Patents by Inventor Fred A. David
Fred A. David has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240122926Abstract: Apelin receptor modulators can improve physical performance, slow progression of age-related frailty, and can reduce age-related muscle weakness in human patients. This disclosure provides methods for treating muscle conditions using a particular class of apelin receptor modulators (e.g., agonists). The muscle condition can be an age-related muscle condition. Also provided is a method for maintaining and/or increasing muscle mass, muscle function, and/or muscle strength in an elderly subject by administration of the apelin receptor modulator. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: September 27, 2023Publication date: April 18, 2024Inventors: Kristen Patricia FORTNEY, Eric Kim MORGEN, Justin REBO, Robert HUGHES, Fred ASWAD, Peng Khun LEONG, Sashanaz H. IGDARI, Paul David RUBIN, Rusty Lee MONTGOMERY
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Publication number: 20230331824Abstract: Single-domain antibodies that bind the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) spike protein are disclosed. The single-domain antibodies include binding domains that bind epitopes of the Spike ectodomain inside and outside the receptor binding domain. The single-domain antibodies can be used for multiple purposes including in the research, diagnosis, and prophylactic or therapeutic treatment of COVID-19.Type: ApplicationFiled: August 20, 2021Publication date: October 19, 2023Applicants: The Rockefeller University, Seattle Children's Hospital d/b/a Seattle Children's Research Institute, New York UniversityInventors: Brian T. Chait, Michael P. Rout, John Aitchison, Fred David Mast, Jean Paul Olivier, David Fenyo
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Publication number: 20190252050Abstract: This invention concerns an integrated method for providing individuals with current assessments of genetic risk based on genetic tests and genomic research. While existing genetic tests can provide an estimate of genetic risk for many common diseases, genomic research is expected to provide a large number of new genetic test that will enable more definitive assessments of an individual's risk of disease. The invention provides an integrated method and systems for providing individuals with a current assessment of their genetic risk based on such advances. This method has utility in enabling individuals and healthcare professions to use genetic tests in important healthcare and lifestyle decisions.Type: ApplicationFiled: September 13, 2018Publication date: August 15, 2019Applicant: National Biomedical Research FoundationInventor: Fred David Ledley
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Patent number: 8483966Abstract: This invention describes a method and site for providing genetic testing using the Internet which enables individuals to access genetic testing as well as methods that ensure privacy in the selection of genetic tests, payment, performance of tests, delivery of results, interpretation of results, and genetic counseling. These methods will increase the utilization of genetic testing by individuals.Type: GrantFiled: August 1, 2000Date of Patent: July 9, 2013Assignee: National Biomedical Research FoundationInventor: Fred David Ledley
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Patent number: 8438042Abstract: This invention provides an instrument for obtaining consent for a genetic test that comprises three or more integrated elements including an information element for conveying information to an individual concerning a genetic test, and instruction element for use by a practitioner in instructing individuals on the genetic test and use of the instrument, a collection element for collecting an individual's medical and family history, a assessment element for assessing the individual's retention and understanding of information concerning a genetic test, a certification element for certifying the individual's consent to said tests, as well as housekeeping elements useful for recording a medical record, labeling a sample, and billing. Also provided is a method for obtaining informed consent for a genetic test using an integrated instrument. The instruments and methods disclosed have utility in obtaining informed consent for genetic tests.Type: GrantFiled: April 25, 2002Date of Patent: May 7, 2013Assignee: National Biomedical Research FoundationInventor: Fred David Ledley
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Patent number: 7838605Abstract: Embodiments of our invention relate generally to methods of monitoring and controlling polymerization reactions including reactions producing multimodal polymer products using multiple catalysts in a single reactor. Embodiments of the invention provide methods of rapidly monitoring and controlling polymerization reactions without the need to sample and test the polymer properties. The method uses reactor control data and material inventory data in a mathematical leading indicator function to control the reactor conditions, and thereby the products produced under those conditions.Type: GrantFiled: September 29, 2004Date of Patent: November 23, 2010Assignee: Univation Technologies, LLCInventors: David Jack Sandell, Marjorie E. King, Fred David Ehrman
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Patent number: 7585923Abstract: Embodiments of our invention relate generally to methods of monitoring and controlling polymerization reactions including reactions producing multimodal polymer products using multiple catalysts in a single reactor. Embodiments of the invention provide methods of rapidly monitoring and controlling polymerization reactions without the need to sample and test the polymer properties. The method uses reactor control data and material inventory data in a mathematical leading indicator function to control the reactor conditions, and thereby the products produced under those conditions.Type: GrantFiled: September 29, 2004Date of Patent: September 8, 2009Assignee: Univation Technologies, LLCInventors: David Jack Sandell, Marjorie E. King, Fred David Ehrman
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Patent number: 7101629Abstract: A film comprising a polyethylene composition, the polyethylene composition in one embodiment comprising a high molecular weight component having a weight average molecular weight of greater than 50,000 amu and a low molecular weight component having a weight average molecular weight of less than 50,000 amu; the polyethylene composition possessing a density of between 0.940 and 0.970 g/cm3, and an I21 value of less than 20 dg/min; characterized in that the polyethylene composition extrudes at an advantageously high specific throughput at an advantageously low melt temperature, and wherein the film has a gel count of less than 100.Type: GrantFiled: December 9, 2004Date of Patent: September 5, 2006Assignee: Univation Technologies, LLCInventors: Porter C. Shannon, Rakesh Kumar, Pradeep Pandurang Shirodkar, Fred David Ehrman, Mark B. Davis, Keith Wesley Trapp, Dongming Li
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Patent number: 7090927Abstract: A film comprising a polyethylene composition, the polyethylene composition in one embodiment comprising a high molecular weight component having a weight average molecular weight of greater than 50,000 amu and a low molecular weight component having a weight average molecular weight of less than 50,000 amu; the polyethylene composition possessing a density of between 0.940 and 0.970 g/cm3, and an I21 value of less than 20 dg/min; characterized in that the polyethylene composition extrudes at an advantageously high specific throughput at an advantageously low melt temperature, and wherein the film has a gel count of less than 100.Type: GrantFiled: December 9, 2004Date of Patent: August 15, 2006Assignee: Univation Technologies, LLCInventors: Porter C. Shannon, Rakesh Kumar, Pradeep Pandurang Shirodkar, Fred David Ehrman, Mark B. Davis, Keith Wesley Trapp, Dongming Li
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Patent number: 6943134Abstract: A process of producing a bimodal polyolefin composition is described, which includes in one embodiment contacting monomers with a supported bimetallic catalyst composition for a time sufficient to form a bimodal polyolefin composition that includes a high molecular weight polyolefin component and a low molecular weight polyolefin component; wherein the supported bimetallic catalyst includes a first catalyst component that is preferably non-metallocene, and a second catalyst component that includes a metallocene catalyst compound having at least one fluoride or fluorine containing leaving group, wherein the bimetallic catalyst is supported by an enhanced silica, dehydrated at a temperature of 800° C. or more in one embodiment.Type: GrantFiled: September 20, 2004Date of Patent: September 13, 2005Assignee: Univation Technologies, LLCInventors: Chi-I Kuo, G. McCullough Laughlin, Pradeep Pandurang Shirodkar, Fred David Ehrman, Porter Shannon, Robert Lynn Santana, Steven K. Ackerman, Daniel Gerard O'Neil
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Patent number: 6878454Abstract: A film comprising a polyethylene composition, the polyethylene composition in one embodiment comprising a high molecular weight component having a weight average molecular weight of greater than 50,000 amu and a low molecular weight component having a weight average molecular weight of less than 50,000 amu; the polyethylene composition possessing a density of between 0.940 and 0.970 g/cm3, and an I21 value of less than 20 dg/min; characterized in that the polyethylene composition extrudes at an advantageously high specific throughput at an advantageously low melt temperature, and wherein the film has a gel count of less than 100.Type: GrantFiled: February 18, 2004Date of Patent: April 12, 2005Assignee: Univation Technologies, LLCInventors: Porter C. Shannon, Rakesh Kumar, Pradeep Pandurang Shirodkar, Fred David Ehrman, Mark B. Davis, Keith Wesley Trapp, Dongming Li
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Patent number: 6875828Abstract: A process of producing a bimodal polyolefin composition is described, which includes in one embodiment contacting monomers with a supported bimetallic catalyst composition for a time sufficient to form a bimodal polyolefin composition that includes a high molecular weight polyolefin component and a low molecular weight polyolefin component; wherein the supported bimetallic catalyst includes a first catalyst component that is preferably non-metallocene, and a second catalyst component that includes a metallocene catalyst compound having at least one fluoride or fluorine containing leaving group, wherein the bimetallic catalyst is supported by an enhanced silica, dehydrated at a temperature of 800° C. or more in one embodiment.Type: GrantFiled: February 18, 2003Date of Patent: April 5, 2005Assignee: Univation Technologies, LLCInventors: Chi-I Kuo, G. McCullough Laughlin, Pradeep Pandurang Shirodkar, Fred David Ehrman, Porter Shannon, Robert Lynn Santana, Steven K. Ackerman, Daniel Gerard O'Neil
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Patent number: 6833416Abstract: A method of transitioning catalysts for polyolefin polymerization is provided. In one aspect, the process includes providing a polymerization reactor that includes a first catalyst system, contacting olefin monomers with the first catalyst system to form polyolefin in a first polymerization reaction and introducing a catalyst killer to the polymerization reactor in an amount sufficient to terminate the first polymerization reaction. The method further includes introducing a second catalyst system to the polymerization reactor in the presence of at least a portion of the catalyst killer, wherein the at least a portion of the catalyst killer is an amount sufficient to activate the second catalyst system and contacting olefin monomers with the second catalyst system to form polyolefin in a second polymerization reaction.Type: GrantFiled: February 27, 2004Date of Patent: December 21, 2004Assignee: Univation Technologies, LLCInventors: Michael Allen Kinnan, Fred David Ehrman, Pradeep Pandurang Shirodkar, Mark Bradley Davis, Michele Lynn Grief-Rust
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Patent number: 6833417Abstract: A process of transitioning from a first polymerization reaction conducted in the presence of a mixed catalyst system to a second polymerization reaction conducted in the presence of a chrome-based catalyst system is disclosed, the polymerization reactions being conducted in one embodiment in a polymerization zone of a gas phase fluidized bed reactor which contains a fluidized bed of polymer particles by the essentially continuous passage of monomer gases through the polymerization zone, comprising: a) discontinuing the introduction of the mixed catalyst system into the reactor; b) maintaining polymerization conditions in the reactor and permitting polymerization to continue for a period of time to allow the components of the mixed catalyst system present in the reactor to produce additional polymer particles; c) introducing a deactivating agent into the fluidized bed in an amount sufficient to deactivate the mixed catalyst system; d) establishing optimal conditions within the reactor for the chrome-basedType: GrantFiled: April 29, 2004Date of Patent: December 21, 2004Assignee: Univation Technologies, LLCInventors: Fred David Ehrman, Mark Bradley Davis, Ronald Steven Eisinger, Mark Gregory Goode, Michael Allen Kinnan
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Publication number: 20040214969Abstract: A process of transitioning from a first polymerization reaction conducted in the presence of a mixed catalyst system comprising to a second polymerization reaction conducted in the presence of a chrome-based catalyst system is disclosed, the polymerization reactions being conducted in one embodiment in a polymerization zone of a gas phase fluidized bed reactor which contains a fluidized bed of polymer particles by the essentially continuous passage of monomer gases through the polymerization zone, comprising:Type: ApplicationFiled: April 29, 2004Publication date: October 28, 2004Inventors: Fred David Ehrman, Mark Bradley Davis, Ronald Steven Eisinger, Mark Gregory Goode, Michael Allen Kinnan
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Publication number: 20040186250Abstract: A method of transitioning catalysts for polyolefin polymerization is provided. In one aspect, the process includes providing a polymerization reactor that includes a first catalyst system, contacting olefin monomers with the first catalyst system to form polyolefin in a first polymerization reaction and introducing a catalyst killer to the polymerization reactor in an amount sufficient to terminate the first polymerization reaction. The method further includes introducing a second catalyst system to the polymerization reactor in the presence of at least a portion of the catalyst killer, wherein the at least a portion of the catalyst killer is an amount sufficient to activate the second catalyst system and contacting olefin monomers with the second catalyst system to form polyolefin in a second polymerization reaction.Type: ApplicationFiled: February 27, 2004Publication date: September 23, 2004Inventors: Michael Allen Kinnan, Fred David Ehrman, Pradeep Pandurang Shirodkar, Mark Bradley Davis, Michele Lynn Grief-Rust
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Patent number: 6753390Abstract: A gas phase polymerization process for producing a polyolefin composition is described, which includes passing a gaseous stream containing hydrogen gas and one or more monomers, including ethylene monomers, through a reactor that includes a fluidized bed, under reactive conditions, in the presence of a catalyst that includes metallocene, to provide a polyolefin composition, wherein in one embodiment the fluidized bulk density is 60% or more of the settled bulk density (or, a voidage of 40% or less); and wherein the voidage is controlled by a number of factors including, in certain embodiments, (a) the reactor temperature being maintained at 100° C. or below; (b) the molar ratio of hydrogen gas to ethylene introduced into the reactor being 0.015 or below.Type: GrantFiled: February 18, 2003Date of Patent: June 22, 2004Assignee: Univation Technologies, LLCInventors: Fred David Ehrman, Michael Elroy Muhle, Pradeep Pandurang Shirodkar, Keith Wesley Trapp
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Publication number: 20040044154Abstract: A process of producing a bimodal polyolefin composition is described, which includes in one embodiment contacting monomers with a supported bimetallic catalyst composition for a time sufficient to form a bimodal polyolefin composition that includes a high molecular weight polyolefin component and a low molecular weight polyolefin component; wherein the supported bimetallic catalyst includes a first catalyst component that is preferably non-metallocene, and a second catalyst component that includes a metallocene catalyst compound having at least one fluoride or fluorine containing leaving group, wherein the bimetallic catalyst is supported by an enhanced silica, dehydrated at a temperature of 800° C. or more in one embodiment.Type: ApplicationFiled: February 18, 2003Publication date: March 4, 2004Inventors: Chi-I Kuo, G. McCullough Laughlin, Pradeep Pandurang Shirodkar, Fred David Ehrman, Porter Clarke Shannon, Robert Lynn Santana, Steven K. Ackerman, Daniel Gerard O'Neil
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Patent number: D1025020Type: GrantFiled: March 4, 2022Date of Patent: April 30, 2024Assignee: GOOGLE LLCInventors: Maj Isabelle Olsson, Luke David Mastrangelo, Dustin Lee, Gina Reimann, Fred Simon
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Patent number: D1025026Type: GrantFiled: November 15, 2023Date of Patent: April 30, 2024Assignee: GOOGLE LLCInventors: Maj Isabelle Olsson, Luke David Mastrangelo, Dustin Lee, Gina Reimann, Fred Simon