Abstract: Provided among other things is a method of treating a diseased tissue that is a cancer tissue, virally infected tissue, or a tissue infected with an obligate intracellular parasite, in a large animal comprising: (a) administering a therapeutic agent effective for treating the disease to the animal; and (2) using over a period of time one or more phased arrays of antennas to direct pulses of radio frequency or microwave radiation in permeability-enhancing amount to the affected tissue, wherein the pulsed radiation is effective to promote the activity of the therapeutic agent against cells of the cancerous tissue or against the activity of the pathogen.

Abstract: Provided among other things is a wearable microwave radiometer. For example, a wearable microwave radiometer apparatus for measuring relative temperature differences comprising: (a) a circumambient garment configured to fit snugly; (b) control flat, flexible radiometer antenna(s) fitted to, or configured to fit to, the garment; (c) active flat, flexible radiometer antenna(s) fitted to, or configured to fit to, the garment, which active antenna(s) are configured in the apparatus to be positioned in a spaced-apart manner relative to the control antenna(s); and (d) a radiometer configured to monitor microwave signal from the control and active antennas and fitted to, or configured to fit to, the garment, wherein the antennas are operatively connected to, or configured to connect to, the radiometer.

Abstract: Provided among other things is a thermal noise imaging device with (a) thermal noise source; (b) amplifier of thermal noise; (c) antennas adapted to transmit the amplified noise to a perfused body and receive perfused body noise; (d) reference circuit adapted to receive the amplified thermal noise and produce a reference signal; (e) perfused body docking interface adapted to interface with one or more surfaces of the perfused body and (i) support a reflection set of one or more antennas in close proximity with a surface of the perfused body or (ii) support separate transmission sets of one or more antennas on opposing surfaces of the perfused body; and (f) analytical module for the perfused body noise and the reference signal and determining a reflected power from the reflection set or a transmitted power from the transmission sets.

Abstract: A microwave handheld radiometer for measuring subsurface tissue temperature of a subject includes a microwave antenna disposed relative to a handheld radiometer housing and adapted to electromagnetically couple to a skin surface of a subject, a circulator having a first circulator input and a second circulator input, wherein the first circulator input is electrically coupled to said antenna via a microwave feedline. A switch is electrically disposed between the antenna and an microwave feedline, said switch having a calibrate state and a measure state. A noise source, electrically coupled to the circulator, is being configured to provide a first source of thermal noise at a first temperature and a second source of thermal noise at a second temperature, wherein the noise source is switched between the first source and second source upon external command wherein a detector provides an output wherein surface temperature effects are corrected for the sub-surface measurement.

Abstract: Provided among other things is a thermal noise imaging device comprising: (a) a source of thermal noise; (b) an amplifier for amplifying the thermal noise; (c) one or more antennas adapted to transmit the amplified thermal noise to a perfused body and receive perfused body noise, which is the amplified thermal noise after reflection from or transmission through the perfused body; (d) a reference circuit adapted to receive the amplified thermal noise and produce a reference signal; (e) a perfused body docking interface adapted to interface with one or more surfaces of the perfused body and (i) support a reflection set of one or more antennas in close proximity with a surface of the perfused body or (ii) support separate transmission sets of one or more antennas on opposing surfaces of the perfused body; and (f) an analytical module for receiving the perfused body noise and the reference signal and determining one or more of a reflected power from the reflection set and a transmitted power from the transmission

Abstract: A microwave handheld radiometer for measuring subsurface tissue temperature of a subject includes a microwave antenna disposed relative to a handheld radiometer housing and adapted to electromagnetically couple to a skin surface of a subject, a circulator having a first circulator input and a second circulator input, wherein the first circulator input is electrically coupled to said antenna via a microwave feedline. A switch is electrically disposed between the antenna and an microwave feedline, said switch having a calibrate state and a measure state. A noise source, electrically coupled to the circulator, is being configured to provide a first source of thermal noise at a first temperature and a second source of thermal noise at a second temperature, wherein the noise source is switched between the first source and second source upon external command wherein a detector provides an output wherein surface temperature effects are corrected for in the sub-surface measurement.

Abstract: A minimally-invasive fluid-cooled insertion sleeve assembly, with an attached balloon and distally-located penetrating tip, into which sleeve any of a group comprising a rigid rod, a microwave-radiator assembly and an ultrasonic-imaging transducer assembly may be inserted, constitutes a probe of the system. The sleeve assembly comprises spaced inner and outer plastic tubes with two fluid channels situated within the coaxial lumen between the inner and outer tubes. The fluid coolant input flows through the fluid channels into the balloon, thereby inflating the balloon, and then exits through that coaxial lumen. An alternative embodiment has no balloon. The method employs the probe for piercing sub-cutaneous tissue and then ablating deep-seated tumor tissue with microwave-radiation generated heat.

Abstract: A minimally-invasive fluid-cooled insertion sleeve assembly, with an attached balloon and distally-located penetrating tip, into which sleeve any of a group comprising a rigid rod, a microwave-radiator assembly and an ultrasonic-imaging transducer assembly may be inserted, constitutes a probe of the system. The sleeve assembly comprises spaced inner and outer plastic tubes with two fluid channels situated within the coaxial lumen between the inner and outer tubes. The fluid coolant input flows through the fluid channels into the balloon, thereby inflating the balloon, and then exits through that coaxial lumen. An alternative embodiment has no balloon. The method employs the probe for piercing sub-cutaneous tissue and then ablating deep-seated tumor tissue with microwave-radiation generated heat.

Abstract: 2N?1 four-terminal phase-reversing switches are arranged in one or more columns of cascaded switches, wherein a frequency having a given relative phase ? is applied as an input of the top switch in a cascade. A particular configuration of 2N?1 different reference-values, determined by a preselected N-Bit binary code, is applied to the respective 2N?1 switches so that (1) whenever the amplitude value of an applied analog signal reaches a value equal to the reference value applied to any switch, that switch will switch to reverse the phase at its output from the phase at its input, and (2) cause the switching of the phase at the output at each switch ordinally situated in a column below that switch. The respective output phases from a certain subset of N switches of the 2N?1 switches define the binary values of the preselected N-Bit binary code output from the A/D converter.

Abstract: In a first embodiment, the antenna cooperatively situated with respect to an external surface of the balloon of a balloon catheter has a spiral configuration, which renders this external antenna highly directional. This first embodiment of balloon catheter is shown inserted in the urethra of a patient in a system for irradiating his prostatic tumor and measuring the tumor's temperature with a radiometer. In a second embodiment, the antenna cooperatively situated with respect to an external surface of the balloon of a balloon catheter has a helical configuration, which renders this external antenna omnidirectional.

Abstract: Each of various modifications of an integrated-structure inflatable balloon catheter design includes a longitudinal structure having a sharply-pointed insertion needle at a distal end of the longitudinal structure and an inflatable balloon situated intermediate a proximate end and the distal end of the longitudinal structure which is attached to said longitudinal structure. With the inflatable balloon in a deflated state, the insertion needle may be used to puncture the patient's skin and underlying sub-cutaneous tissue and place the deflated balloon in proximity to the diseased sub-cutaneous tissue, The balloon is then inflated to press against and thereby spatially deform the diseased sub-cutaneous tissue, after which the deformed diseased sub-cutaneous tissue may be therapeutically heated. This heating may be sufficient to cause the creation of a permanent cavity in the deformed diseased sub-cutaneous tissue which persists after the catheter is withdrawn.

Abstract: Each of various modifications of an integrated-structure inflatable balloon catheter design includes a longitudinal structure having a sharply-pointed insertion needle at a distal end of the longitudinal structure and an inflatable balloon situated intermediate a proximate end and the distal end of the longitudinal structure which is attached to said longitudinal structure. With the inflatable balloon in a deflated state, the insertion needle may be used to puncture the patient's skin and underlying sub-cutaneous tissue and place the deflated balloon in proximity to the diseased sub-cutaneous tissue, The balloon is then inflated to press against and thereby spatially deform the diseased sub-cutaneous tissue, after which the deformed diseased sub-cutaneous tissue may be therapeutically heated. This heating may be sufficient to cause the creation of a permanent cavity in the deformed diseased sub-cutaneous tissue which persists after the catheter is withdrawn.

Abstract: Disclosed are a plurality of different circuits employing a field effect transistor (FET), that preferably is a pseudomorphic high-electron-mobility transistor (PHEMT) that may be fabricated on a large-size monolithic chip, wherein the PHEMT is operated as a variable resistance in response to a first operating signal voltage applied to its gate and a second operating signal voltage having at least a first of two opposite polarities applied to its drain-source path, at least one of first and second operating signal voltages includes a multigigahertz frequency signal component having a certain phase; and the respective amplitudes of the first and second operating signal voltages are sufficiently low that the maximum power dissipation by the circuit is in the order of microwatts or less.

Abstract: An N-bit analog to biphase-encoded analog-to digital converter, which comprises (1) a biphase amplitude modulator responsive to an analog signal and a microwave pump carrier frequency f.sub.c for deriving a biphase-encoded carrier signal having a phase value determined by the current polarity of the analog signal and a peak amplitude determined by the current magnitude of the analog signal, and (2) an ordinally-arranged group of comparators. The modulator and the comparators, in order, derive fixed-amplitude, biphase-encoded output signals, each having a phase value indicative of a separate one of the most significant bit (MSB) to the Nth MSB in response to a biphase-encoded, modulated-carrier signal and the pump carrier frequency f.sub.c applied as inputs to each of the ordinally-arranged comparators.

Abstract: Disclosed are three embodiments of a method for determining the formation of a "biological stent" for permanently maintaining the widened bore portion of the urethra of a male patient undergoing treatment for a disease of the prostate. In this treatment, the bore portion is first temporarily widened by squeezing pressure on urethral tissue thereof applied by an inflated balloon of a microwave balloon catheter inserted in the urethera and then microwave energy sufficient to form the "biological stent" is applied to the urethral tissue. The first embodiment involves noting an observable drop in the measured value of the inflation pressure inflating the balloon when the urethral tissue has been sufficiently heated to effect a noticeable drop in the elasticity of the irradiated urethral tissue.

Abstract: Disclosed are four improvements in temperature-measuring radiometric equipment. The first improvement is directed to increasing the sensitivity of a radiometer by employing microwave noise power derived from a reference noise source in an amount that corresponds to a temperature higher than that of the specimen, and applying the reference-noise-source-derived microwave noise power as an input to the radiometer for a shorter time than is microwave noise power derived from a specimen. The second improvement is directed to reducing emissivity error by employing open-loop means comprising a microwave circulator for applying microwave noise power generated by at least one resistor thermostatically heated to a temperature in the neighborhood of the temperature of a patient's body tissue back to the body tissue.

Abstract: Disclosed are four improvements in temperature-measuring radiometric equipment. The first improvement is directed to increasing the sensitivity of a radiometer by employing microwave noise power derived from a reference noise source in an amount that corresponds to a temperature higher than that of the specimen, and applying the reference-noise-source-derived microwave noise power as an input to the radiometer for a shorter time than is microwave noise power derived from a specimen. The second improvement is directed to reducing emissivity error by employing open-loop means comprising a microwave circulator for applying microwave noise power generated by at least one resistor thermostatically heated to a temperature in the neighborhood of the temperature of a patient's body tissue back to the body tissue.

Abstract: Any one of several improved devices capable of implementing microwave phase logic (MPL) operating at gigabits per second rates comprises either at least one of means performing the function of a multigate microwave-monolithic-integrated-circuit (MMIC) field-effect transistor (FET), or a pair of doubly-balanced mixers, in which each of the mixers includes an RF port, a local-oscillator (LO) port and an IF port, and the IF port of a first of the doubly-balanced mixers is directly connected to the IF port of a second of the doubly-balanced mixers.

Abstract: Any one of several improved devices capable of implementing microwave phase logic (MPL) operating at gigabits per second rates comprises either at least one of means performing the function of a multigate microwave-monolithic-integrated-circuit (MMIC) field-effect transistor (FET), or a pair of doubly-balanced mixers, in which each of the mixers includes an RF port, a local-oscillator (LO) port and an IF port, and the IF port of a first of the doubly-balanced mixers is directly connected to the IF port of a second of the doubly-balanced mixers.

Abstract: Pulse shocks of high-frequency wave energy (e.g. RF, microwave, high-energy infra-red or laser electromagnetic wave energy or ultrasonic acoustic wave energy), rather than DC electric pulses, are employed to non-invasively produce force fields of an intensity sufficient to create transient pores in the plasma membranes of targeted cells, such as tumor cells or other diseased cells, through which either locally or systemically applied drug or chemotherapeutic agents can easily enter and be taken up by the targeted cells, even for (1) the cells of a deep-seated tumor, (2) non-localized metastasized tumor cells within a patient's body, or (3) cells (e.g., blood cells) temporarily removed to outside of a patient's body.