Patents by Inventor Fraser D. Rubens

Fraser D. Rubens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fibrin D-domain multimer prostheses and methods for their production
    Patent number: 5693098
    Abstract: Methods for coating a prosthetic surface with anti-thrombogenic, or anti-coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. These multimers, preferably D-dimers, have cross-linked D-domains. The methods of the invention are useful for providing an anti-thrombogenic coating on prosthetic implants which are exposed to a patient's blood after implantation, for example vascular grafts and artificial heart valves.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: December 2, 1997
    Assignees: McMaster University, ZymoGenetics, Inc.
    Inventors: Fraser D. Rubens, Paul D. Bishop
  • Fibrin D-domain multimer coated prostheses and methods for their production
    Patent number: 5609631
    Abstract: Methods for coating a prosthetic surface with anti-thrombogenic, or anti-coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. These multimers, preferably D-dimers, have cross-linked D-domains. The methods of the invention are useful for providing an anti-thrombogenic coating on prosthetic implants which are exposed to a patient's blood after implantation, for example vascular grafts and artificial heart valves.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: March 11, 1997
    Inventors: Fraser D. Rubens, Paul D. Bishop
  • Fibrin coated polymer surfaces
    Patent number: 5324647
    Abstract: Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and prosthetic devices, and provide test systems useful in the study of thrombogenesis.
    Type: Grant
    Filed: September 14, 1993
    Date of Patent: June 28, 1994
    Assignees: McMaster University, ZymoGenetics, Inc.
    Inventors: Fraser D. Rubens, Paul D. Bishop
  • Fibrin coated polymer surfaces
    Patent number: 5272074
    Abstract: Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and prosthetic devices, and provide test systems useful in the study of thrombogenesis.
    Type: Grant
    Filed: April 23, 1992
    Date of Patent: December 21, 1993
    Assignee: McMaster University
    Inventor: Fraser D. Rubens