Patents by Inventor Fred Lawrence Reichert

Fred Lawrence Reichert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2?-terminator nucleotide-related methods and systems
    Patent number: 8163487
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: April 24, 2012
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas W. Myers
  • 2'-Terminator Nucleotide-Related Methods and Systems
    Publication number: 20110201002
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Application
    Filed: March 10, 2011
    Publication date: August 18, 2011
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas Myers
  • 2?-Terminator nucleotide-related methods and systems
    Patent number: 7919249
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: April 5, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas Myers
  • Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescent dyes
    Patent number: 7598032
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides such as those labeled with fluorescein family dyes are advantageous in many in vitro DNA synthesis applications. Such enzymes are particularly useful for use in chain termination nucleic acid sequencing protocols, as are native forms of such enzymes. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: October 6, 2009
    Assignee: Roche Molecular Systems
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert, Christopher Lim Sigua, Thomas W. Myers
  • 2?-terminator nucleotide-related methods and systems
    Patent number: 7572581
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: August 11, 2009
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas Myers
  • 2'-Terminator Nucleotide-Related Methods and Systems
    Publication number: 20090142810
    Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.
    Type: Application
    Filed: July 16, 2008
    Publication date: June 4, 2009
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert, Veeraiah Bodepudi, Amar Gupta, Stephen Will, Thomas W. Myers
  • Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescent dyes
    Publication number: 20030152988
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides such as those labeled with fluorescein family dyes are advantageous in many in vitro DNA synthesis applications. Such enzymes are particularly useful for use in chain termination nucleic acid sequencing protocols, as are native forms of such enzymes. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Application
    Filed: January 30, 2003
    Publication date: August 14, 2003
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert, Christopher Lim Sigua, Thomas W. Myers
  • Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
    Publication number: 20020142333
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides such as those labeled with fluorescein family dyes are advantageous in many in vitro DNA synthesis applications. Such enzymes are particularly useful for use in chain termination nucleic acid sequencing protocols, as are native forms of such enzymes. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Application
    Filed: January 17, 2002
    Publication date: October 3, 2002
    Applicant: F. Hoffmann-La Roche AG.
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert, Christopher Lim Sigua, Thomas W. Myers
  • Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
    Patent number: 6346379
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides such as those labeled with fluorescein family dyes are advantageous in many in vitro DNA synthesis applications. Such enzymes are particularly useful for use in chain termination nucleic acid sequencing protocols, as are native forms of such enzymes. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: February 12, 2002
    Assignee: F. Hoffman-La Roche AG
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert, Christopher Lim Sigua, Thomas W. Myers
  • Mutant chimeric DNA polymerase
    Patent number: 6228628
    Abstract: Mutant, chimeric thermostable DNA polymerases are provided, along with purified DNA sequences that encode the enzymes. Also provided are methods for producing and using the enzymes.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: May 8, 2001
    Assignee: Roche Molecular Systems
    Inventors: David Harrow Gelfand, Fred Lawrence Reichert
  • Thermostable DNA polymerases having reduced discrimination against ribo-NTPs
    Patent number: 5939292
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides, such as ribonucleotides, into DNA products, are advantageous in many in vitro synthesis applications. Such enzymes are particularly useful for use in nucleic acid sequencing protocols and provide novel means for DNA sequence analysis. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: August 17, 1999
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert