Patents by Inventor Franz Legros

Franz Legros has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Freeze dried liposome encapsulated amphiphilic drug compositions and a process for the preparation thereof
    Patent number: 6221385
    Abstract: A process for the preparation of freeze dried liposome encapsulated amphiphilic drug compositions, which process comprises preparing a liposomal suspension of multilamellar vesicles (MLVs) which encapsulate an amphiphilic drug compsition, adding sorbitol to the liposomal suspension and lyophilisation of the suspension.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: April 24, 2001
    Assignee: Vrije Universiteit Brussel
    Inventors: Frederic Camu, Robert Brasseur, Franz Legros, Sandra Carlino
  • Liposome encapsulated amphiphilic drug compositions
    Patent number: 6149937
    Abstract: A process for the entrapment of amphiphilic compounds as uncharged or ionic with different mole ratios of phospholipid to the amphiphilic compound. Preparations of ionic species of amphiphilic compounds in the absence of crystals can be prepared, while preparations of uncharged amphiphilic compounds can be prepared with the compound exclusively entrapped inside the liposomes, or partly entrapped inside the liposomes with extraliposomal crystals.
    Type: Grant
    Filed: November 19, 1998
    Date of Patent: November 21, 2000
    Assignee: Vrije Universiteit Brussel
    Inventors: Frederic Camu, Mokarram Alafandy, Robert Brasseur, Franz Legros, Oliver Bouffioux
  • Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes
    Patent number: 5244678
    Abstract: The present invention relates to a pharmaceutical composition containing a local anesthetic or a centrally acting analgesic, comprising a lipophilic portion, the anesthetic or analgesic being encapsulated in liposomes.
    Type: Grant
    Filed: January 22, 1991
    Date of Patent: September 14, 1993
    Assignee: Ire-Celltarg S.A.
    Inventors: Franz Legros, Jean-Marie Ruysschaert
  • Pharmaceutical composition containing a hydrophilic active compound, treated with an organic acid and encapsulated in a liposome
    Patent number: 5211955
    Abstract: A pharmaceutical composition containing an hydrophilic aminoglucoside antibiotic coupled with an organic acid. The coupled aminoglucoside antibiotic and organic acid are encapsulated in a liposome. The composition of the invention is self-regulating in that it liberates the active compound in inverse proportion to the concentration of the compound in the external medium. As a result, the composition serves as a long-acting antibiotic while avoiding the release of a toxic or ineffective dose of the antibiotic into the subject.
    Type: Grant
    Filed: April 10, 1991
    Date of Patent: May 18, 1993
    Inventors: Franz Legros, Claude-Pascal Leroy