Abstract: The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present invention also relates to the use of said compounds in the treatment of cancer and as therapeutic agents for eukaryotic parasites and respective methods of treatment.

Abstract: The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present invention also relates to the use of said compounds in the treatment of cancer and as therapeutic agents for eukaryotic parasites and respective methods of treatment.

Abstract: The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present invention also relates to the use of said compounds in the treatment of cancer and as therapeutic agents for eukaryotic parasites and respective methods of treatment.

Abstract: A chip for performing and measuring chemical reactions, interactions (bonds), and/or conformational changes, especially fast chemical reactions and processes. The chip includes a base plate, which is made of a polymer material that is transparent at least in the measuring zone, and having. fluid ducts parallel to the plane of the base plate and includes at least two reagent feeders leading into a mixer structure that has a number of inlets corresponding to the number of reagent feeders and an outlet leading into a mixing section, the outlet of the mixing section leads into a measuring section, the outlet of the measuring section is connected to a discharge section, the discharge section leads out of the base plate or into a reservoir that is arranged on the chip, and pressure conduits lead into the reagent feeders at a distance from the mixer structure.

Abstract: The present invention relates to a homogeneous assay method of quantitative measurement of kinase, phosphatase and phosphodiesterase (PDE) reactions. The method may be used both in a direct and in a competitive assay format.

Abstract: A method for determining the chemosensitivity of cells towards at least one substance by measuring the apoptosis induced by said at least one substance, wherein the apoptosis is determined from the accumulated caspase activity of a sample comprising cells and a medium by adding said at least one substance to the sample followed by incubation, and measuring the accumulated caspase activity in the sample upon disruption of the cells without previously separating off the cells.

Abstract: A method for determining the chemosensitivity of cells towards at least one substance by measuring the apoptosis induced by said at least one substance, wherein the cells are incubated essentially concurrently with at least one marker whose interaction with phosphatidylserine can be detected and with said at least one substance, and the interaction between the marker and phosphatidylserine is detected in a time-resolved manner.

Abstract: The present invention discloses a homogeneous fluorescent binding assay method using carrier particles.

Abstract: The present invention discloses a homogeneous fluorescent binding assay method using carrier particles.

Abstract: A method for the labeling of molecules through the reaction of molecules to be labeled with labels at a solid phase (matrix), characterized in that the molecules enter a reaction chamber in which a matrix loaded with a reactive component is provided, and after the coupling has taken place, the labeled molecules leave the reaction chamber through a porous means.