Abstract: Transplantation of total or partial organs or tissues from one person to another creates severe immunologic problems and does not obtain a genetic rejuvenation, for example, of half the biological age of the donor's selected tissue. The invention permits, without a return to an embryonic stage, to develop an autologous and genetic rejuvenated (AGR) tissue that can be grafted without graft rejection in the donor's body. In order to reconstitute an organ, every tissue should be treated separately and re-assembled afterwards in a cellular culture. Thus, it becomes possible to repair damaged tissues, such as: retina, myocardium, lung, kidney, hepatic, pancreas, osteoporosis, etc. using their own cells that receive a genetic rejuvenation and that remain adult and immediately functional after their implantation.