Patents by Inventor Fraser Sim

Fraser Sim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulating the production of neurons and/or oligodendrocytes from white matter progenitor cells
    Patent number: 10485807
    Abstract: The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: November 26, 2019
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Steven A. Goldman, Fraser Sim
  • MODULATING THE PRODUCTION OF NEURONS AND/OR OLIGODENDROCYTES FROM WHITE MATTER PROGENITOR CELLS
    Publication number: 20170119787
    Abstract: The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.
    Type: Application
    Filed: November 15, 2016
    Publication date: May 4, 2017
    Inventors: Steven A. GOLDMAN, Fraser SIM
  • MODULATING THE PRODUCTION OF NEURONS AND/OR OLIGODENDROCYTES FROM WHITE MATTER PROGENITOR CELLS
    Publication number: 20150216875
    Abstract: The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.
    Type: Application
    Filed: December 29, 2014
    Publication date: August 6, 2015
    Inventors: Steven A. GOLDMAN, Fraser SIM
  • Modulating the production of neurons and/or oligodendrocytes from white matter progenitor cells
    Patent number: 8945921
    Abstract: The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: February 3, 2015
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Steven A. Goldman, Fraser Sim
  • CD24 AS A BRAIN TUMOR STEM CELL MARKER AND A DIAGNOSTIC AND THERAPEUTIC TARGET IN PRIMARY NEURAL AND GLIAL TUMORS OF THE BRAIN
    Publication number: 20110002846
    Abstract: The present invention is directed to methods of treating a primary brain tumor and preventing the migratory spread of a primary brain tumor in a subject. These methods involve utilizing the CD24 surface protein selectively expressed on tumor progenitor cells as a therapeutic target as well as a means for directing oncolytic therapeutics directly to the tumor site. The present invention further relates to methods of diagnosing the presence of a brain tumor and monitoring the status of the brain tumor in a subject based on CD24 expression in tumor progenitor cells.
    Type: Application
    Filed: December 22, 2008
    Publication date: January 6, 2011
    Applicant: Univeristy of Rochester
    Inventors: Steven A. Goldman, Fraser Sim, Romane Melanie Auvergne
  • Genes differentially expressed by acutely isolated resident progenitor cells of the human white matter
    Publication number: 20050176626
    Abstract: The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.
    Type: Application
    Filed: November 10, 2004
    Publication date: August 11, 2005
    Inventors: Steven Goldman, Fraser Sim