Abstract: An apparatus for surgical fusion of a cranio-cervical junction includes a plate member, where the plate member includes a bottom portion configured to be secured to a cranium; a top portion including a plurality of perforations extending therethrough configured to promote bone growth, wherein the top portion and the bottom portion define a graft accommodation space; and first and second side portions coupled to the top and bottom portions on first and second sides of the graft accommodation space. The first side portion is configured to receive a first support rod and the second side portion is configured to receive a second support rod.

Abstract: An apparatus for surgical fusion of a cranio-cervical junction includes a plate member, where the plate member includes a bottom portion configured to be secured to a cranium; a top portion including a plurality of perforations extending therethrough configured to promote bone growth, wherein the top portion and the bottom portion define a graft accommodation space; and first and second side portions coupled to the top and bottom portions on first and second sides of the graft accommodation space. The first side portion is configured to receive a first support rod and the second side portion is configured to receive a second support rod.

Abstract: A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.

Abstract: A therapeutic method for treating a neurological disease by accessing a neuraxial deformity and abnormal neuraxial stress. The method involves calculating a neuraxial stress, determining whether the neurological disorder is attributed at least in part to the neuraxial stress; and treating the neurological disorder by normalizing the neuraxial stress.

Abstract: A therapeutic method for treating a neurological disease by evaluating and correcting an abnormal neuraxial angle that cause abnormal biomechanically induced neuraxial stress and strain.

Abstract: A vertebral attachment method and system that minimizes or eliminates the risk of severing, compressing, impinging or otherwise injuring the vertebral artery vertebral vein, spinal nerve roots and/or spinal cord. The system includes at least one plate that may be anchored to a posterior region of a vertebra using at least one clamp and fastener. The system may be specifically designed to retain a portion of the posterior region of the vertebra.

Abstract: A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use an osteointegration apparatus that includes a porous ossomeric mesh and a frame member.

Abstract: A spinal stabilization system that may be used to fix craniocervical junction. The system includes a cranial spinal attachment system that anchors one or more surgical instruments to a cranial surface using at least one cranial clamp and cranial fastener. The cranial spinal attachment system may be positioned along a perimeter of a cranial defect.

Abstract: A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.

Abstract: A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.

Abstract: A therapeutic method for treating a neurological disease by accessing a neuraxial deformity and abnormal neuraxial stress. The method involves calculating a neuraxial stress, determining whether the neurological disorder is attributed at least in part to the neuraxial stress; and treating the neurological disorder by normalizing the neuraxial stress.

Abstract: A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.

Abstract: A spinal stabilization system that may be used to fix craniocervical junction. The system includes a cranial spinal attachment system that anchors one or more surgical instruments to a cranial surface using at least one cranial clamp and cranial fastener. The cranial spinal attachment system may be positioned along a perimeter of a cranial defect.

Abstract: A therapeutic method for treating a neurological disease by evaluating and correcting an abnormal neuraxial angle that cause abnormal biomechanically induced neuraxial stress and strain.

Abstract: A shunt system for telemetrically measuring, regulating and/or adjusting cerebrospinal fluid flow rate, intercranial pressure, intraspinal pressure and/or intraventricular pressure and a method for use. The shunt system includes a shunt assembly, a first catheter and a second catheter that may be implanted using a novel introducer assembly. In addition to regulating fluid pressure and flow rate, the shunt system may also be used to deliver therapeutic compositions.

Abstract: A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use an osteointegration apparatus that includes a porous ossomeric mesh and a frame member.

Abstract: A method for treating a neurological condition such as autism spectrum disorder, bipolar disorder or other neurological condition that may be caused by biomechanical stresses imparted to the brainstem is performed by surgically correcting the clivo-axial angle of the patient and stabilizing the cranio-cervical junction after surgery. The surgery will relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, and is preferably performed by effecting a fusion of a first portion of a bone forming material based member to a human cranium, and effecting fusion of a second portion of the bone forming material based member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.

Abstract: A vertebral attachment method and system that minimizes or eliminates the risk of severing, compressing, impinging or otherwise injuring the vertebral artery vertebral vein, spinal nerve roots and/or spinal cord. The system includes at least one plate that may be anchored to a posterior region of a vertebra using at least one clamp and fastener. The system may be specifically designed to retain a portion of the posterior region of the vertebra.

Abstract: A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.

Abstract: A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.