Patents by Inventor Fred Kruse

Fred Kruse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant expression of proteins from secretory cell lines
    Patent number: 6194176
    Abstract: The present invention a provides methods for production of heterologous polypeptides using a variety recombinantly engineered secretory cell lines. The common feature of these cell lines is the absence of expression of at least one endogenous polypeptide. The host cell machinery normally used to produce the endogenous polypeptide is then usurped for the purpose of making the heterologous polypeptide. Also described are methods engineering cells for high level expression, methods of large scale protein production, and methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: February 27, 2001
    Assignees: Board of Regents, The University of Texas System, Betagene, Inc.
    Inventors: Christopher B. Newgard, Philippe Halban, Karl D. Normington, Samuel A. Clark, Anice E. Thigpen, Christian Quaade, Fred Kruse
  • Recombinant expression of proteins from secretory cell lines
    Patent number: 6110707
    Abstract: The present invention a provides methods for production of heterologous polypeptides, for example amylin, using recombinantly engineered cell lines. Also described are methods engineering cells for high level expression, methods of large scale heterologous protein production, methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines, and methods for isolating novel amylin receptors.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: August 29, 2000
    Assignees: Board of Regents, The University of Texas System, Betagene, Inc.
    Inventors: Christopher B. Newgard, Philippe Halban, Karl D. Normington, Samuel A. Clark, Anice E. Thigpen, Christian Quaade, Fred Kruse, Dennis McGarry
  • Recombinant expression of proteins from secretory cell lines
    Patent number: 6087129
    Abstract: The present invention a provides methods for production of heterologous polypeptides using a variety recombinantly engineered secretory cell lines. The common feature of these cell lines is the absence of expression of at least one endogenous polypeptide. The host cell machinery normally used to produce the endogenous polypeptide is then usurped for the purpose of making the heterologous polypeptide. Also described are methods engineering cells for high level expression, methods of large scale protein production, and methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines.
    Type: Grant
    Filed: January 19, 1996
    Date of Patent: July 11, 2000
    Assignees: Betagene, Inc., Board of Regents, The University of Texas System
    Inventors: Christopher B. Newgard, Karl D. Normington, Samuel A. Clark, Anice E. Thigpen, Christian Quaade, Fred Kruse