Abstract: A transdermal drug delivery device includes a plurality of adhesive laminae containing the drug to be transdermally administered which laminae are separated by alternating interlaminar layers within the device and extending in stacked configuration from a contact adhesive for adhering the device to the epidermis of a user. Modulated migration of molecules of the drug serially from and through the interlaminar layers to and through the contact adhesive results from the continous physical equilibration of the drug between the multiple alternating interlaminar layers and adhesive lamine which, when stacked, provide a relatively constant rate of dermal diffusion to the skin surface (dermis) for an extended period. Discharge of the drug other than through the contact adhesive is precluded by an impermeable backing layer. Side sealing may be necessary in some instances. The drug contained in this type of device may exist in either an equilibrated or constrained physical-chemical state.