Patents by Inventor Franz-Josef Rubroder

Franz-Josef Rubroder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the stabilization of proteins in an aqueous solution comprising cysteine in a concentration between 150 and 220mM
    Patent number: 7514403
    Abstract: The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of heterologous proteins in microorganisms.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: April 7, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Franz-Josef Rubröder, Reinhold Keller
  • Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents
    Publication number: 20040230038
    Abstract: The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of heterologous proteins in microorganisms.
    Type: Application
    Filed: March 10, 2004
    Publication date: November 18, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Franz-Josef Rubroder, Reinhold Keller
  • Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents
    Patent number: 6734164
    Abstract: The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of heterologous proteins in microorganisms.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: May 11, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Franz-Josef Rubröder, Reinhold Keller
  • Process for obtaining insulin precursors having correctly bonded cystine bridges
    Patent number: 6727346
    Abstract: The present invention relates to an improved process for obtaining a precursor of an insulin or insulin derivative having correctly bonded cystine bridges in the presence of cysteine or cysteine hydrochloride and chaotropic auxiliary.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: April 27, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Franz-Josef Rubröder, Reinhold Keller
  • Process for obtaining insulin precursors having correctly bonded cystine bridges
    Publication number: 20020156234
    Abstract: The present invention relates to an improved process for obtaining a precursor of an insulin or insulin derivative having correctly bonded cystine bridges in the presence of cysteine or cysteine hydrochloride and chaotropic auxiliary.
    Type: Application
    Filed: September 7, 2001
    Publication date: October 24, 2002
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Franz-Josef Rubroder, Reinhold Keller
  • Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents
    Publication number: 20020058623
    Abstract: The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of heterologous proteins in microorganisms.
    Type: Application
    Filed: November 26, 2001
    Publication date: May 16, 2002
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Franz-Josef Rubroder, Reinhold Keller
  • Process for obtaining insulin precursors having correctly bonded cystine bridges
    Patent number: 6380355
    Abstract: The present invention relates to an improved process for obtaining a precursor of an insulin or insulin derivative having correctly bonded cystine bridges in the presence of cysteine or cysteine hydrochloride and chaotropic auxiliary.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: April 30, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Franz-Josef Rubröder, Reinhold Keller
  • Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents
    Patent number: 6339061
    Abstract: The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein. The process is suitable for use in the production of heterologous proteins in microorganisms.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: January 15, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Franz-Josef Rubröder, Reinhold Keller
  • Process for obtaining insulin precursors having correctly bonded cystine bridges
    Patent number: 5986048
    Abstract: The present invention relates to an improved process for obtaining a precursor of an insulin or insulin derivative having correctly bonded cystine bridges in the presence of cysteine or cysteine hydrochloride and chaotropic auxiliary.
    Type: Grant
    Filed: August 17, 1998
    Date of Patent: November 16, 1999
    Assignee: Hoechst Marion Roussel Deutschland
    Inventors: Franz-Josef Rubroder, Reinhold Keller