergen Stiehl, Kai Lovis, Andreas Lender, Martin Seyfried, Theodor Zweifel, Maurus Marty, Günter Weingärtner
  • Publication number: 20190284186
    Abstract: The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
    Type: Application
    Filed: June 6, 2019
    Publication date: September 19, 2019
    Applicant: ADVERIO PHARMA GmbH
    Inventors: Franz-Josef MAIS, Joachim Rehse, Winfried Joentgen, Konrad Siegel
  • Patent number: 10351562
    Abstract: The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: July 16, 2019
    Assignee: Adverio Pharma GmbH
    Inventors: Franz-Josef Mais, Joachim Rehse, Winfried Joentgen, Konrad Siegel
  • Publication number: 20180370970
    Abstract: This present invention relates to forms of methyl {4.6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3.4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I. Modification II. mono-DMSO solvate. sesqui-DMSO solvate and 1/4-ethyl acetate solvate.
    Type: Application
    Filed: August 31, 2018
    Publication date: December 27, 2018
    Applicant: Adverio Pharma GmbH
    Inventors: Birgit KEIL, Franz-Josef MAIS, Winfried JOENTGEN, Alfons GRUNENBERG
  • Publication number: 20180282337
    Abstract: The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride. The present invention also relates to copanlisib dihydrochloride hydrates as compounds.
    Type: Application
    Filed: November 5, 2015
    Publication date: October 4, 2018
    Applicants: Bayer Pharma Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Jan-Georg PETERS, Philipp RUBENBAUER, Daniel GÖTZ, Danja GROßBACH, Franz-Josef MAIS, Heiko SCHIRMER, Juergen STIEHL, Kai LOVIS, Andreas LENDER, Martin SEYFRIED, Theodor ZWEIFEL, Maurus MARTY, Günter WEINGÄRTNER
  • Publication number: 20180282329
    Abstract: The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3 -yl]pyrimidin-5 -yl methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3 -yl]pyrimidin-5 -yl methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
    Type: Application
    Filed: June 5, 2018
    Publication date: October 4, 2018
    Applicant: Adverio Pharma GmbH
    Inventors: Franz-Josef MAIS, Joachim REHSE, Winfried JOENTGEN, Konrad SIEGEL
  • Patent number: 10087183
    Abstract: This present invention relates to forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I, Modification II, mono-DMSO solvate, sesqui-DMSO solvate and ¼-ethyl acetate solvate.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: October 2, 2018
    Assignee: Adverio Pharma GmbH
    Inventors: Birgit Keil, Franz-Josef Mais, Winfried Joentgen, Alfons Grunenberg
  • Patent number: 10030014
    Abstract: The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: July 24, 2018
    Assignee: ADVERIO PHARMA GMBH
    Inventors: Franz-Josef Mais, Joachim Rehse, Winfried Joentgen, Konrad Siegel
  • Publication number: 20180155336
    Abstract: The present application relates to a novel and improved process for preparing the compound 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-L-alanyl L-alaninate monohydrochloride of the formula (I) to novel precursors for its preparation, and to the preparation and use of crystal modification I of 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulphanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}-ethyl-L-alanyl L-alaninate monohydrochloride of the formula (I).
    Type: Application
    Filed: May 2, 2016
    Publication date: June 7, 2018
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Franz-Josef MAIS, Werner HEILMAN, Britta OLENIK, Birgit KEIL, Guido BECKER, Daniel MEIBOM, Thomas KUHLMANN
  • Publication number: 20170334910
    Abstract: This present invention relates to forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I, Modification II, mono-DMSO solvate, sesqui-DMSO solvate and ¼-ethyl acetate solvate.
    Type: Application
    Filed: August 9, 2017
    Publication date: November 23, 2017
    Applicant: Adverio Pharma GmbH
    Inventors: Birgit KEIL, Franz-Josef MAIS, Winfried JOENTGEN, Alfons GRUNENBERG
  • Patent number: 9388177
    Abstract: The present invention relates to methods of preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as to intermediate compounds useful in the preparation of said compounds.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: July 12, 2016
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Volker Schulze, Franz-Josef Mais
  • Publication number: 20150376184
    Abstract: This present invention relates to forms of methyl {4.6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3.4-b]pyridino-3-yl]pyrimidino-5-yl}methylcarbamate comprising its Modification I. Modification II. mono-DMSO solvate. sesqui-DMSO solvate and ¼-ethyl acetate solvate.
    Type: Application
    Filed: February 18, 2014
    Publication date: December 31, 2015
    Applicant: Adverio Pharma GmbH
    Inventors: Birgit KEIL, Franz-Josef MAIS, Winfried JOENTGEN, Alfons GRUNENBERG
  • Publication number: 20150148542
    Abstract: The present invention relates to methods of preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as to intermediate compounds useful in the preparation of said compounds.
    Type: Application
    Filed: July 3, 2013
    Publication date: May 28, 2015
    Inventors: Volker Schulze, Franz-Josef Mais
  • Patent number: 8853398
    Abstract: The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate of the formula (I) and to a process for purifying the crude product of the compound of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate sulphinyldimethane (1:1), i.e. a compound of the formula (II), is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: October 7, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Franz-Josef Mais, Joachim Rehse, Winfried Joentgen, Konrad Siegel