Patents by Inventor Franziska B. Grieder

Franziska B. Grieder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inducing an immune response with a live Venezuelan Equine Encephalitis virus expressing a heterologous immunogen
    Patent number: 5643576
    Abstract: A method of protecting a subject against a disease comprises administering a recombinant Venezuelan Equine Encephalitis (VEE) virus to the subject in an effective immunogenic amount, with the VEE virus containing a heterologous DNA segment, and with the heterologous DNA segment comprising a promoter operable in the subject operatively associated with a DNA encoding an immunogenic protein or peptide effective for protecting the subject from the disease. Preferred promoters are VEE 26S subgenomic promoters, and preferred immunogens are viral immunogens. Novel attenuating mutations useful in carrying out the invention are also disclosed.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: July 1, 1997
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Robert E. Johnston, Nancy L. Davis, Jonathan F. Smith, Franziska B. Grieder
  • Attenuating mutations in Venezuelan Equine Encephalitis virus
    Patent number: 5505947
    Abstract: Novel attenuating mutations of Venezuelan Equine Encephalitis (VEE) are disclosed. Further aspects of the invention include an infectious VEE virus transcript encoded by cDNA clones, infectious VEE virus particles, and pharmaceutical formulations containing such infectious particles. Also disclosed are recombinant VEE virus containing a heterologous RNA segment.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: April 9, 1996
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Robert E. Johnston, Nancy L. Davis, Jonathan F. Smith, Franziska B. Grieder