Patents by Inventor Fred H. Gage

Fred H. Gage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200339949
    Abstract: Provided herein are, inter alia, are media compositions useful for culturing neural cells. In particular, the compositions provided herein mimic important physiological conditions in the living brain and sustain neural activity. The media compositions provided herein improve the efficiency of human neuron maturation and promote synaptic function in long-term in vitro cultures.
    Type: Application
    Filed: May 14, 2020
    Publication date: October 29, 2020
    Applicant: SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Fred H. Gage, Cedric Bardy
  • Patent number: 9696297
    Abstract: Provided herein are methods and compositions useful in treating neurological disorders.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: July 4, 2017
    Assignee: SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Maria C. N. Marchetto, Fred H. Gage, Alysson R. Muotri
  • Patent number: 9340775
    Abstract: Methods and compositions for the generation and use of footprint-free human induced pluripotent stem cells are provided.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: May 17, 2016
    Assignee: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Alysson R. Muotri, Fred H. Gage, Maria C. N. Marchetto
  • Publication number: 20160108361
    Abstract: Provided herein are, inter alia, are media compositions useful for culturing neural cells. In particular, the compositions provided herein mimic important physiological conditions in the living brain and sustain neural activity. The media compositions provided herein improve the efficiency of human neuron maturation and promote synaptic function in long-term in vitro cultures.
    Type: Application
    Filed: April 17, 2014
    Publication date: April 21, 2016
    Applicant: SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Fred H. Gage, Cedric Bardy
  • Publication number: 20140038896
    Abstract: A method of treating increased non-LTR retrotransposition in a cell. The method includes exposing a neural cell to a retrotransposition inhibitor in an amount sufficient to decrease the non-LTR retrotransposition in the neural cell or a progeny of the neural cell. In various embodiments, the non-LTR retrotransposition involves at least one L1 retrotransposon. Also provided is a method of assaying retrotransposition in neural cells. The method includes sorting synchronized neural cells of the same genetic background into single neural cells, and subjecting one or more of the sorted single neural cells to quantitative polymerase chain reaction amplification of at least one retrotransposon. In addition, a method of identifying an inhibitor of retrotransposition and a identifying a neural condition associated with non-LTR retrotransposition are provided.
    Type: Application
    Filed: February 3, 2012
    Publication date: February 6, 2014
    Applicant: Salk Institute for Biological Studies
    Inventors: Fred H. Gage, Nicole Coufal, Mike McConnell, Alysson Muotri, Maria C.N. Marchetto
  • Patent number: 8630966
    Abstract: An apparatus, article and method containing an artificial neural network that, after training, produces new trainable nodes such that input data representative of a first event and input data representative of a second event both activate a subset of the new trainable nodes. The artificial neural network can generate an output that is influenced by the input data of both events. In various embodiments, the new trainable nodes are sequentially produced and show decreasing trainability over time such that, at a particular point in time, newer produced nodes are more trainable than earlier produced nodes. The artificial neural network can be included in various embodiments of methods, apparatus and articles for use in predicting or profiling events.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: January 14, 2014
    Assignee: Salk Institute for Biological Studies
    Inventors: Fred H. Gage, James Bradley Aimone, Janet Wiles
  • Publication number: 20130315886
    Abstract: A method of treating increased non-LTR retrotransposition in a cell. The method includes exposing a neural cell to a retrotransposition inhibitor in an amount sufficient to decrease the non-LTR retrotransposition in the neural cell or a progeny of the neural cell. In various embodiments, the non-LTR retrotransposition involves at least one L1 retrotransposon. Also provided is a method of assaying retrotransposition in neural cells. The method includes sorting synchronized neural cells of the same genetic background into single neural cells, and subjecting one or more of the sorted single neural cells to quantitative polymerase chain reaction amplification of at least one retrotransposon. In addition, a method of identifying an inhibitor of retrotransposition and a identifying a neural condition associated with non-LTR retrotransposition are provided.
    Type: Application
    Filed: August 4, 2010
    Publication date: November 28, 2013
    Applicant: Salk Institute for Biological Studies
    Inventors: Fred H. Gage, Nicole Coufal, Michael J. McConnell, Alysson Muotri, Maria C.N. Marchetto
  • Publication number: 20130004985
    Abstract: Provided herein are methods and compositions useful in treating neurological disorders.
    Type: Application
    Filed: December 23, 2010
    Publication date: January 3, 2013
    Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Maria C.N. Marchetto, Fred H. Gage, Alysson R. Muotri
  • Publication number: 20120129835
    Abstract: Methods of preparing and using neural cells derived from human induced pluripotent stem cell (hiPSCs), particularly hiPSCs derived from subjects with schizophrenia are provided. The hiPSC-derived neural cells can be used to screen test compounds and to identify schizophrenia marker functions. The hiPSC-derived neural cells can be used to diagnose and/or assess the severity of schizophrenia in a subject. Further, may the hiPSC-derived neural cells from a subject be used as an in vitro system to identify the most effective candidate among existing drugs for that specific subject (i.e. personalized medicine).
    Type: Application
    Filed: November 16, 2011
    Publication date: May 24, 2012
    Applicant: SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Kristen Brennand, Fred H. Gage
  • Publication number: 20120107286
    Abstract: Methods and compositions for the generation and use of footprint-free human induced pluripotent stem cells are provided.
    Type: Application
    Filed: March 24, 2010
    Publication date: May 3, 2012
    Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
    Inventors: Alysson R. Muotri, Fred H. Gage, Maria C.N. Marchetto
  • Patent number: 8092992
    Abstract: The invention provides a method for modulating gene expression by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes, wherein the association results in altered expression of the one or more genes. The invention is further directed to method for directing the differentiation of neuronal stem cells into neurons by contacting a cellular system with a double-stranded ribonucleic acid molecule capable of associating with a regulatory machinery that controls transcription of one or more genes involved in neuronal differentiation and directing the transcription of the one or more genes. In related embodiments, the invention provides particular compositions of double-stranded ribonucleic acid molecules as well as therapeutic and screening applications of the invention.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: January 10, 2012
    Assignee: Salk Institute for Biological Studies
    Inventors: Tomoko Kuwabara, Fred H. Gage
  • Publication number: 20120003655
    Abstract: Provided herein are methods for, inter alia, identifying new therapeutic agents using human cell-based models.
    Type: Application
    Filed: December 3, 2009
    Publication date: January 5, 2012
    Applicant: The Salk Institute for Biological Studies
    Inventors: Maria C.N. Marchetto, Fred H. Gage, Christopher K. Glass, Kaoru Saijo, Beate Winner
  • Publication number: 20110172105
    Abstract: Provided are compositions, libraries, and methods for the synthesis of transcripts that can be processed to produce nucleic acid capture probes. Also provided methods for using such nucleic acid capture probes in a variety of downstream applications, including, e.g., determining the sequence of an exon-exon junction.
    Type: Application
    Filed: June 4, 2009
    Publication date: July 14, 2011
    Applicant: Salk Institute for Biological Studies
    Inventors: Fred H. Gage, Jonathan Scolnick, Gene Wei Ming Yeo
  • Publication number: 20110045996
    Abstract: An analysis technique for genetic data to detect alternative spliced exons. Exon expression of similar data is analyzed using a robust regression technique to find outliers to the main regression. False outliers are detected and removed. The remaining outliers are identified as potential alternative splicing events.
    Type: Application
    Filed: August 21, 2008
    Publication date: February 24, 2011
    Inventors: Gene Yeo, Fred H. Gage
  • Publication number: 20100235310
    Abstract: An apparatus, article and method containing an artificial neural network that, after training, produces new trainable nodes such that input data representative of a first event and input data representative of a second event both activate a subset of the new trainable nodes. The artificial neural network can generate an output that is influenced by the input data of both events. In various embodiments, the new trainable nodes are sequentially produced and show decreasing trainability over time such that, at a particular point in time, newer produced nodes are more trainable than earlier produced nodes. The artificial neural network can be included in various embodiments of methods, apparatus and articles for use in predicting or profiling events.
    Type: Application
    Filed: January 27, 2010
    Publication date: September 16, 2010
    Inventors: Fred H. Gage, James Bradley Aimone, Janet Wiles
  • Patent number: 7763588
    Abstract: The invention provides a method for improving cognitive performance in a physically active subject. The invention further provides a method of enhancing neurogenesis in a physically active subject. In one embodiment, the method encompasses administering to the subject an effective amount of one or more flavonoids. In a further embodiment, the method encompasses administering to the subject an effective amount of one or more antioxidants.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: July 27, 2010
    Assignees: The Salk Institute for Biological Studies, Mars, Incorporated
    Inventors: Henriette van Praag, Fred H. Gage, John Hammerstone, Mark Allen Kelm
  • Publication number: 20100184152
    Abstract: Disclosed herein are methods of amplifying target nucleic acid sequences (e.g., DNA or RNA), particularly from a very small amount of starting material, such as a single cell. These methods involve targeting the amplification of specific sequence(s) by use of sequence-specific primers and random primers for whole genome amplification using multiple displacement amplification. Generally, the provided methods are referred to herein as “target-oriented” whole genome amplification. Starting material for target-oriented whole genome amplification can be any sample containing DNA or RNA, however, the technique is particularly suitable for very small amounts of starting material, such as a few cells, a single cell, or a single nucleus. The methods provide amplified nucleic acid (including the target sequence of interest) that can subsequently be analyzed.
    Type: Application
    Filed: October 22, 2007
    Publication date: July 22, 2010
    Inventors: Vladislav Sandler, Fred H. Gage
  • Patent number: 7732201
    Abstract: A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: June 8, 2010
    Assignee: The Regents of the University of California
    Inventors: Fred H. Gage, Jasodhara Ray
  • Patent number: 7674455
    Abstract: Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to the cell body. Additionally, methods for expressing secreted proteins from a nerve cell body as well as methods for treating neurodegenerative disorders such as amyotrophic lateral sclerosis are described.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: March 9, 2010
    Assignee: Salk Institute for Biological Studies
    Inventors: Brian K. Kaspar, Fred H. Gage, Jeffrey D. Rothstein
  • Publication number: 20080227829
    Abstract: The invention relates to method(s) of use of the compound(s) described herein, e.g. method for stimulating neurogenesis, including in vitro neurogenesis, by contacting neuronal progenitor cells with an effective amount of the compound(s) described herein; method for treatment of a subject in need of treatment with a neurogenic compound; and/or for treatment of a disease or condition associated with damage to the hippocampus. The subject may be a human or a veterinary animal.
    Type: Application
    Filed: February 13, 2008
    Publication date: September 18, 2008
    Inventors: John F. Hammerstone, Mark A. Kelm, Fred H. Gage, Henriette van Praag