Patents by Inventor Fraser McIntosh

Fraser McIntosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays for Allosteric Modulators of G-Protein Coupled Receptors (GPCRs)
    Publication number: 20090305321
    Abstract: The present invention relates to G protein-coupled receptors (GPCRs) and allosteric modulators thereof. More specifically, the invention relates to allosteric modulators of GPCRs that interact at an intracellular binding site. It also relates to methods for designing or identifying small molecule allosteric modulators, including assays (such as competitive binding assays) and methods employing a homology model for the GPCR intracellular site.
    Type: Application
    Filed: March 22, 2006
    Publication date: December 10, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Caroline Grahames, Philip Mallinder, Fraser McIntosh, Nicholas Tomkinson, Tracey Wright
  • Composition for the treatment of damaged tissue
    Publication number: 20050026836
    Abstract: A pharmaceutical for use in damaged tissue, such as wound, treatment (e.g. healing) is described. The pharmaceutical comprising a composition which comprises: (a) a growth factor; and (b) an inhibitor agent; and optionally (c) a pharmaceutically acceptable carrier, diluent or excipient; wherein the inhibitor agent can inhibit the action of at least one specific adverse protein (e.g. a specific protease) that is upregulated in a damaged tissue, such as a wound, environment.
    Type: Application
    Filed: July 28, 2004
    Publication date: February 3, 2005
    Inventors: Kevin Dack, Michael Davies, Paul Fish, Jonathan Huggins, Fraser McIntosh, Nicholas Occleston