Patents by Inventor Fred I. Chasalow

Fred I. Chasalow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating insulin resistance and identifying patients at risk for the disease
    Publication number: 20020165127
    Abstract: The present invention is directed to compositions and methods for treating insulin resistance and for ameliorating pathological conditions associated with insulin resistance. Also disclosed are methods for identifying patients at risk for developing non-insulin dependent diabetes melitis or insulin resistance. Also disclosed are methods for identifying patients at risk for developing or suffering from reactive hypoglycemia and methods of treatment thereof.
    Type: Application
    Filed: February 19, 2002
    Publication date: November 7, 2002
    Applicant: SuperGen, Inc.
    Inventor: Fred I. Chasalow
  • Phosphocholinate cardenolides
    Patent number: 6177461
    Abstract: Disclosed herein are cardenolides and related compounds covalently linked to phosphocholine moieties and pharmaceutical formulations comprising such compounds. Also disclosed herein are methods for treating hypertension, premenstrual syndrome (PMS), preeclampsia and polycystic kidney disease using the compounds.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: January 23, 2001
    Assignee: Kerix, L.L.C.
    Inventor: Fred I. Chasalow
  • Phosphocholinate cardenolides
    Patent number: 6130211
    Abstract: Disclosed herein are cardenolides and related compounds covalently linked to phosphocholine moieties and pharmaceutical formulations comprising such compounds. Also disclosed herein are methods for treating hypertension, premenstrual syndrome (PMS), preeclampsia and polycystic kidney disease using the compounds.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: October 10, 2000
    Assignee: Kerix, L.L.C.
    Inventor: Fred I. Chasalow
  • Phospholipid drug derivatives
    Patent number: 6127349
    Abstract: Disclosed herein are methods for increasing the bioavailability of pharmaceutical agents by conjugation to phospholipids. Also disclosed are phospholipid-derivatized steroids, peptides, antibiotics and other biologically active agents and pharmaceutical formulations comprising these compounds.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: October 3, 2000
    Assignee: Amur Research Corporation
    Inventor: Fred I. Chasalow
  • Phosphocholine drug derivatives
    Patent number: 5888990
    Abstract: Disclosed herein are methods for increasing the bioavailability of pharmaceutical agents by conjugation to phosphocholine. Also disclosed are phosphocholine-derivatized steroids, peptides and other biologically active agents and pharmaceutical formulations comprising these compounds.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: March 30, 1999
    Assignee: Amur Research Corp.
    Inventor: Fred I. Chasalow
  • Phospholipid drug derivatives
    Patent number: 5830432
    Abstract: Disclosed herein are methods for increasing the aqueous solubility and bio-availability of bioactive agents having a free carboxyl group by conjugating the agent to one or more amino alcohol phosphocholine moieties selected from the group consisting of sphingosylphosphocholine, 2-aminoglycerol phosphocholine, serine-phosphocholine, threonine phosphocholine, tyrosine-phosphocholine, aminoethanol-phosphocholine or hydroxyproline-phosphocholine. Also disclosed herein are pharmaceutical formulations comprising the agents produced by the method.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: November 3, 1998
    Assignee: Amur Pharmacuticals, Inc.
    Inventor: Fred I. Chasalow
  • Phosphocholine drug derivatives
    Patent number: 5703063
    Abstract: Disclosed herein are methods for increasing the bioavailability of pharmaceutical agents by conjugation to phosphocholine. Also disclosed are phosphocholine-derivatized steroids, peptides and other biologically active agents and pharmaceutical formulations comprising these compounds.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: December 30, 1997
    Assignee: Amur Research Corp.
    Inventor: Fred I. Chasalow
  • Diagnostic agent and methods for identifying HIV infected individuals and monitoring their therapy
    Patent number: 5643716
    Abstract: Disclosed herein are methods and a diagnostic agent for identifying HIV-infected individuals. The diagnostic agent, termed C-8.2, whose concentration is altered within about 1-3 days of HIV infection is used in assays not dependent on HIV antigens or antibodies. C-8.2 is present in the serum of all mammals and is a phospholipid or a mixture of related phospholipids.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 1, 1997
    Assignee: Amur Research Corp.
    Inventor: Fred I. Chasalow
  • Diagnositc agent and methods for identifying HIV infected individuals and monitoring their therapy
    Patent number: 5464740
    Abstract: Disclosed herein are methods and a diagnostic agent for identifying HIV-infected individuals. The diagnostic agent, termed C-8.2, whose concentration is altered within about 1-3 days of HIV infection is used in assays not dependent on HIV antigens or antibodies. C-8.2 is present in the serum of all mammals and is a phospholipid or a mixture of related phospholipids.
    Type: Grant
    Filed: May 20, 1993
    Date of Patent: November 7, 1995
    Assignee: AMUR Research Corp.
    Inventor: Fred I. Chasalow
  • Diagnostic assay for breast cancer in human female patients
    Patent number: 5130256
    Abstract: A method for determining whether a woman with gross cystic disease will develop breast cancer is provided. The method comprises analyzing human breast cyst fluid for the presence of a unique factor which has a retention time on an Amino Carbohydrate HPLC column of between about 6.4 minutes and about 6.7 minutes. The presence of this factor is diagnostically predictive for breast cancer.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: July 14, 1992
    Assignee: Long Island Jewish Medical Center
    Inventors: Fred I. Chasalow, H. Leon Bradlow
  • Treatment of Prader-Willi syndrome
    Patent number: 5006517
    Abstract: Prader-Willi Syndrome is alleviated by administering of a 3-oxo or hydroxy substituted 5-beta-androstan-17-one to an individual having the syndrome.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: April 9, 1991
    Assignees: Progenics, Inc., Long Island Jewish Medical Center
    Inventors: Leon Bradlow, Fred I. Chasalow