Patents by Inventor Fred R. Frankel

Fred R. Frankel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic compositions comprising dal/dat double mutant, auxotrophic attenuated strains of Listeria and their methods of use
    Publication number: 20100189739
    Abstract: The invention includes auxotrophic attenuated mutants of Listeria and methods of their use as vaccines.
    Type: Application
    Filed: July 10, 2008
    Publication date: July 29, 2010
    Inventors: Fred R. Frankel, Daniel A. Portnoy
  • Methods of inducing immune responses through the administration of auxtrophic attenuated dal/dat double mutant Listeria strains
    Patent number: 7488487
    Abstract: The present invention includes a method of eliciting a T-cell immune response to an antigen in mammal. The method of eliciting a T-cell immune response includes administering mammal an auxotrophic attenuated strain of listeria which expresses the antigen. The auxotrophic attenuated strain of listeria includes a mutation in at least one gene whose protein product is essential for growth of bacteria.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: February 10, 2009
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Fred R. Frankel, Daniel A. Portnoy
  • Isolated nucleic acids comprising Listeria dal and dat genes
    Patent number: 6635749
    Abstract: The invention includes auxotrophic attenuated mutants of Listeria and methods of their use as vaccines.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: October 21, 2003
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Fred R. Frankel
  • Isolated nucleic acids comprising Listeria dal and dat genes
    Patent number: 6504020
    Abstract: The invention includes auxotrophic attenuated mutants of Listeria and methods of their use as vaccines.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: January 7, 2003
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Fred R. Frankel, Daniel A. Portnoy
  • Isolated nucleic acids comprising Listeria dal and dat genes
    Publication number: 20020136737
    Abstract: The invention includes auxotrophic attenuated mutants of Listeria and methods of their use as vaccines.
    Type: Application
    Filed: May 1, 2002
    Publication date: September 26, 2002
    Applicant: The Trustees of the University of Pennsylvania
    Inventor: Fred R. Frankel
  • Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use
    Patent number: 6099848
    Abstract: Listeria monocytogenes is an intracellular bacterial pathogen that elicits a strong cellular immune response following infection and therefore has potential use as a vaccine vector. However, while infections by L. monocytogenes are fairly rare and can readily be controlled by a number of antibiotics, the organism can nevertheless cause meningitis and death, particularly in immunocompromised or pregnant patients. We therefore have endeavored to isolate a highly attenuated strain of this organism for use as a vaccine vector. D-Alanine is required for the synthesis of the mucopeptide component of the cell walls of virtually all bacteria and is found almost exclusively in the microbial world. We have found in L. monocytogenes two genes that control the synthesis of this compound, an alanine racemase gene (dal) and a D-amino acid aminotransferase gene (dat).
    Type: Grant
    Filed: November 18, 1997
    Date of Patent: August 8, 2000
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Fred R. Frankel, Daniel A. Portnoy