Patents by Inventor Fred Golini

Fred Golini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease nexin-I variants
    Patent number: 5457090
    Abstract: One or more amino acid residues within the reactive site region of protease nexin-I are altered in order to create analogs or variants of protease nexin-I. These analogs have substantially different protease specificities as well as different effects on regulating the activity of proteolytic enzymes which enzymes have substantial effects on a number of different physiological functions. Formulations containing the protease nexin-I variants and methods for administering these formulations to obtain desirable therapeutic results are disclosed.
    Type: Grant
    Filed: August 3, 1992
    Date of Patent: October 10, 1995
    Assignee: Incyte Pharamaceuticals, Inc.
    Inventors: Randy W. Scott, Fred Golini, Michael McGrogan
  • Protease nexin-I variants which inhibit elastase
    Patent number: 5187089
    Abstract: One or more amino acid residues within the reactive site region of protease nexin-I are altered in order to create analogs or variants or protease nexin-I. These analogs have substantially different protease specificities as well as different effects on regulating the activity of proteolytic enzymes which enzymes have substantial effects on a number of different physiological functions. Formulations containing the protease nexin-I variants and methods for administering these formulations to obtain desirable therapeutic results are disclosed.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: February 16, 1993
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Randy W. Scott, Fred Golini, Michael McGrogan