Abstract: Some implementations include a system comprising an electrical line positioned proximate to one or more subsurface formations; and a permanent downhole sensor array coupled to the electrical line, the permanent downhole sensor array including one or more downhole sensors, each downhole sensor including: a first sensing device configured to detect at least a first component of a downhole fluid.

Abstract: Alkoxy-substituted N-benzyl-2-phenylacetamide compounds and derivatives are G-protein coupled receptor (GPR) 88 modulators for use in the treatment of a disease mediated by GPR88. Indications include Tourette's Syndrome, Huntington's Disease (HD), Addiction, Parkinson's Disease (PD), Schizophrenia, and Attention Deficit Hyperactivity Disorder (ADHD), choreiform movements, speech delay, learning disabilities, depression, hyperkinetic movement disorders characterised by chorea and/or dystonia, psychosis, cognitive deficits in schizophrenia, affective disorders, bipolar disorder, Alzheimer's disease and basal ganglia disorders.

Abstract: Cycloalkylmethoxy- and cycloalkyloxy-substituted N-benzyl-2-phenylacetamide compounds and derivatives are G-protein coupled receptor (GPR) 88 modulators for use in the treatment of a disease mediated by GPR88. Indications include Tourette's Syndrome, Huntington's Disease (HD), Addiction, Parkinson's Disease (PD), Schizophrenia, and Attention Deficit Hyperactivity Disorder (ADHD), choreiform movements, speech delay, learning disabilities, depression, hyperkinetic movement disorders characterised by chorea and/or dystonia, psychosis, cognitive deficits in schizophrenia, affective disorders, bipolar disorder, Alzheimer's disease and basal ganglia disorders.

Abstract: Some implementations include a system comprising an electrical line positioned proximate to one or more subsurface formations; and a permanent downhole sensor array coupled to the electrical line, the permanent downhole sensor array including one or more downhole sensors, each downhole sensor including: a first sensing device configured to detect at least a first component of a downhole fluid.

Abstract: Provided is a flow control valve, a well system, and a method. The flow control valve, in one aspect, includes a tubular configured to be positioned downhole in a wellbore, the tubular having a central longitudinal axis, and a piston located in the tubular, the piston configured to separate injection fluid located within the tubular from a working fluid located in a sealed working fluid chamber. The flow control valve, according to this aspect, further includes a valve assembly located within the tubular and coupled with the piston, wherein the piston is configured to axially slide within the tubular to move the valve assembly between an open position that provides a fluid passageway for the injection fluid from the tubular into a subterranean formation and a closed position that closes the fluid passageway for the injection fluid from the tubular into the subterranean formation, based upon a density of the injection fluid.

Abstract: Provided is a flow control valve, a well system, and a method. The flow control valve, in one aspect, includes a tubular configured to be positioned downhole in a wellbore, the tubular having a central longitudinal axis, and a piston located in the tubular, the piston configured to separate injection fluid located within the tubular from a working fluid located in a sealed working fluid chamber. The flow control valve, according to this aspect, further includes a valve assembly located within the tubular and coupled with the piston, wherein the piston is configured to axially slide within the tubular to move the valve assembly between an open position that provides a fluid passageway for the injection fluid from the tubular into a subterranean formation and a closed position that closes the fluid passageway for the injection fluid from the tubular into the subterranean formation, based upon a density of the injection fluid.

Abstract: Provided is a downhole material test sub assembly, a well system including the same, and a method for using the same. The downhole material test sub assembly, in one aspect, includes a flange for coupling to a mandrel, and one or more retainer assemblies coupled to the flange, the one or more retainer assemblies configured to accept a test specimen for running within a wellbore on the mandrel. The downhole material test sub assembly, according to another aspect, includes a mandrel and one or more grooves or pockets located in an outer surface of the mandrel, the one or more grooves or pockets configured to accept a test specimen for running within a wellbore on the mandrel.

Abstract: Provided is a downhole material test sub assembly, a well system including the same, and a method for using the same. The downhole material test sub assembly, in one aspect, includes a flange for coupling to a mandrel, and one or more retainer assemblies coupled to the flange, the one or more retainer assemblies configured to accept a test specimen for running within a wellbore on the mandrel. The downhole material test sub assembly, according to another aspect, includes a mandrel and one or more grooves or pockets located in an outer surface of the mandrel, the one or more grooves or pockets configured to accept a test specimen for running within a wellbore on the mandrel.

Abstract: A flow control valve configured to be positioned in a tubing in a borehole formed in a subsurface formation, wherein the flow control is used to regulate a flow of an injection fluid into the subsurface formation based on a vapor-transition characteristic of a fluid contained within a chamber of the flow control valve.

Abstract: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ring A, Ring B, Ring C, R1, R2, R3, R4, R5, L, m, n, and p are as defined herein. The compounds are modulators of G-protein coupled receptor 88 (GPR88). Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in the treatment of diseases mediated by GPR88, including Tourette's Syndrome, Huntington's Disease (HD), Addiction, Parkinson's Disease (PD), Schizophrenia, Alzheimer's disease, and Attention Deficit Hyperactivity Disorder (ADHD).

Abstract: A flow control valve configured to be positioned in a tubing in a borehole formed in a subsurface formation, wherein the flow control is used to regulate a flow of an injection fluid into the subsurface formation based on a vapor-transition characteristic of a fluid contained within a chamber of the flow control valve.

Abstract: Provided is a downhole material test sub assembly, a well system including the same, and a method for using the same. The downhole material test sub assembly, in one aspect, includes a flange for coupling to a mandrel, and one or more retainer assemblies coupled to the flange, the one or more retainer assemblies configured to accept a test specimen for running within a wellbore on the mandrel. The downhole material test sub assembly, according to another aspect, includes a mandrel and one or more grooves or pockets located in an outer surface of the mandrel, the one or more grooves or pockets configured to accept a test specimen for running within a wellbore on the mandrel.

Abstract: Provided is a downhole material test sub assembly, a well system including the same, and a method for using the same. The downhole material test sub assembly, in one aspect, includes a flange for coupling to a mandrel, and one or more retainer assemblies coupled to the flange, the one or more retainer assemblies configured to accept a test specimen for running within a wellbore on the mandrel. The downhole material test sub assembly, according to another aspect, includes a mandrel and one or more grooves or pockets located in an outer surface of the mandrel, the one or more grooves or pockets configured to accept a test specimen for running within a wellbore on the mandrel.

Abstract: A flow control valve configured to be positioned in a tubing in a borehole formed in a subsurface formation, wherein the flow control is used to regulate a flow of an injection fluid into the subsurface formation based on a vapor-transition characteristic of a fluid contained within a chamber of the flow control valve.

Abstract: The invention relates to improved ANTISENSE agents for the treatment of gram-negative bacterial infections. Compounds of the invention utilise an Antibiotic-Assisted Translocation; AAT? platform to improve influx into bacterial cells through enhanced permeability, providing improved intracellular exposure of the ANTISENSE AGENT and superior treatment of the infection.